Bruce Haffty, MD
About
Research
Publications
2025
Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation
Liu J, Shen Y, Liu J, Xu D, Chang C, Wang J, Zhou J, Haffty B, Zhang L, Bargonetti J, De S, Hu W, Feng Z. Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation. Nature Communications 2025, 16: 1762. PMID: 39971971, PMCID: PMC11839913, DOI: 10.1038/s41467-025-57099-9.Peer-Reviewed Original ResearchConceptsGain-of-functionTumor suppressive function of p53Mutp53 accumulationAccumulate to high levelsFunction of p53Mutant p53 accumulationTumor suppressive functionMutant p53Subcutaneous xenograft tumor modelMutp53Promote tumorigenesisP53 accumulationPalmitoylationPotential therapeutic strategyXenograft tumor modelFASNTumor modelTumor organoidsTransgenic miceTherapeutic strategiesP53If We Build It, Why They Do Not Come? An American College of Surgeons National Quality Improvement Collaborative to Understand Barriers to Completion of Cancer Treatment.
Janczewski L, Yang A, Reilly E, Chan K, Coates T, Scarlett S, Hedlund S, Snyder R, Haffty B, Shelton C, Kirstein L. If We Build It, Why They Do Not Come? An American College of Surgeons National Quality Improvement Collaborative to Understand Barriers to Completion of Cancer Treatment. JCO Oncology Practice 2025, op2400745. PMID: 39928902, DOI: 10.1200/op-24-00745.Peer-Reviewed Original ResearchAccredited cancer programsNational QI collaborativeCancer programsAt-risk patientsQI collaborativeCancer careNational quality improvement collaborativeProportion of at-risk patientsPercentage of at-risk patientsQuality improvementCompletion of cancer treatmentAmerican CollegeNational quality improvementQuality improvement collaborativePatients face barriersIdentifying at-risk patientsTests assessed differencesData collection periodUnderstanding barriersIdentified barriersRadiation treatmentCancer-specific outcomesImprove collaborationKruskal-Wallis tests assessed differencesMultiple radiation treatmentsSex-Based Bias in Industry Payments to Medical Oncologists
Jan I, De B, Kwon Y, Freeman R, Larkin K, Subramanian S, Pandu P, Song A, Young M, Sayan M, Beier M, Ludmir E, Vapiwala N, Haffty B, Mattes M. Sex-Based Bias in Industry Payments to Medical Oncologists. 2025 DOI: 10.1200/oa-24-00029.Peer-Reviewed Original ResearchMedical oncologistsNational Plan and Provider Enumeration SystemIndustry paymentsCenters for MedicareGeneral paymentsResearch paymentsNational Institutes of Health (NIHPractice locationIndustry research paymentsSex-based differencesSpeaker feesOncologistsNo significant sex differencesEnumeration systemSex-based biasOpen Payments databaseNIH RePORTERSex-basedInvestigate potential differencesSignificant sex differencesOncology researchResearch fundingPayments Database
2024
Predicting Radiation-Induced Acute Toxicity in Breast Cancer Patients: A Radiogenomic Approach
Wei S, Zhang Y, Sowmiyanarayanan S, Yehia Z, Jan I, Yue N, Haffty B, Nie K. Predicting Radiation-Induced Acute Toxicity in Breast Cancer Patients: A Radiogenomic Approach. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e341. DOI: 10.1016/j.ijrobp.2024.07.752.Peer-Reviewed Original ResearchBreast cancer patientsRadiation dermatitisSide effectsCancer patientsBreast cancer patients treated with radiationRadiogenomic approachCancer patients treated with radiationRadiation-induced acute toxicityPatients treated with radiationRadiomic featuresSingle nucleotide polymorphismsAcute radiation dermatitisBreast-conserving surgeryRadiation side effectsPeripheral blood samplesTotal radiation dosePersonalized treatment strategiesGenetic statusRadiation therapyMammographic patternsRadiomic texture featuresTherapy side effectsClinical parametersRetrospective studyClinical featuresPtcog International Survey of Practice Patterns and Trends in Utilization of Proton Therapy for Breast Cancer
Choi I, Abeloos C, Lozano A, Kim M, Hanlon A, Vargas C, Maduro J, Bradley J, Offersen B, Haffty B, Pankuch M, Amos R, Kim N, Kirova Y, Mutter R. Ptcog International Survey of Practice Patterns and Trends in Utilization of Proton Therapy for Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e742-e743. DOI: 10.1016/j.ijrobp.2024.07.1632.Peer-Reviewed Original ResearchRegional nodal irradiationParticle Therapy Co-Operative GroupBreast cancerBC patientsPractice patternsDose-fractionation regimensHighly-selected patientsProton beam therapyPatient selection criteriaPencil beam scanningFisher's exact testEvolution of practice patternsPatient selection methodsClinical trial enrollmentSurvey of practice patternsImage guidance capabilitiesTreated BC patientsHypofractionated regimensNodal irradiationRecurrent BCBeam therapyPatient selectionProton therapyU.S. centersExact testPre-Operative Boost Results in Low Rates of Re-Excision and Reduced Time from Initial Diagnosis to Completion of Local-Regional Treatment in Breast Cancer Patients
Chakraborty M, Sherwani Z, Yehia Z, Ohri N, Cui T, Eladoumikdachi F, Kowzun M, Kumar S, Potdevin L, Toppmeyer D, Haffty B. Pre-Operative Boost Results in Low Rates of Re-Excision and Reduced Time from Initial Diagnosis to Completion of Local-Regional Treatment in Breast Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s201-s202. DOI: 10.1016/j.ijrobp.2024.07.2265.Peer-Reviewed Original ResearchBreast-conserving surgeryWhole breast irradiationDuctal carcinoma in situRe-excision ratesProspective phase II clinical trialRate of re-excisionPhase II clinical trialRe-excisionII clinical trialsHypofractionated regimenWound complicationsPre-operativelyDiagnosis to completionTreated with breast-conserving surgeryClinical trialsInitiation of systemic therapyMedian clinical tumor sizeRisk of wound complicationsIncidence of wound complicationsEarly-stage breast cancerLocal-regional treatmentTumor bed boostClinical tumor sizeNode-positive diseaseCompletion of radiationClinical Outcomes in Breast Cancer Patients with Underlying Germline PALB2 Mutations Treated with Radiation
Shalaby A, Jan I, Ohri N, Yehia Z, Toppmeyer D, Haffty B. Clinical Outcomes in Breast Cancer Patients with Underlying Germline PALB2 Mutations Treated with Radiation. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e331-e332. DOI: 10.1016/j.ijrobp.2024.07.731.Peer-Reviewed Original ResearchBreast-conserving surgeryPALB2 variantsBreast cancer patientsInterpretations of pathogenicityClinical outcomesPathogenic variantsHypo-RTBreast cancer patients treated with radiationCancer patients treated with radiationCancer patientsRisk of radiation toxicitySentinel lymph node dissectionPatients treated with radiationMedical recordsPALB2 pathogenic variantsContralateral breast cancerExternal beam radiationMedian tumor sizeLymph node dissectionSuppression of cancer developmentGrade 2 fibrosisRecurrence 4 monthsMultigene panel testingDNA double-strand break repairDouble-strand break repairA Randomized Trial of Hypofractionated Post-Mastectomy Radiation Therapy (PMRT) in Women with Breast Reconstruction (RT CHARM, Alliance A221505)
Poppe M, Le-Rademacher J, Haffty B, Hansen E, Agarwal J, Wagner J, Kong I, Armer J, Arthur D, Whelan T, Lee M, Kour O, Lustberg M, Partridge A, Carey L, Ruddy K, Gaffney D, Stecklein S, Bernstein M, Khan A. A Randomized Trial of Hypofractionated Post-Mastectomy Radiation Therapy (PMRT) in Women with Breast Reconstruction (RT CHARM, Alliance A221505). International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s11. DOI: 10.1016/j.ijrobp.2024.07.002.Peer-Reviewed Original ResearchPost-mastectomy radiation therapyNeoadjuvant chemotherapyBreast reconstructionComplication rateReconstruction complicationsBreast cancerNon-inferiorityHigh-risk breast cancerBody mass index >Conventionally fractionated radiationGenetic predisposition genesImplant-only reconstructionsMedian follow-upImmediate breast reconstructionOne-sided type I errorNon-inferiority marginStandard of careHypofractionated radiationRegional recurrenceRadiation therapyTumor characteristicsInvasive BCAdjuvant chemotherapyPredisposition genesMedian ageFirst Results of the Primary Outcome of a Phase 2 Prospective Clinical Trial to Assess the Feasibility of Preoperative Radiation Boost in Patients With Breast Cancer
Yehia Z, Sherwani Z, Chakraborty M, Ohri N, Grann A, Eladoumikdachi F, Kowzun M, Kumar S, Potdevin L, Blackwood M, Toppmeyer D, Haffty B. First Results of the Primary Outcome of a Phase 2 Prospective Clinical Trial to Assess the Feasibility of Preoperative Radiation Boost in Patients With Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2024, 121: 333-340. PMID: 39241809, DOI: 10.1016/j.ijrobp.2024.08.043.Peer-Reviewed Original ResearchWhole breast RTBreast-conserving therapyBoost volumePostoperative RTRT boostPrimary outcomeBreast RTRadiation therapyCosmetic outcomeWound complicationsBreast cancerClinically node-negative breast cancerPhase II prospective clinical trialMedian clinical tumor sizePostoperative whole-breast RTProspective phase 2 trialIncidence of grade 3Node-negative breast cancerProspective phase 2 studyRate of postoperative wound complicationsDuctal carcinoma in situClinical tumor sizeCarcinoma in situPhase 2 studyPhase 2 trialPTCOG international survey of practice patterns and trends in utilization of proton therapy for breast cancer
Choi J, Hardy-Abeloos C, Lozano A, Hanlon A, Vargas C, Maduro J, Bradley J, Offersen B, Haffty B, Pankuch M, Amos R, Kim N, MacDonald S, Kirova Y, Mutter R. PTCOG international survey of practice patterns and trends in utilization of proton therapy for breast cancer. Clinical And Translational Radiation Oncology 2024, 48: 100847. PMID: 39280125, PMCID: PMC11399555, DOI: 10.1016/j.ctro.2024.100847.Peer-Reviewed Original ResearchProton beam therapyBreast cancer patientsParticle Therapy Co-Operative GroupPatient selection methodsBreast cancerCancer patientsTreat breast cancer patientsRegional nodal irradiationFisher's exact testSurvey of practice patternsModerate hypofractionationNodal irradiationRadiation oncologistsBeam therapyPBT patientsProton therapyExact testU.S. centersDescriptive statisticsEuropean centersPractice patternsPatientsResponding centersBreastAsian centers
News
News
- March 22, 2023
25 Years of Women’s Health Research at Yale
- December 25, 2017
Twenty years and counting for Women’s Health Research at Yale
- December 20, 2017Source: Medicine@Yale
Twenty years and counting for Women's Health Research at Yale
- September 15, 2009
Handbook of Radiation Oncology: Basic Principles and Clinical Protocols