2022
492. Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of Aging and HIV-infection
Zapata H, Kumar A, Wang J, Shaw A, Zhou H, Radcliffe C, Barakat L, Vander Wyk B, Allore H, Zhao H, Tsang S, Manager D, Mohanty S. 492. Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of Aging and HIV-infection. Open Forum Infectious Diseases 2022, 9: ofac492.550. PMCID: PMC9751937, DOI: 10.1093/ofid/ofac492.550.Peer-Reviewed Original ResearchDistinct inflammatory signatureIntracellular cytokine stainingPro-inflammatory phenotypeDendritic cellsHIV infectionInflammatory signatureInnate immune pattern recognition receptorsHIV-positive older adultsImmune pattern recognition receptorsOlder adultsDectin-1 functionDendritic cell signatureMonocytes of HIVCohort of HIVPro-inflammatory environmentInnate immune cellsIFN-γ responsesDectin-1 stimulationSetting of agingMTORC-1Whole glucan particleDistinct gene signaturesPattern recognition receptorsDectin-1 agonistCytokine staining
2019
Effects of Aging on Human Toll-Like Receptor Function
Shaw A. Effects of Aging on Human Toll-Like Receptor Function. 2019, 981-992. DOI: 10.1007/978-3-319-99375-1_98.Peer-Reviewed Original ResearchInnate immune pattern recognition receptorsPattern recognition receptorsImmune pattern recognition receptorsToll-like receptorsTLR functionAdaptive immunityImmune systemEndogenous ligandAge-related chronic inflammationToll-like receptor functionT cell responsesInnate immune primingInnate immune systemAge-associated alterationsCombination of alterationsAge-related changesEffect of ageDendritic cellsInflammatory dysregulationChronic inflammationImmune primingRecognition receptorsCell responsesReceptor functionOlder adults
2018
Effects of Aging on Human Toll-Like Receptor Function
Shaw A. Effects of Aging on Human Toll-Like Receptor Function. 2018, 1-12. DOI: 10.1007/978-3-319-64597-1_98-1.Peer-Reviewed Original ResearchInnate immune pattern recognition receptorsPattern recognition receptorsImmune pattern recognition receptorsToll-like receptorsTLR functionAdaptive immunityImmune systemEndogenous ligandAge-related chronic inflammationToll-like receptor functionT cell responsesInnate immune primingInnate immune systemAge-associated alterationsCombination of alterationsAge-related changesEffect of ageDendritic cellsInflammatory dysregulationChronic inflammationImmune primingRecognition receptorsReceptor functionOlder adultsYoung adultsImpact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in Monocytes
Zapata HJ, Van Ness PH, Avey S, Siconolfi B, Allore HG, Tsang S, Wilson J, Barakat L, Mohanty S, Shaw AC. Impact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in Monocytes. The Journals Of Gerontology Series A 2018, 74: 794-801. PMID: 30239628, PMCID: PMC6521921, DOI: 10.1093/gerona/gly209.Peer-Reviewed Original ResearchConceptsPro-inflammatory environmentHIV infectionInnate immune pattern recognition receptorsPeripheral blood mononuclear cellsImmune pattern recognition receptorsCohort of HIVC-type lectin receptorsBlood mononuclear cellsMulticolor flow cytometryC-type lectin receptor MinclePattern recognition receptorsIL-10IL-12Cytokine productionIL-6Mononuclear cellsImmune responseHost responseCord factorFlow cytometryM. tuberculosisLectin receptorsMycobacterium tuberculosisOlder adultsImpact of aging