Moitrayee Bhattacharyya, PhD
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Assistant Professor of Pharmacology
Biography
The Bhattacharyya Lab studies molecular mechanism of kinase signaling, especially in the context of learning, memory and neuropathological conditions. Dr. Bhattacharyya received her PhD in Computational Biophysics at the Indian Institute of Science, Bangalore where she used molecular dynamics simulations and graph theory to study allosteric communication in proteins and its complexes with RNA/DNA. She made a transition into experimental biology during her postdoctoral studies at the University of California Berkeley as a Human Frontier Science Program Long Term Fellow. She used structural biology, single-molecule microscopy, and native mass spectrometry along with computational techniques to study the molecular mechanism of regulation in a calcium/calmodulin-dependent protein kinase that is critical for learning and memory. The Bhattacharyya Lab takes an integrative approach to understand the molecular mechanism of cellular signaling using both experimental and computational techniques.
Appointments
Pharmacology
Assistant ProfessorPrimary
Other Departments & Organizations
- Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)
- Interdepartmental Neuroscience Program
- Janeway Society
- Molecular Medicine, Pharmacology, and Physiology
- Neural Disorders
- Neuroscience Track
- Pharmacology
- Primary Faculty
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- Postdoc
- University of California Berkeley (2019)
- PhD
- Indian Institute of Science (2012)
Research
Academic Achievements and Community Involvement
Links & Media
Media
Fig. 2
SMALP-based purification of Trk receptor tyrosine kinase from cells with minimal perturbation to its endogenous lipid environment for spatial lipidomics analysis (to measure changes in the membrane lipid composition in the immediate vicinity of the kinase under different states of activation, ligand binding and disease-mutations), single-molecule studies and native-MS interrogation (to study the effect of the endogenous lipid environment on the organization and signaling of Trk receptor isoforms).Fig. 1
A molecular mechanistic investigation of the signaling pathways impli- cated in learning and memory and the pathologies of Down Syndrome like cognitive impairments and accelerated aging
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Contacts
Pharmacology
Sterling Hall of Medicine, B-Wing - 333 Cedar Street, SHM B316B
New Haven, CT 06510
United States
Locations
SHM B316B
Academic Office