Paul Heerdt, PhD, MD
Professor of AnesthesiologyCards
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
About
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Titles
Professor of Anesthesiology
Director of Applied Hemodynamics, Anesthesiology
Biography
Paul M. Heerdt is a Professor of Anesthesiology at Yale University School of Medicine. Dr. Heerdt earned his MD from the University of Tennessee in 1982 followed by a PhD in cardiovascular pharmacology in 1985. He completed his residency in anesthesiology at Massachusetts General Hospital in Boston and then a fellowship in cardiothoracic anesthesia at Washington University in St. Louis, MO.
Following clinical training, Dr. Heerdt remained on the faculty at Washington University for several years before moving to Cornell University in 1992. At Cornell, he was a faculty member in the departments of Anesthesiology and Pharmacology and also maintained an appointment at Memorial Sloan Kettering Center. In 2016 Dr. Heerdt moved to Yale where he has been conducting clinical and basic science research with a particular emphasis on developing collaborative opportunities for residents, fellows, and junior faculty. He serves on several committees within the Yale School of Medicine and lectures in the medical student pharmacology curriculum. Outside of Yale, Dr. Heerdt is active in the Society of Cardiovascular Anesthesiologists and a member of the editorial board for the Journal of Pharmacology and Experimental Therapeutics.
Appointments
Education & Training
- Resident
- Massachusetts General Hospital (1988)
- Fellow
- Washington University (1988)
- PhD
- University of Tennessee, Pharmacology (1985)
- MD
- University of Tennessee College of Medicine (1982)
- BS
- Memphis State University (1978)
Board Certifications
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 1990
Research
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Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0002-9765-9885
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Inderjit Singh, MBChB, BMedSci, FRCP, FCCP, MD
Phillip Joseph, MD
Zyad James Carr, MD
Andres Brenes Bastos, MD
Hung-Mo Lin
Jean Gabriel Charchaflieh, MD, MPH, DrPH
Cardiovascular Diseases
Publications
2026
Stiff Left Atrial Syndrome: Hemodynamic Insights and a Noninvasive Diagnostic Approach
Haghani Rad N, Okasha O, Kwan J, Heerdt P, Singh I. Stiff Left Atrial Syndrome: Hemodynamic Insights and a Noninvasive Diagnostic Approach. Annals Of The American Thoracic Society 2026, aaoag163. PMID: 42295833, DOI: 10.1093/annalsats/aaoag163.Peer-Reviewed Original ResearchRight Ventricular End‐Ejection Pressure Predicts Mortality in Patients With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction
Tarras E, Arun A, Joseph P, Heerdt P, Singh I. Right Ventricular End‐Ejection Pressure Predicts Mortality in Patients With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. Comprehensive Physiology 2026, 16: e70187. PMID: 42210677, DOI: 10.1002/cph4.70187.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsArea under the receiver operating characteristic curveAssociated with mortalityPH-HFpEFRV pressureEjection fractionRetrospective studyHeart failureRight ventricular (RV) dysfunctionHemodynamic indicesPH-HFpEF patientsPulmonic valve closureRV pressure waveformsAssociated with all-cause mortalityAssociated with heart failurePreserved Ejection FractionKaplan-Meier analysisMultivariate Cox analysisDetermination of prognosisCox proportional hazards modelsReceiver operating characteristic curveAll-Cause MortalityLASSO-penalized logistic regressionCross-validated area under the receiver operating characteristic curveOperating characteristics curveProportional hazards modelComparative Pulmonary Artery Pressure Response between Large-Bore Thrombectomy and Catheter-Directed Thrombolysis in Patients with Intermediate-High- and High-Risk Pulmonary Embolism
Conte M, Khosla A, Singh I, Hur J, Pollak J, Mojibian H, Marino A, Heerdt P, Cornman-Homonoff J. Comparative Pulmonary Artery Pressure Response between Large-Bore Thrombectomy and Catheter-Directed Thrombolysis in Patients with Intermediate-High- and High-Risk Pulmonary Embolism. Journal Of Vascular And Interventional Radiology 2026, 37: 108863. PMID: 42177020, DOI: 10.1016/j.jvir.2026.108863.Peer-Reviewed Original ResearchConceptsChronic thromboembolic pulmonary hypertensionCatheter-directed thrombolysisPulmonary artery pressurePE-related outcomesHigh-risk pulmonary embolismPulmonary embolismAdverse eventsCatheter-directed thrombolysis groupMean body mass indexPulmonary artery pressure responseIntermediate-highThromboembolic pulmonary hypertensionPE-related mortalityPE-related deathPeriprocedural adverse eventsCatheter-based therapiesPeriprocedural complication rateRight atrial pressureBody mass indexHemodynamic responseArterial pressure responseAssociated with greater oddsPE recurrencePropensity score matchingPulmonary hypertensionReply to Sbarra et al.
Oakland H, Heerdt P, Hunter K, Singh I. Reply to Sbarra et al. AJP Heart And Circulatory Physiology 2026, 330: h1711-h1712. PMID: 42065598, DOI: 10.1152/ajpheart.00243.2026.Commentaries, Editorials and LettersC64-06 Right Ventricular End-Ejection Pressure Predicts Mortality in Patients With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction
Tarras E, Arun A, Heerdt P, Singh I. C64-06 Right Ventricular End-Ejection Pressure Predicts Mortality in Patients With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.1568. DOI: 10.1093/ajrccm/aamag162.1568.Peer-Reviewed Original ResearchConceptsPulmonic valve closurePulmonary vascular resistancePredictors of mortalityPulmonary arterial compliancePH-HFpEFHemodynamic predictorsNT-proBNPCpc-PHPulmonary hypertensionEjection fractionIpc-PHRV pressureHeart failureAtrial pressureRight ventricular (RV) afterloadMean pulmonary artery pressureCox modelCpc-PH patientsHigher NT-proBNPPH-HFpEF patientsRV pressure waveformsAssociated with heart failureRight heart catheterizationElevating left atrial pressureLow cardiac outputEchocardiographic Correlates of Pressure-Volume-Derived Indices: Advancing Intraoperative Assessment of Right Ventricular Function
Kiarad V, Ahmed U, Heerdt P, Mahmood F, Moaddab M, Liu D, Senthilnathan V, Kai M, Chu L, Khabbaz K. Echocardiographic Correlates of Pressure-Volume-Derived Indices: Advancing Intraoperative Assessment of Right Ventricular Function. JTCVS Open 2026, 101712. DOI: 10.1016/j.xjon.2026.101712.Peer-Reviewed Original ResearchConceptsRV-PA couplingImpaired RV-PA couplingRV-PACardiac surgeryEchocardiographic measurementsEchocardiographic measures of right ventricular (RV) functionRight ventricular (RV) functionAssessment of right ventricular functionMeasures of right ventricular (RV) functionIntraoperative assessmentAdult cardiac surgery patientsPulmonary artery catheter monitoringRight ventricular functionCardiac surgery patientsIntraoperative three-dimensionalSTS risk scoreImpaired couplingProspective observational studySingle-beat methodMultivariate logistic regressionRV volumesTransesophageal echocardiographyVentricular functionEchocardiographic variablesPressure-volume analysis3D echo derived right ventricular principal surface strain in pulmonary arterial hypertension
Oakland H, Bellumkonda L, Sugeng L, Joseph P, Kundu P, Izzi D, Zalik F, McCabe S, Raza A, Amendola R, Heerdt P, Hunter K, Singh I. 3D echo derived right ventricular principal surface strain in pulmonary arterial hypertension. AJP Heart And Circulatory Physiology 2026, 330: h729-h736. PMID: 41616802, PMCID: PMC13097151, DOI: 10.1152/ajpheart.00923.2025.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPulmonary arterial hypertension patientsPulmonary arterial hypertensionRV systolic functionRight heart catheterizationSystolic functionEchocardiographic representationArterial hypertensionControl patientsOptimal cutoffRight heartNew York Heart Association functional classRight ventricular (RV) functionTricuspid annular plane systolic excursionAnnular plane systolic excursionFunctional classLongitudinal systolic functionThirty-day outcomesSystolic excursionPAH patientsRV functionHeart catheterizationPrognostic valueThirty-dayHemodynamic criteriaRobust markersProximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
De Man R, Cai Z, Doddaballapur P, Guerrera N, Regan A, Lin L, Schwarz E, Justet A, Abu Hussein N, Di Palo J, Cavinato C, Raredon M, Heerdt P, Singh I, Yan X, Kang M, Bruns D, Lee P, Tellides G, Humphrey J, Kaminski N, Ramachandra A, Manning E. Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging. Aging Cell 2026, 25: e70383. PMID: 41589414, PMCID: PMC12836046, DOI: 10.1111/acel.70383.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProximal pulmonary arteriesPulmonary arterySmooth muscle cellsPerivascular macrophagesMouse modelMuscle cellsRight ventricle functionMedial smooth muscle cellsPulmonary arterial stiffeningRight ventricleVentricle functionAssociated with senescenceECM turnoverLung functionArterial stiffeningArteryAdventitial fibroblastsMolecular targetsAge-relatedGeroscience hypothesisLungAgeIntercellular signalingMiceMacrophagesRelationship of cardiac MRI-derived pulmonary arterial stiffness markers and invasive hemodynamic
Buber I, Heerdt P, Singh I, Phillip J, Sevgican C, Lamy J, Xiang J, Peters D. Relationship of cardiac MRI-derived pulmonary arterial stiffness markers and invasive hemodynamic. The International Journal Of Cardiovascular Imaging 2026, 1-9. PMID: 41484521, DOI: 10.1007/s10554-025-03589-2.Peer-Reviewed Original ResearchConceptsRight heart catheterizationPulmonary artery stiffnessPulse wave velocityRelative area changeCardiac magnetic resonancePulmonary hypertensionPost-capillaryRight heart catheterization measurementsDisease severityRight ventricular pressureBiomarkers associated with disease severityMixed venous saturationArterial stiffness markersPH subgroupsHeart catheterizationPH subtypesPulmonary arteryRetrospective studyNoninvasive markerProspective studyImpaired hemodynamicsVenous saturationHemodynamic parametersClinical utilityArterial stiffness
2025
Correction: Essential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period
McEvoy M, Heerdt P, Morton V, Bartz R, Miller T. Correction: Essential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period. Perioperative Medicine 2025, 14: 134. PMID: 41316494, PMCID: PMC12664171, DOI: 10.1186/s13741-025-00608-7.Commentaries, Editorials and Letters
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