2022
CAV2.3 expression is upregulated in the substantia nigra pars compacta of humans with Parkinson's disease
Sharifi P, Bae H, Gveric D, Gentleman S, Smith P, Tierney T, Alavian K. CAV2.3 expression is upregulated in the substantia nigra pars compacta of humans with Parkinson's disease. Brain Disorders 2022, 5: 100031. DOI: 10.1016/j.dscb.2022.100031.Peer-Reviewed Original Research
2007
Transcriptional regulation of mesencephalic dopaminergic neurons: The full circle of life and death
Alavian KN, Scholz C, Simon HH. Transcriptional regulation of mesencephalic dopaminergic neurons: The full circle of life and death. Movement Disorders 2007, 23: 319-328. PMID: 18044702, DOI: 10.1002/mds.21640.BooksConceptsTranscription factorsMesencephalic dopaminergic neuronsDopaminergic neuronsLmx1a/bTranscriptional regulationMolecular mechanismsEssential processCellular propertiesSynapse formationDisease mechanismsNeurotransmitter phenotypeLong-term survivalIntense investigationTarget innervationVentral midbrainParkinson's diseaseNeuronal populationsNeurodegenerative ailmentsNeuronsGenesDiseasePitx3PhenotypeNurr1Regulation
2006
Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice
Sgadò P, Albéri L, Gherbassi D, Galasso SL, Ramakers GM, Alavian KN, Smidt MP, Dyck RH, Simon HH. Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 15242-15247. PMID: 17015829, PMCID: PMC1622807, DOI: 10.1073/pnas.0602116103.Peer-Reviewed Original ResearchConceptsDopaminergic neuronsProgressive degenerationParkinson's diseaseMutant miceEngrailed-1Postnatal mutant miceSlow progressive degenerationNigral dopaminergic neuronsMesencephalic dopaminergic neuronsRelease of dopamineKey pathological featureLower body weightMotor deficitsPathological featuresSubstantia nigraCaudate putamenNovel treatmentsBody weightNeurodegenerative disordersHeterozygous nullDiseaseMiceNeuronsMolecular etiologyDependent manner