2023
Repeated intravenous infusion of mesenchymal stem cells enhances recovery of motor function in a rat model with chronic spinal cord injury
Kurihara K, Sasaki M, Nagahama H, Obara H, Fukushi R, Hirota R, Yoshimoto M, Teramoto A, Kocsis J, Yamashita T, Honmou O. Repeated intravenous infusion of mesenchymal stem cells enhances recovery of motor function in a rat model with chronic spinal cord injury. Brain Research 2023, 1817: 148484. PMID: 37442249, DOI: 10.1016/j.brainres.2023.148484.Peer-Reviewed Original ResearchConceptsSpinal cord injuryInfusion of MSCsChronic spinal cord injuryMesenchymal stem cellsAxonal sproutingCord injuryHD-MSCsIntravenous infusionMotor functionVehicle groupWeek 6Single high-dose infusionInjection of MSCsChronic SCI ratsSingle MSC injectionGreater functional recoveryRat SCI modelSingle intravenous infusionHigh-dose infusionLimited treatment optionsGreater functional improvementSingle high doseHigh disease burdenVivo diffusion tensor imagingEx vivo diffusion tensor imaging
2022
Enhanced Network in Corticospinal Tracts after Infused Mesenchymal Stem Cells in Spinal Cord Injury
Hirota R, Sasaki M, Kataoka-Sasaki Y, Oshigiri T, Kurihara K, Fukushi R, Oka S, Ukai R, Yoshimoto M, Kocsis JD, Yamashita T, Honmou O. Enhanced Network in Corticospinal Tracts after Infused Mesenchymal Stem Cells in Spinal Cord Injury. Journal Of Neurotrauma 2022, 39: 1665-1677. PMID: 35611987, PMCID: PMC9734021, DOI: 10.1089/neu.2022.0106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsMammalsMesenchymal Stem CellsNerve RegenerationPyramidal TractsRecovery of FunctionSpinal CordSpinal Cord InjuriesConceptsSpinal cord injuryCorticospinal tractMesenchymal stem cellsCord injurySpinal cordSpontaneous recoveryInfused mesenchymal stem cellsLimited spontaneous recoveryDorsal corticospinal tractLateral corticospinal tractStem cellsCST pathwayCST projectionsSCI inductionMSC infusionAxonal sproutingFunctional recoveryLateral funiculusIntravenous infusionAxonal tracerLesion coreMotor pathwaysFunctional improvementCircuit reorganizationMajor projections
1992
A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons
Pongracz F, Poolos N, Kocsis J, Shepherd G. A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons. Journal Of Neurophysiology 1992, 68: 2248-2259. PMID: 1337105, PMCID: PMC2605954, DOI: 10.1152/jn.1992.68.6.2248.Peer-Reviewed Original ResearchConceptsReceptor-mediated conductanceExcitatory postsynaptic potentialsPyramidal neuronsSynaptic responsesSynaptic activationSize of EPSPsExtracellular ion concentration changesNMDA receptor-mediated activityCA1 hippocampal pyramidal cellsCA1 hippocampal pyramidal neuronsHippocampal CA1 pyramidal neuronsDendritic NMDA receptorsRepetitive synaptic activationCA1 pyramidal neuronsInhibitory synaptic responsesFrequency-dependent depressionHippocampal pyramidal neuronsNMDA receptor activationHippocampal pyramidal cellsExtracellular potassium accumulationRepetitive activityIntrinsic membrane conductancesReceptor-mediated activityHz. 4Spike afterdepolarization
1990
Dendritic action potentials activated by NMDA receptor-mediated EPSPs in CA1 hippocampal pyramidal cells
Poolos N, Kocsis J. Dendritic action potentials activated by NMDA receptor-mediated EPSPs in CA1 hippocampal pyramidal cells. Brain Research 1990, 524: 342-346. PMID: 1981329, DOI: 10.1016/0006-8993(90)90714-m.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsCA1 hippocampal pyramidal cellsDendritic action potentialsHippocampal pyramidal cellsPyramidal cellsRat CA1 hippocampal pyramidal cellsNMDA receptor-mediated excitatory postsynaptic potentialsAction potentialsDendritic excitatory postsynaptic potentialsN-methyl-D-aspartate receptorsPyramidal cell bodiesShort-term potentiationIntradendritic recordingsPostsynaptic potentialsSynaptic responsesDendritic arborsDendritic conductancesRepetitive stimulationDendritic spikesSomatic recordingsCell bodiesSubthreshold responsesMultiple sitesCellsRecordings