Completed Pilot Projects
2023-2024
| Recipient | Project Title |
|---|---|
| Esplugues, Enric, PhD (Comparative Medicine) | FABP5 AS A NOVEL THERAPEUTIC TARGET IN OBESITY-DRIVEN HCC |
| Jane-Wit, Daniel, MD, PhD (Cardiovascular Medicine) | Role of Cholangiocyte Derived Wnts During Cholestatic Injury |
| Mezzacappa, Catherine, MD, MPH (Digestive Diseases) | Changes in DNA methylation as markers of fatty liver disease progression |
2022-2023
| Recipient | Project Title |
|---|---|
| Bini, Jason, PhD (Radiology & Biomedical Imaging) | Positron Emission Tomography imaging of 11ß-hydroxysteroid dehydrogenase type 1 in NAFLD |
| Gupta, Vikas, MD, PhD (Digestive Diseases) | Role of Cholangiocyte Derived Wnts During Cholestatic Injury |
| Huh, Won Jae, MD, PhD (Pathology) | Sex-Hormone-Induced Differential Expression of EGF Receptor (EGFR) in Hepatocytes and Its Implication for Hepatic Steatosis |
| Yang, Xiaoyong, PhD (Comparative Medicine) | Characterizing novel paracrine factors in chronic liver disease |
2021-2022
| Recipient | Project Title |
|---|---|
| Assis, David, MD (Digestive Diseases) | A pilot study of a novel bacteriophage approach to target pathogenic gut-derived bacteria in patients with Primary Sclerosing Cholangitis |
| Mak, Michael, PhD (Biomedical Imaging) | Mechanobiology-Driven Heterogeneity and Therapeutic Resistance in Liver Cancer |
| McConnell, Matthew, MD (Digestive Diseases) | The Role of Platelets in the Pathogenesis of Alcohol-Related Hepatitis |
| Vilarinho, Silvia, MD (Digestive Diseases) | mRNA-based therapeutics for liver disease: a pilot study |
2019-2020
| Recipient | Project Title |
|---|---|
| Cai, Shi-Ying, PhD (Digestive Diseases) | Role of Ca2+/NFAT signaling pathway in cholestatic liver injury |
| Onofrey, John, PhD (Radiology & Biomedical Imaging) | Automated Hepatic Lesion Detection and LI-RADS Prediction using Deep Learning for Clinical Decision Support |
| Weerachayaphorn, Jittima PhD (Digestive Diseases) | Role of inositol 1,4,5-trisphosphate receptors in alcoholic hepatitis |
2018-2019
| Recipient | Project Title |
|---|---|
| Amenduni, Mariangela, PhD (Digestive Diseases) | Use of hiPSCs to study the function of CFTR mutations in cholangiocyte innate immunity |
| Boddupalli, Venkata, PhD (Digestive Diseases) | Delineating the role tissue resident T cells in mediating immunopathology of PSC-IBD |
| Ouyang, Xinshou, PhD (Digestive Diseases) | RNA methylation landscaping of gene regulation in macrophage-mediated inflammation in NASH |
| Tietjen, Gregory, PhD (Surgery: Transplant) | Personalized diagnostic profiling of donor livers during ex vivo perfusion |
| Wang, Steven (Siyuan), PhD (Genetics and Cell Biology) | Imaging-based 3D genomics and transcriptomics in aging liver |
2017-2018
| Recipient | Project Title |
|---|---|
| Bhat, Neha, PhD (Cardiovascular Research Center) | Characterizing the pathophysiology of metabolic syndrome upon genetic manipulation of Dyrk1b in the liver |
| Iwakiri, Yasuko, PhD (Digestive Diseases) | Lymphangiogenesis in the liver |
| Joshi, Nikhil, PhD (Immunobiology) | Understanding mechanisms of hepatocyte-induced T cell immunologic tolerance |
| Kulkarni, Supriya, PhD (Digestive Diseases) | Identification and characterization of OSTa/ß inhibitors for drug therapy in cholestasis |
| Soroka, Carol, PhD (Digestive Diseases) | Isolation of Organoids from Bile of Patients with Primary Sclerosing Cholangitis Provides a Unique Opportunity to Study Extrahepatic Biliary Cells Throughout the Progression of the Disease |
2016-2017
| Recipient | Project Title |
|---|---|
| Soroka, Carol, PhD (Digestive Diseases) | Use of Human Organoids in the Study of Liver Disease: A Model for Maintaining PSC Patient Progenitor Cells in Long-term Culture with the Potential Ability to Screen for the Efficacy of Drug Therapies |
| Mani, Arya, MD (Cardiovascular Genetics) | Investigation of liver disease in mice with impaired TCF7L2 function |
| Arterbery, Adam, PhD (Pediatrics) | The role of Inflammasome activity and the induction of the Unfolded Protein Response in the immune pathogenesis of T cells in de novo autoimmune hepatitis (DAIH) following liver transplantation” |
| Peters, Dana, PhD (Radiology and Biomedical Imaging) | Magnetic Resonance biomarkers of Acidosis in Liver Tumor Microenvironment” |
| Fiorotto, Romina, PhD (Digestive Diseases) | CFTR-defective biliary cells from human induced pluripotent-stem cells (iPSC) as a model to study the role of innate immunity in cystic fibrosis liver disease |
2015-2016
| Recipient | Project Title |
|---|---|
| Chen, Ying, PhD (Public Health) | Redox-based regulatory role of glutathione in the pathogenesis of fatty liver disease |
| Vilarinho, Silvia, MD (Digestive Diseases) | Genomic Architecture of Biliary Atresia |
| Fiorotto, Romina, PhD (Digestive Diseases) | CFTR-defective biliary cells from human induced pluripotent-stem cells (iPSC) as a model to study the role of innate immunity in cystic fibrosis liver disease |
| Ben Mamoun, Choukri, PhD (Infectious Diseases) | Elucidating the role of the solute transporter OSTa/SCL51A In malaria infection |
2014-2015
| Recipient | Project Title |
|---|---|
| Koff, Jonathan, MD (Pulmonary, Critical Care, and Sleep Medicine) | Hepatitis C virus activates EGFR to suppress antiviral immunity |
| Lomakin, Ivan, PhD (Molecular Biophysics and Biochemistry) | The structural characterization of the HCV IRES with the ribosome |
| Ruan, Hai-Bin, PhD (Biology and Physiology) | CaMKII signaling regulates liver autophagy through Ulk1 O-G1cNAcylation |
| Kibbey, Richard, MD, PhD (Endocrionology, Cellular and Molecular Physiology) | Direct measurement of hepatic PEPCK-M-Dependent Transmitochondrial Fluxes |
| Finberg, Karin, MD (Pathology) | Effect of Vitamin D on Hepatic Regulation of Systemic Iron Balance |
2013-2014
| Recipient | Project Title |
|---|---|
| Ouyang, Xinshou, PhD (Digestive Diseases) | Downregulation of HIF-1a to limit inflammasome mediated acute liver injury |
| Robek, Michael, PhD (Pathology) | A new humanized mouse model of chronic hepatitis B |
| Lee, Hochang, MD (Psychiatry) | Flumazenil treatment of HE and Changes in cortical GABA levels |
| Ekong, Udeme, MD, PhD (Pediatrics) | The role of pathogenic Th17 cells in de novo autoimmune hepatitis |
Publication Acknowledgment
To cite the Liver Center in your publications please use the following statement:
”This project was supported in part by the Yale Liver Center award NIH P30 DK034989 ________ core.”
(insert name of core(s) that you used-Morphology, Cellular Molecular, Clinical-Translational)