2022
Kidney Cysts in Hypophosphatemic Rickets With Hypercalciuria: A Case Series
Hanna C, Potretzke T, Chedid M, Rangel L, Arroyo J, Zubidat D, Tebben P, Cogal A, Torres V, Harris P, Sas D, Lieske J, Milliner D, Chebib F. Kidney Cysts in Hypophosphatemic Rickets With Hypercalciuria: A Case Series. Kidney Medicine 2022, 4: 100419. PMID: 35386604, PMCID: PMC8978140, DOI: 10.1016/j.xkme.2022.100419.Peer-Reviewed Original ResearchUrinary stone diseaseCYP24A1 deficiencyKidney cystsHypophosphatemic ricketsPathogenic variantsStone diseaseAge- and sex-matched control populationElevated 1,25-dihydroxyvitamin D levelSex-matched control populationActive vitamin DHereditary hypophosphatemic ricketsCystic kidney diseaseClinical presentationCase seriesD levelsAdult patientsAbstractText Label="RATIONALEAbstractText Label="RESULTS"HypercalciuriaPhosphate wastingVitamin DHHRHMedian numberAbstractText Label="ConclusionsFamily history
2021
Variable Clinical Presentation of Children With Hereditary Hypophosphatemic Rickets With Hypercalciuria: A Case Series
Christensen S, Tebben P, Sas D, Creo A. Variable Clinical Presentation of Children With Hereditary Hypophosphatemic Rickets With Hypercalciuria: A Case Series. Journal Of The Endocrine Society 2021, 5: a708-a708. PMCID: PMC8090272, DOI: 10.1210/jendso/bvab048.1442.Peer-Reviewed Original ResearchYear old maleYear old femaleHereditary hypophosphatemic ricketsHypophosphatemic ricketsDihydroxyvitamin DSerum phosphorusPhosphate wastingVitamin DElevated 1,25-dihydroxyvitamin DRecurrent urinary stonesLower extremity painVariable clinical presentationLow serum phosphorusPatellofemoral pain syndromePhenotype-genotype correlationProximal renal tubular cellsRenal tubular cellsSLC34A3 geneRenal ultrasoundUrine phosphorusExtremity painPain syndromePresenting symptomsUrine phosphateBone symptomsChapter 10 Phosphatonins
Tebben P, Kumar R. Chapter 10 Phosphatonins. 2021, 215-233. DOI: 10.1016/b978-0-12-813073-5.00010-1.ChaptersSecreted frizzled-related protein 4X-linked hypophosphatemic ricketsPhosphorus balanceCell membrane integrityTumor-induced osteomalaciaFrizzled-related protein 4Fibroblast growth factor 23Matrix extracellular phosphoglycoproteinPhosphate homeostasisRenal phosphate reabsorptionPhosphate absorptionAbnormal phosphate homeostasisIntestinal phosphate absorptionMembrane integrityPhosphorusFibroblast growth factor 7Parathyroid hormonePhosphaturic peptidesHypophosphatemic ricketsPhosphate reabsorptionVitamin DRenal reabsorptionHypophosphatemic disordersNovel treatmentTumoral calcinosis
2018
Chapter 26 Vitamin D and the Kidney
Tebben P, Kumar R. Chapter 26 Vitamin D and the Kidney. 2018, 437-459. DOI: 10.1016/b978-0-12-809965-0.00026-4.ChaptersVitamin D receptorPlasma membrane calciumCalcium transport systemEpithelial calcium channelCalbindin-D28KConservation of calciumPhosphorus transportCalcium channelsEfficiency of calciumPhosphorus reabsorptionCalbindin-D9KVitamin DD receptorProximal nephronMembrane calciumTransport systemD28KPhosphorusNephronKidneyCalbindin
2016
Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment
Tebben P, Singh R, Kumar R. Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment. Endocrine Reviews 2016, 37: 521-547. PMID: 27588937, PMCID: PMC5045493, DOI: 10.1210/er.2016-1070.Peer-Reviewed Original ResearchConceptsVitamin D receptorD receptorVitamin D-mediated hypercalcemiaElevated serum calcium concentrationsAssociated with elevated serumProduction of 1,25-dihydroxyvitamin DSuppressing PTH concentrationsAssociated with malignancyReduced bone densityRenal stone formersSerum calcium concentrationVitamin D metabolitesVitamin D<sub>3</sub>Primary hyperparathyroidismElevated serumPTH concentrationsMonoallelic mutationsClinical featuresCYP24A1 geneD metabolitesGranulomatous diseaseBiochemical diagnosisTumor cellsVitamin DHypercalcemia
2011
Chapter 26 Vitamin D and the Kidney
Tebben P, Kumar R. Chapter 26 Vitamin D and the Kidney. 2011, 471-491. DOI: 10.1016/b978-0-12-381978-9.10026-5.ChaptersControl of plasma calciumControl of plasma phosphateConservation of calciumCytochrome P-450-containing enzymeParathyroid hormoneEpithelial calcium channelPlasma calciumPhosphorusLoad of sodiumReabsorption of calciumReabsorption of phosphatePlasma membrane calciumRenal proximal tubular cellsCalcium transport systemPlasma phosphateProximal tubular cellsHormonal form of vitamin D.Synthesis of 1,25(OH)2D3Calbindin-D28KEfficiency of calciumCalcium channelsPhosphorus reabsorptionCalbindin-D9KVitamin DVitamin D.