2023
Crosstalk within a brain-breast-bone axis regulates mineral and skeletal metabolism during lactation
Athonvarangkul D, Wysolmerski J. Crosstalk within a brain-breast-bone axis regulates mineral and skeletal metabolism during lactation. Frontiers In Physiology 2023, 14: 1121579. PMID: 36875035, PMCID: PMC9979219, DOI: 10.3389/fphys.2023.1121579.Peer-Reviewed Original ResearchBone lossExcess bone lossExcessive bone lossPostmenopausal osteoporosisBone turnoverRare entityMineral metabolismSkeletal metabolismNew therapiesBone qualityCalcium demandOsteoporosisMammary glandCalcium deliveryBone axisReversible physiological responseLactationHormonal signalsCurrent knowledgeMetabolismPhysiological responsesPregnancyHypothalamusPathophysiologyTherapy
2014
Role of PTHrP in Mammary Gland Development and Breast Cancer
Hiremath M, Wysolmerski J. Role of PTHrP in Mammary Gland Development and Breast Cancer. Clinical & Translational Metabolism 2014, 12: 178-189. DOI: 10.1007/s12018-014-9170-9.Peer-Reviewed Original ResearchRole of PTHrPBreast cancerMammary glandOsteolytic bone lesionsPrimary breast cancerBreast cancer metastasisNormal mammary glandMammary cell fateMammary gland developmentMaternal calciumBone lesionsPrimary tumorMineral metabolismEmbryonic mammary developmentBreast pathogenesisNeonatal bonePTHrPMammary developmentCancer metastasisGland developmentSupply of calciumCancerGlandProtein signalingBone
2013
Osteocytes remove and replace perilacunar mineral during reproductive cycles
Wysolmerski JJ. Osteocytes remove and replace perilacunar mineral during reproductive cycles. Bone 2013, 54: 230-236. PMID: 23352996, PMCID: PMC3624069, DOI: 10.1016/j.bone.2013.01.025.BooksConceptsBone lossLevels of PTHrPNegative calcium balanceLevels of estrogenPrincipal bone-resorbing cellsSkeletal calcium storesBone-resorbing cellsPTHrP levelsBone turnoverBone resorptionBone massMineral metabolismCalcium balanceRole of osteocytesCalcium storesMineral homeostasisOsteocytic osteolysisReproductive cycleOsteocytesSystemic demandsPericanalicular matrixCalciumLactationBone
2010
Interactions between breast, bone, and brain regulate mineral and skeletal metabolism during lactation
Wysolmerski JJ. Interactions between breast, bone, and brain regulate mineral and skeletal metabolism during lactation. Annals Of The New York Academy Of Sciences 2010, 1192: 161-169. PMID: 20392232, PMCID: PMC3777748, DOI: 10.1111/j.1749-6632.2009.05249.x.Books
2007
Conversations between breast and bone: Physiological bone loss during lactation as evolutionary template for osteolysis in breast cancer and pathological bone loss after menopause
Wysolmerski J. Conversations between breast and bone: Physiological bone loss during lactation as evolutionary template for osteolysis in breast cancer and pathological bone loss after menopause. BoneKEy Reports 2007, 4: 209-225. DOI: 10.1138/20070268.Peer-Reviewed Original ResearchBone lossBone resorptionBreast cancerParathyroid hormone-related proteinLow estrogen levelsPathological bone resorptionPost-menopausal womenPathological bone lossCalcium-sensing receptorPhysiological bone lossHormone-related proteinSkeletal calcium storesHypothalamic hypogonadismPTHrP levelsEstrogen levelsPTHrP productionSkeletal demineralizationMineral metabolismSkeletal responseBone diseaseNew therapiesCalcium storesBone recoveryBreastCalcium transport
2002
The Evolutionary Origins of Maternal Calcium and Bone Metabolism During Lactation
Wysolmerski JJ. The Evolutionary Origins of Maternal Calcium and Bone Metabolism During Lactation. Journal Of Mammary Gland Biology And Neoplasia 2002, 7: 267-276. PMID: 12751891, DOI: 10.1023/a:1022800716196.BooksConceptsLower vertebratesEvolutionary originEutherian mammalsBone metabolismBone resorptionMaternal adaptationDifferent speciesMammalsMaternal calcium homeostasisRenal calcium excretionVertebratesAbsorption of calciumCalcium homeostasisEgg productionMetabolismMaternal calciumCalcium excretionHuman pregnancyMaternal transferCalcium metabolismFetal growthMineral metabolismNursing mothersAdaptationPregnancy