2007
Demyelinating diseases and potential repair strategies
Radtke C, Spies M, Sasaki M, Vogt PM, Kocsis JD. Demyelinating diseases and potential repair strategies. International Journal Of Developmental Neuroscience 2007, 25: 149-153. PMID: 17408905, PMCID: PMC2692731, DOI: 10.1016/j.ijdevneu.2007.02.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell TransplantationDemyelinating DiseasesDisease Models, AnimalHumansMyelin SheathNerve RegenerationConceptsMultiple sclerosisInjury modelSpinal cord injuryCell-based strategiesAxon lossNerve compressionNeuroprotective potentialCord injuryFunctional outcomeClinical studiesMS lesionsTherapeutic goalsVulnerable axonsCellular transplantationNeurological disordersDemyelinationRemyelinationNeuroprotectionPotential repair strategiesCell typesSclerosisTransplantationInjuryLesionsAxons
2006
Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells
Dombrowski MA, Sasaki M, Lankford KL, Kocsis JD, Radtke C. Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells. Brain Research 2006, 1125: 1-8. PMID: 17112480, PMCID: PMC2673087, DOI: 10.1016/j.brainres.2006.09.089.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCell Adhesion Molecules, NeuronalCell TransplantationGreen Fluorescent ProteinsImmunohistochemistryMicroscopy, ImmunoelectronMyelin SheathNAV1.6 Voltage-Gated Sodium ChannelNerve RegenerationNeurofilament ProteinsNeurogliaOlfactory BulbRanvier's NodesRatsRats, Sprague-DawleySciatic NeuropathySodium ChannelsTime FactorsConceptsPeripheral nerve fibersPeripheral nervesNodes of RanvierFunctional outcomeAxonal regenerationNerve fibersRegenerated peripheral nerve fibersSciatic nerve crush lesionNerve crush lesionPeripheral-type myelinSpinal cord resultsTransplantation of olfactoryPeripheral axonal regenerationParanodal CasprCrush lesionCord resultsFunctional improvementOlfactory bulbTransection siteTransgenic ratsLesion zoneNerveNodal formationTransplantation siteOECs
2001
Transplantation of Cryopreserved Adult Human Schwann Cells Enhances Axonal Conduction in Demyelinated Spinal Cord
Kohama I, Lankford K, Preiningerova J, White F, Vollmer T, Kocsis J. Transplantation of Cryopreserved Adult Human Schwann Cells Enhances Axonal Conduction in Demyelinated Spinal Cord. Journal Of Neuroscience 2001, 21: 944-950. PMID: 11157080, PMCID: PMC2605383, DOI: 10.1523/jneurosci.21-03-00944.2001.Peer-Reviewed Original ResearchConceptsHuman Schwann cellsSchwann cellsDorsal columnsSural nerveAxonal conductionIntra-axonal recording techniquesDorsal column lesionLegs of patientsDemyelinated spinal cordHuman sural nerveAdult human Schwann cellsFunctional remyelinationExtensive remyelinationCell-based therapiesMultiple sclerosisVascular diseaseSpinal cordWistar ratsConduction blockAdult CNSConduction velocityLesion zoneAction potentialsMonoclonal antibodiesLesions
2000
Transplantation of olfactory ensheathing cells or Schwann cells restores rapid and secure conduction across the transected spinal cord
Imaizumi T, Lankford K, Kocsis J. Transplantation of olfactory ensheathing cells or Schwann cells restores rapid and secure conduction across the transected spinal cord. Brain Research 2000, 854: 70-78. PMID: 10784108, DOI: 10.1016/s0006-8993(99)02285-4.Peer-Reviewed Original ResearchConceptsRegenerated axonsCell transplantationSpinal cordSchwann cellsTransection siteIsolated spinal cord preparationSpinal cord preparationTransplantation of olfactoryRat spinal cordSpinal cord axonsConduction velocity measurementsTransplantation of cellsCord preparationDorsal columnsAxonal regenerationAxon areaTransplantationImpulse conductionHost tractElectrophysiological recordingsAxonsNormal axonsDonor cellsNeuronal sourcesCord