2022
492. Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of Aging and HIV-infection
Zapata H, Kumar A, Wang J, Shaw A, Zhou H, Radcliffe C, Barakat L, Vander Wyk B, Allore H, Zhao H, Tsang S, Manager D, Mohanty S. 492. Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of Aging and HIV-infection. Open Forum Infectious Diseases 2022, 9: ofac492.550. PMCID: PMC9751937, DOI: 10.1093/ofid/ofac492.550.Peer-Reviewed Original ResearchDistinct inflammatory signatureIntracellular cytokine stainingPro-inflammatory phenotypeDendritic cellsHIV infectionInflammatory signatureInnate immune pattern recognition receptorsHIV-positive older adultsImmune pattern recognition receptorsOlder adultsDectin-1 functionDendritic cell signatureMonocytes of HIVCohort of HIVPro-inflammatory environmentInnate immune cellsIFN-γ responsesDectin-1 stimulationSetting of agingMTORC-1Whole glucan particleDistinct gene signaturesPattern recognition receptorsDectin-1 agonistCytokine staining
2010
Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response
Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L, Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, Shaw AC. Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response. The Journal Of Immunology 2010, 184: 2518-2527. PMID: 20100933, PMCID: PMC3867271, DOI: 10.4049/jimmunol.0901022.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAntibodies, ViralCytokinesDendritic CellsFemaleFlow CytometryHumansInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesInterleukin-12 Subunit p40Interleukin-6Linear ModelsMaleMiddle AgedReverse Transcriptase Polymerase Chain ReactionToll-Like ReceptorsTumor Necrosis Factor-alphaYoung AdultConceptsPrimary human dendritic cellsDendritic cellsHuman dendritic cellsMyeloid DCsPlasmacytoid DCsCytokine productionTLR functionTNF-alphaIntracellular cytokine productionPoor Ab responsesInfluenza vaccine responsesMyeloid dendritic cellsPlasmacytoid dendritic cellsYoung individualsIntracellular cytokine stainingIL-12 productionIFN-alpha productionTLR ligand stimulationTLR gene expressionInnate immune responseAge-Associated DecreaseTLR8 engagementInfluenza immunizationAge-associated effectsCytokine staining