1982
Effect of Chlorpromazine on Hepatic Clearance and Excretion of Bile Acids by the Isolated Perfused Rat Liver 1
Tavoloni N, Reed J, Boyer J. Effect of Chlorpromazine on Hepatic Clearance and Excretion of Bile Acids by the Isolated Perfused Rat Liver 1. Experimental Biology And Medicine 1982, 170: 486-492. PMID: 7122478, DOI: 10.3181/00379727-170-41463.Peer-Reviewed Original ResearchConceptsBile acid excretionAcid excretionEffect of chlorpromazineBile acidsRat liverRat liver 1Glutamic oxalacetic transaminase activityHepatic perfusionHepatic functionTransaminase releasePerfusate concentrationPerfusate flowConstant infusionDrug AdministrationBile acid extractionControl liversHepatic clearanceGlutamic pyruvicTransaminase activityExcretionSodium taurocholateLiver 1Eventual excretionLiverChlorpromazine
1979
Effect of chlorpromazine on hepatic perfusion and bile secretory function in the isolated perfused rat liver.
Tavoloni N, Reed J, Hruban Z, Boyer J. Effect of chlorpromazine on hepatic perfusion and bile secretory function in the isolated perfused rat liver. Translational Research 1979, 94: 726-41. PMID: 227976.Peer-Reviewed Original ResearchConceptsHepatic perfusionPerfusate flowBile secretionBile acid-independent bile secretionSecretory functionBile acid excretionBile secretory functionRat liverEffect of chlorpromazineLiver 20 minLobar distributionHepatic lobeAcid excretionBaseline valuesPerfusate concentrationConstant infusionHepatic ultrastructureBile acidsControl valuesCPZSodium taurocholateLiverPerfusionGM-1Liver plasma membranes
1977
Effects of chronic choleretic infusions of bile acids on the membrane of the bile canaliculus. A biochemical and morphologic study.
Nemchausky B, Layden T, Boyer J. Effects of chronic choleretic infusions of bile acids on the membrane of the bile canaliculus. A biochemical and morphologic study. Laboratory Investigation 1977, 36: 259-67. PMID: 138767.Peer-Reviewed Original Research
1975
Scanning Electron Microscopy of the Rat Liver Studies of the effect of taurolithocholate and other models of cholestasis
Layden T, Schwarz J, Boyer J. Scanning Electron Microscopy of the Rat Liver Studies of the effect of taurolithocholate and other models of cholestasis. Gastroenterology 1975, 69: 724-738. PMID: 1158090, DOI: 10.1016/s0016-5085(19)32475-8.Peer-Reviewed Original ResearchConceptsModel of cholestasisBile duct ligationEstradiol treatmentDuct ligationEffect of cholestasisEffect of taurolithocholateTLC-induced cholestasisDirect toxic effectBile canaliculiLithocholate sulfateRat liver studiesCanalicular membraneLoss of microvilliNormal findingsFinger fracturesPortal veinDistinctive abnormalitiesSimultaneous infusionCholestasisSodium taurolithocholateSevere abnormalitiesSodium taurocholateInfusionTaurolithocholateLiver studies
1970
Canalicular Bile flow and Bile Secretory Pressure Evidence for a non-bile salt dependent fraction in the isolated perfused rat liver
Boyer J, Klatskin G. Canalicular Bile flow and Bile Secretory Pressure Evidence for a non-bile salt dependent fraction in the isolated perfused rat liver. Gastroenterology 1970, 59: 853-859. PMID: 5486271, DOI: 10.1016/s0016-5085(19)33645-5.Peer-Reviewed Original ResearchThe effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow
Boyer J, Scheig R, Klatskin G. The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow. Journal Of Clinical Investigation 1970, 49: 206-215. PMID: 5411780, PMCID: PMC322462, DOI: 10.1172/jci106229.Peer-Reviewed Original ResearchConceptsBile salt excretionBSP TmBile flowBile productionBiliary concentrationHepatic metabolismBile saltsBiliary bile salt excretionSalt excretionSulfobromophthalein sodiumSodium taurocholateMug/minSodium taurocholate infusionBile salt infusionBSP transportCholeretic propertiesSaline infusionTaurocholate infusionIndependent factorsConstant infusionHepatic uptakeMumoles/hrInfusionMul/minPeak levels