2005
The ryanodine receptor mediates early zymogen activation in pancreatitis
Husain SZ, Prasad P, Grant WM, Kolodecik TR, Nathanson MH, Gorelick FS. The ryanodine receptor mediates early zymogen activation in pancreatitis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 14386-14391. PMID: 16186498, PMCID: PMC1242288, DOI: 10.1073/pnas.0503215102.Peer-Reviewed Original Research
2004
Acute pancreatitis
Nagar AB, Gorelick FS. Acute pancreatitis. Current Opinion In Gastroenterology 2004, 20: 439-443. PMID: 15689676, DOI: 10.1097/00001574-200409000-00004.Peer-Reviewed Original ResearchAcute pancreatitisExperimental acute pancreatitisNeurokinin-1 receptor antagonistPostendoscopic retrograde cholangiopancreatography pancreatitisTranscription factor nuclear factor-kappaBPancreatic duct stentingPrimary sensory neuronsUse of cytokinesHigh-risk peopleCyclo-oxygenase-2Use of diclofenacRegulation of inflammationFinal common pathwayNuclear factor-kappaBEarly eventsDuct stentingLung injuryInflammatory inhibitorPancreatic inflammationCholangiopancreatography pancreatitisCytokine responsesPathologic activationSignificant morbidityMet-RANTESReceptor antagonist
2002
Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis
Gukovskaya AS, Vaquero E, Zaninovic V, Gorelick FS, Lusis AJ, Brennan M, Holland S, Pandol SJ. Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology 2002, 122: 974-984. PMID: 11910350, DOI: 10.1053/gast.2002.32409.Peer-Reviewed Original ResearchConceptsIntrapancreatic trypsin activationAcute pancreatitisNADPH oxidaseTrypsin activationAdenine Dinucleotide Phosphate OxidaseParenchymal cell injuryExperimental acute pancreatitisNADPH oxidase activityPancreatic acinar tissueDigestive enzymesWestern blot analysisAntineutrophil serumPathologic activationCell injuryPancreatitisExperimental pancreatitisHigh dosesMarked attenuationNeutrophilsAbstractTextAcinar tissuePancreatic homogenatesReactive oxygen speciesMyeloperoxidaseMice