2010
Rapid Chemical Antagonism of Neuromuscular Blockade by l-Cysteine Adduction to and Inactivation of the Olefinic (Double-bonded) Isoquinolinium Diester Compounds Gantacurium (AV430A), CW 002, and CW 011
Savarese JJ, McGilvra JD, Sunaga H, Belmont MR, Van Ornum SG, Savard PM, Heerdt PM. Rapid Chemical Antagonism of Neuromuscular Blockade by l-Cysteine Adduction to and Inactivation of the Olefinic (Double-bonded) Isoquinolinium Diester Compounds Gantacurium (AV430A), CW 002, and CW 011. Anesthesiology 2010, 113: 58-73. PMID: 20526187, DOI: 10.1097/aln.0b013e3181dc1b5b.Peer-Reviewed Original ResearchMeSH KeywordsAlkenesAnimalsAtracuriumChemical PhenomenaCholinesterase InhibitorsChromatography, High Pressure LiquidCysteineDose-Response Relationship, DrugDrug InteractionsEdrophoniumHaplorhiniIsoquinolinesMacaca mulattaMaleMaleatesNeostigmineNeuromuscular BlockadeNeuromuscular Blocking AgentsStructure-Activity RelationshipConceptsDuration of blockED95 dosesNeuromuscular blockadeNeuromuscular blockersNovel agentsTwitch inhibitionCysteine adductionGantacuriumExogenous L-cysteineIntermediate durationAdductionL-cysteineED95Preliminary dataBlockadeAntagonismChemical antagonismHigh-performance liquid chromatographyDurationMinRapid adductionAdduction productsCisatracuriumLiquid chromatographyBlockers
2001
Flow dependency of error in thermodilution measurement of cardiac output during acute tricuspid regurgitation
Heerdt P, Blessios G, Beach M, Hogue C. Flow dependency of error in thermodilution measurement of cardiac output during acute tricuspid regurgitation. Journal Of Cardiothoracic And Vascular Anesthesia 2001, 15: 183-187. PMID: 11312476, DOI: 10.1053/jcan.2001.21947.Peer-Reviewed Original ResearchConceptsAcute tricuspid regurgitationTricuspid regurgitationCardiac outputArteriovenous shuntsSevere regurgitationVenous returnPeripheral arteriovenous shuntsSevere tricuspid regurgitationThermodilution cardiac output measurementsAnesthetized mongrel dogsThermodilution cardiac outputCardiac output measurementsElectromagnetic flowMongrel dogsRegurgitationAnimal studiesThermodilution measurementsShuntThermodilutionVariable degreesMinimal effectMin