2024
Pulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis
Tatsuoka Y, Carr Z, Jayakumar S, Lin H, He Z, Farroukh A, Heerdt P. Pulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis. Journal Of Clinical Medicine 2024, 13: 1996. PMID: 38610760, PMCID: PMC11012853, DOI: 10.3390/jcm13071996.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsLength of stayPulmonary hypertensionPulmonary complicationsPulmonary embolismRespiratory failureEndoscopic proceduresRisk of postoperative complicationsPulmonary artery pressurePreoperative risk assessmentProlonged length of stayRetrospective cohort studySub-cohort analysisIncreased LOSPropensity score overlap weightingOverlap weightingAssociation of PHPH cohortPH patientsPostoperative complicationsAbdominal surgeryRate of RFCohort studyControl cohortArterial pressure
2019
Automated expiratory ventilation assistance through a small endotracheal tube can improve venous return and cardiac output
Berlin DA, Manoach S, Oromendia C, Heerdt PM. Automated expiratory ventilation assistance through a small endotracheal tube can improve venous return and cardiac output. Intensive Care Medicine Experimental 2019, 7: 6. PMID: 30627962, PMCID: PMC6326914, DOI: 10.1186/s40635-018-0217-y.Peer-Reviewed Original ResearchConventional positive pressure ventilationExpiratory ventilation assistancePositive pressure ventilationSmall endotracheal tubeMedian cardiac outputVenous returnCardiac outputPressure ventilationEndotracheal tubeArterial pressureConventional ventilationVentilation assistanceLow central venous pressureCentral venous pressureSystemic arterial pressureEVA groupPEEP 0Venous pressureExpiratory pressureStroke volumeControl groupPorcine modelEffective ventilationVentilationHemorrhage
2018
Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine.
Savarese JJ, Sunaga H, McGilvra JD, Belmont MR, Murrell MT, Jeannotte E, Cooke FE, Wastila WB, Heerdt PM. Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine. Anesthesiology 2018, 129: 970-988. PMID: 30212413, DOI: 10.1097/aln.0000000000002408.Peer-Reviewed Original ResearchConceptsNeuromuscular blocking agentsMean arterial pressureBlocking agentArterial pressureNeuromuscular blockadeHeart rateNew neuromuscular blocking agentRhesus monkeysNondepolarizing neuromuscular blocking agentDuration of actionStudy of bolusCirculatory effectsPreclinical pharmacologyControl infusionInstitutional Animal CareED95Large dosesSpontaneous recoveryGantacuriumDose ratioL-cysteineInfusionBolusUse CommitteeRecovery interval
2016
Preclinical Pharmacology of CW002
Sunaga H, Savarese JJ, McGilvra JD, Heerdt PM, Belmont MR, Van Ornum SG, Murrell MT, Malhotra JK, Savard PM, Jeannotte E, Petty BJ, Allen E, Carnathan GW. Preclinical Pharmacology of CW002. Anesthesiology 2016, 125: 732-743. PMID: 27466033, DOI: 10.1097/aln.0000000000001254.Peer-Reviewed Original ResearchMean arterial pressureNeuromuscular blockadeArterial pressureNondepolarizing neuromuscular blocking agentDose ratioSympathetic autonomic responsesNeuromuscular blocking agentsNeuromuscular blocking propertiesRecovery intervalIncrease of HRSympathetic inhibitionBolus dosesCirculatory effectsPreclinical pharmacologyTwitch inhibitionBlocking agentStudy of safetyInstitutional Animal CareAnesthetized monkeysHeart rateSpontaneous recoveryED95CW002Autonomic responsesRapid reversal
2010
Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs
Heerdt PM, Malhotra JK, Pan BY, Sunaga H, Savarese JJ. Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs. Anesthesiology 2010, 112: 910-916. PMID: 20234311, DOI: 10.1097/aln.0b013e3181d31f71.Peer-Reviewed Original ResearchConceptsX ED95Neuromuscular blocking drugsCardiopulmonary side effectsVascular resistanceArterial pressureBlocking drugsCardiac outputHistamine releaseSide effectsMean pulmonary artery pressurePulmonary artery pressurePulmonary vascular resistanceSystemic vascular resistanceMean arterial pressurePulmonary arterial pressureArtery pressureHemodynamic effectsPulmonary complianceVentricular contractilityInspiratory pressureNeuromuscular blockadeVentricular pressureED95Large dosesCW002Cysteine Reversal of the Novel Neuromuscular Blocking Drug CW002 in Dogs
Sunaga H, Malhotra JK, Yoon E, Savarese JJ, Heerdt PM. Cysteine Reversal of the Novel Neuromuscular Blocking Drug CW002 in Dogs. Anesthesiology 2010, 112: 900-909. PMID: 20234310, DOI: 10.1097/aln.0b013e3181d31f8c.Peer-Reviewed Original ResearchConceptsOrgan toxicityHeart rateIsoflurane-nitrous oxide anesthesiaAcute cardiovascular effectsNeuromuscular blocking drugsDose-response relationshipDose-dependent mannerEndogenous L-cysteineCardiovascular effectsHemodynamic effectsMedian durationArterial pressureBlood pressureBlocking drugsHistologic evidenceNeuromuscular blockadeOxide anesthesiaTwitch recoveryMuscle recoveryHistopathologic analysisMuscle twitchLarge doseCW002Additional groupDose
2004
Cardiopulmonary Effects of the Novel Neuromuscular Blocking Drug GW280430A (AV430A) in Dogs
Heerdt PM, Kang R, The’ A, Hashim M, Mook RJ, Savarese JJ. Cardiopulmonary Effects of the Novel Neuromuscular Blocking Drug GW280430A (AV430A) in Dogs. Anesthesiology 2004, 100: 846-851. PMID: 15087619, DOI: 10.1097/00000542-200404000-00014.Peer-Reviewed Original ResearchConceptsX ED95Cardiopulmonary changesBolus dosingDirect myocardial depressionStable neuromuscular blockadeMean arterial pressurePlasma histamine concentrationCardiopulmonary side effectsNondepolarizing neuromuscularPulmonary vasoconstrictionArterial pressureCardiovascular effectsMyocardial depressionCardiopulmonary effectsHemodynamic measurementsInspiratory pressureNeuromuscular blockadePulmonary complianceAnesthetized dogsCardiopulmonary dataMale beaglesArterial bloodED95Heart rateSide effects
1996
Nitric oxide synthesis inhibition and right ventricular systolic function in swine
Heerdt P, Pleimann B. Nitric oxide synthesis inhibition and right ventricular systolic function in swine. Journal Of Cardiothoracic And Vascular Anesthesia 1996, 10: 909-914. PMID: 8969400, DOI: 10.1016/s1053-0770(96)80055-3.Peer-Reviewed Original ResearchConceptsRV end-diastolic pressureTotal arterial resistanceL-NAMERV afterloadPA elastanceArterial resistanceNitric oxide synthesis inhibitor NG-nitroNitric oxide synthesis inhibitionRight ventricular systolic functionL-arginine methyl esterMean PA pressurePulmonary arterial pressureRight ventricular contractilityVentricular systolic functionEnd-diastolic pressureIndex of contractilityPeak ejection rateUniversity animal laboratoryLarge pulmonary vesselsIndex of RVRV powerArterial pressureSystolic functionNG-nitroResistance vessels
1990
Prostaglandin E1 and intrapulmonary shunt in cardiac surgical patients with pulmonary hypertension
Heerdt P, Weiss C. Prostaglandin E1 and intrapulmonary shunt in cardiac surgical patients with pulmonary hypertension. The Annals Of Thoracic Surgery 1990, 49: 463-465. PMID: 2106846, DOI: 10.1016/0003-4975(90)90257-7.Peer-Reviewed Original ResearchConceptsPulmonary vascular resistancePulmonary capillary wedge pressureCapillary wedge pressurePulmonary arterial pressureSystemic vascular resistanceVascular resistanceIntrapulmonary shuntPulmonary hypertensionProstaglandin E1Wedge pressureArterial pressureSurgical patientsCardiac outputElevated pulmonary vascular resistanceMean pulmonary arterial pressureAdult respiratory distress syndromeMixed venous oxygen tensionPulmonary vascular responseCardiac surgical patientsRight atrial pressureRespiratory distress syndromeProstaglandin E1 infusionPulmonary arterial catheterRadial arterial cannulaVenous oxygen tension