2012
Sterile Inflammatory Response in Acute Pancreatitis
Hoque R, Malik AF, Gorelick F, Mehal WZ. Sterile Inflammatory Response in Acute Pancreatitis. Pancreas 2012, 41: 353-357. PMID: 22415665, PMCID: PMC3306133, DOI: 10.1097/mpa.0b013e3182321500.Peer-Reviewed Original ResearchConceptsDamage-associated molecular patternsSterile inflammatory responseAcute pancreatitisInterleukin-1βInflammatory responseExperimental pancreatitisNOD-like receptor protein 3High mobility group box protein 1Toll-like receptor 4Remote organ injuryReceptor protein 3Acinar cellsExperimental acute pancreatitisIL-1 receptorNovel therapeutic targetBox protein 1Necrotic acinar cellsDAMP receptorsShock protein 70Disease resolutionPancreatic injuryOrgan injuryInitial injuryIL-18Pharmacologic antagonism
2002
Acute pancreatitis
Nagar AB, Gorelick FS. Acute pancreatitis. Current Opinion In Gastroenterology 2002, 18: 552-557. PMID: 17033332, DOI: 10.1097/00001574-200209000-00005.Peer-Reviewed Original ResearchSystemic inflammatory responseAcute pancreatitisInflammatory responseDistant organ failureMultiple inciting factorsEndoscopic retrograde cholangiopancreatography (ERCP) resultsSpecific inflammatory mediatorsAcute pancreatic injuryHuman acute pancreatitisExperimental acute pancreatitisIntra-acinar activationRelease of cytokinesClinical acute pancreatitisMultiorgan failurePancreatic injuryOrgan failureProinflammatory mediatorsInflammatory mediatorsCascade of eventsClinical syndromePancreatitisAnimal modelsInciting factorsMajor determinantMediators