2013
Biosynthesis and trafficking of the bile salt export pump, BSEP: Therapeutic implications of BSEP mutations
Soroka CJ, Boyer JL. Biosynthesis and trafficking of the bile salt export pump, BSEP: Therapeutic implications of BSEP mutations. Molecular Aspects Of Medicine 2013, 37: 3-14. PMID: 23685087, PMCID: PMC3784619, DOI: 10.1016/j.mam.2013.05.001.Peer-Reviewed Original ResearchConceptsBenign recurrent intrahepatic cholestasis type 2Progressive familial intrahepatic cholestasis type 2Cell biological aspectsBile salt export pumpTranslational regulationCell biologyMembrane transportersPrimary transporterBile salt-dependent bile flowType 2Bile acidsRate-limiting stepExport pumpDrug-induced cholestasisBiological aspectsBiosynthesisTraffickingTransportersBSEP mutationsMutationsCholestatic diseaseIntrahepatic cholestasisBile flowBiliary systemEnterohepatic circulation
1997
Enterohepatic circulation of scymnol sulfate in an elasmobranch, the little skate (Raja erinacea)
Fricker G, Wössner R, Drewe J, Fricker R, Boyer J. Enterohepatic circulation of scymnol sulfate in an elasmobranch, the little skate (Raja erinacea). American Journal Of Physiology 1997, 273: g1023-g1030. PMID: 9374698, DOI: 10.1152/ajpgi.1997.273.5.g1023.Peer-Reviewed Original ResearchConceptsEnterohepatic circulationScymnol sulfateBile alcohol sulfatesBile flowBiliary secretionCholeretic effectMajor bile saltsHepatic uptakeHepatic eliminationIntestinal epitheliumBileLiverSkate liverHepatic transportSpecific transport mechanismsBile alcoholsMajor metaboliteFirst direct demonstrationBile saltsCholyltaurinePerfusateLittle skatePolar metabolitesCompetitive mannerDirect demonstration
1978
Stimulation of thymidine incorporation in mouse liver and biliary tract epithelium by lithocholate and deoxycholate
Bagheri S, Bolt M, Boyer J, Palmer R. Stimulation of thymidine incorporation in mouse liver and biliary tract epithelium by lithocholate and deoxycholate. Gastroenterology 1978, 74: 188-192. PMID: 620891, DOI: 10.1016/0016-5085(78)90793-x.Peer-Reviewed Original ResearchConceptsCertain bile acidsBiliary tractBile acidsBiliary tract epitheliumSingle oral dosesBile duct hyperplasiaBile acid poolBile saltsDuctular cell hyperplasiaPeliosis hepatisOral dosesHepatocellular necrosisBile ductCell hyperplasiaDuct hyperplasiaEnterohepatic circulationHepatic nodulesProliferative activityThymidine incorporationLiverEarly effectsLithocholateMouse liverDosesCell kinetics
1974
Variation in hepatic bile composition following cholecystectomy in patients with previous gallstones.
Boyer J, Bloomer J, Maddrey W, Tilson D. Variation in hepatic bile composition following cholecystectomy in patients with previous gallstones. The Yale Journal Of Biology And Medicine 1974, 47: 211-7. PMID: 4456833, PMCID: PMC2595121.Peer-Reviewed Original ResearchConceptsHepatic bileBile compositionEnterohepatic circulationBile acidsBile acid poolLithogenicity of bileHepatic bile compositionBile specimensDay study periodT-tubeCholesterol gallstonesPatientsExcretion rateCholecystectomyBileStudy periodGallstonesAcid poolAdmirandGallbladderLithogenicityCirculation