2022
Pathophysiology and management of hypoglycemia in diabetes
Sanchez‐Rangel E, Deajon‐Jackson J, Hwang JJ. Pathophysiology and management of hypoglycemia in diabetes. Annals Of The New York Academy Of Sciences 2022, 1518: 25-46. PMID: 36202764, DOI: 10.1111/nyas.14904.Peer-Reviewed Original ResearchConceptsType 1 diabetes mellitusCounter-regulatory hormonal responsesMechanism of hypoglycemiaDuration of diabetesManageable chronic diseaseOptimal glycemic controlManagement of hypoglycemiaTreatment of hypoglycemiaNew insulin formulationsDiscovery of insulinGlycemic controlDiabetes mellitusTherapeutic optionsBrain glucoseChronic diseasesNovel therapiesDiabetes managementHypoglycemiaPharmacologic targetHormonal responsesInsulin formulationsDiabetesPatientsCurrent literatureDelivery devices
2020
Glycemic Variability and CNS Inflammation: Reviewing the Connection
Watt C, Sanchez-Rangel E, Hwang JJ. Glycemic Variability and CNS Inflammation: Reviewing the Connection. Nutrients 2020, 12: 3906. PMID: 33371247, PMCID: PMC7766608, DOI: 10.3390/nu12123906.Peer-Reviewed Original ResearchConceptsBlood-brain barrierGlycemic variabilityOxidative stressCentral nervous system outcomesImpact of hyperglycemiaType 2 diabetesCNS inflammationVascular complicationsVascular inflammationCognitive dysfunctionTherapeutic implicationsCognitive deficitsType 1Brain functionNeuroinflammationInflammationDysfunctionGlucoseLow levelsSystem outcomesHigh levelsComplicationsHyperglycemiaDiabetesLatest data
2017
The human brain produces fructose from glucose
Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS. The human brain produces fructose from glucose. JCI Insight 2017, 2: e90508. PMID: 28239653, PMCID: PMC5313070, DOI: 10.1172/jci.insight.90508.Peer-Reviewed Original ResearchConceptsPolyol pathwayFructose levelsIntracerebral glucoseBlood-brain barrierPathogenesis of obesityType 2 diabetesEffects of fructoseHuman brainRegression model analysisCNS deliveryCNS effectsHyperglycemic clampHealthy subjectsDietary consumptionGlucoseBaselineBrainMixed-effects regression model analysisFeeding behaviorMinutesCN productionObesityDiabetesLevelsPathogenesis