1995
Enhancement of GABAA receptor-mediated conductances induced by nerve injury in a subclass of sensory neurons
Oyelese A, Eng D, Richerson G, Kocsis J. Enhancement of GABAA receptor-mediated conductances induced by nerve injury in a subclass of sensory neurons. Journal Of Neurophysiology 1995, 74: 673-683. PMID: 7472373, PMCID: PMC2605359, DOI: 10.1152/jn.1995.74.2.673.Peer-Reviewed Original ResearchConceptsDRG neuronsAction potential durationMedium neuronsNerve injurySmall neuronsLarge neuronsAction potentialsGABA conductanceNerve ligationControl neuronsPotential durationAdult rat dorsal root ganglion neuronsGABAA receptor-mediated conductanceRat dorsal root ganglion neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsDorsal root ganglion neuronsMean action potential durationShort-duration action potentialsControl DRG neuronsSciatic nerve ligationEffects of axotomyReceptor-mediated conductanceTraumatic nerve injuryPatch-clamp recordings
1993
Increased spike‐frequency adaptation and tea sensitivity in dorsal root fibers after sciatic nerve injury
Utzschneider D, Bhisitkhul R, Kocsis J. Increased spike‐frequency adaptation and tea sensitivity in dorsal root fibers after sciatic nerve injury. Muscle & Nerve 1993, 16: 958-963. PMID: 8355727, DOI: 10.1002/mus.880160912.Peer-Reviewed Original ResearchConceptsCompound action potentialDorsal root axonsNerve injuryDorsal rootsPotassium channel blockerAction potentialsSciatic nerveChannel blockersSpike adaptationSciatic nerve injuryPeripheral nerve injurySucrose gap chamberBrief tetanic stimulationDorsal root fibersWhole nerve recordingsSpike frequency adaptationTransection groupBurst dischargesTetanic stimulationNerve recordingsControl groupInjuryRoot fibersBurst responseNerve
1991
Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons
Utzschneider D, Kocsis J, Waxman S. Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons. Brain Research 1991, 551: 136-141. PMID: 1913145, DOI: 10.1016/0006-8993(91)90924-k.Peer-Reviewed Original ResearchConceptsDorsal columnsDorsal rootsAfferent fibersCentral nervous system componentsPrimary afferent fibersSucrose gap chamberAction potential amplitudePrimary afferent axonsCompound action potentialDorsal spinal rootsNervous system componentsAxonal trunksPeripheral nervesSpinal cordSpinal rootsAfferent axonsCNS portionSchwann cellsAdult ratsPotential amplitudeAxon branchesAction potentialsHypoxiaMembrane potential changesMembrane depolarization
1988
Buspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability
Hiner B, Mauk M, Peroutka S, Kocsis J. Buspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability. Brain Research 1988, 461: 1-9. PMID: 2906267, DOI: 10.1016/0006-8993(88)90719-6.Peer-Reviewed Original ResearchConceptsCerebellar parallel fibersSerotonergic mechanismsNerve excitabilityFiber excitabilityAction potentialsSucrose gap recordingsEffects of serotoninNovel anxiolytic buspironeCompound action potentialDose-dependent reductionSchaffer collateral fibersParallel fibersAfferent fibersSciatic nerveReversible decrementsCollateral fibersAnxiolytic buspironeConduction velocityDPATIpsapironeGap recordingsBuspironeCerebellar neuronsAxonal responseExcitabilityBuspirone attenuates synaptic activation of hippocampal pyramidal cells
Mauk, Peroutka S, Kocsis J. Buspirone attenuates synaptic activation of hippocampal pyramidal cells. Journal Of Neuroscience 1988, 8: 1-11. PMID: 3339401, PMCID: PMC6569355, DOI: 10.1523/jneurosci.08-01-00001.1988.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsPyramidal cellsStratum radiatumSynaptic activationAfferent fibersHippocampal CA1 pyramidal cellsInput resistanceStimulation of afferentsEffects of buspironeCA1 pyramidal cellsHippocampal pyramidal cellsPostsynaptic potentialsPresynaptic fibersConduction slowingFiber excitabilitySpike activityAnxiolytic agentsBuspironeRefractory periodRadiatumRapid hyperpolarizationReceptor sitesMeasurable effectExcitabilityMembrane potential
1984
Retrograde impulse activity and horseradish peroxidase tracig of nerve fibers entering neuroma studied in vitro
Kocsis J, Preston R, Targ E. Retrograde impulse activity and horseradish peroxidase tracig of nerve fibers entering neuroma studied in vitro. Experimental Neurology 1984, 85: 400-412. PMID: 6745381, DOI: 10.1016/0014-4886(84)90150-x.Peer-Reviewed Original Research
1983
The supernormal period of the cerebellar parallel fibers effects of [Ca2+]o and [K+]o
Malenka R, Kocsis J, Waxman S. The supernormal period of the cerebellar parallel fibers effects of [Ca2+]o and [K+]o. Pflügers Archiv - European Journal Of Physiology 1983, 397: 176-183. PMID: 6878005, DOI: 10.1007/bf00584354.Peer-Reviewed Original ResearchConceptsSupernormal periodConditioning stimulationActivity-dependent changesParallel fibersCerebellar parallel fibersConditioning volleyIon-sensitive microelectrodesConditioning stimulusExtracellular calciumLatency changesLatency shiftCortex exhibitExtracellular ionic concentrationsTest response latenciesTest latencyStimulationResponse latencyRelative increaseSmall increaseLatencyPeriodSuperfusateExcitabilityEffects of extracellular potassium concentration on the excitability of the parallel fibres of the rat cerebellum.
Kocsis J, Malenka R, Waxman S. Effects of extracellular potassium concentration on the excitability of the parallel fibres of the rat cerebellum. The Journal Of Physiology 1983, 334: 225-244. PMID: 6864558, PMCID: PMC1197311, DOI: 10.1113/jphysiol.1983.sp014491.Peer-Reviewed Original Research
1982
Effects of GABA on stimulus-evoked changes in [K+]o and parallel fiber excitability.
Malenka R, Kocsis J. Effects of GABA on stimulus-evoked changes in [K+]o and parallel fiber excitability. Journal Of Neurophysiology 1982, 48: 608-621. PMID: 6290614, DOI: 10.1152/jn.1982.48.3.608.Peer-Reviewed Original Research
1980
Effects of 4-aminopyridine on the frequency following properties of the parallel fibers of the cerebellar cortex
Kocsis J, Malenka R, Waxman S. Effects of 4-aminopyridine on the frequency following properties of the parallel fibers of the cerebellar cortex. Brain Research 1980, 195: 511-516. PMID: 6249447, DOI: 10.1016/0006-8993(80)90090-6.Peer-Reviewed Original Research