2023
Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy
Majd H, Amin S, Ghazizadeh Z, Cesiulis A, Arroyo E, Lankford K, Majd A, Farahvashi S, Chemel A, Okoye M, Scantlen M, Tchieu J, Calder E, Le Rouzic V, Shibata B, Arab A, Goodarzi H, Pasternak G, Kocsis J, Chen S, Studer L, Fattahi F. Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy. Cell Stem Cell 2023, 30: 632-647.e10. PMID: 37146583, PMCID: PMC10249419, DOI: 10.1016/j.stem.2023.04.006.Peer-Reviewed Original ResearchConceptsDiabetic peripheral neuropathySchwann cellsPeripheral neuropathyPeripheral nervous systemPrimary Schwann cellsBupropion treatmentDiabetic patientsMyelin damageSensory dysfunctionPrimary gliaSelective vulnerabilityAntidepressant drugsHyperglycemic miceLower incidenceRetrospective analysisHuman pluripotent stem cellsSC deathNervous systemTherapeutic candidateHigh glucoseNeuropathyHealth recordsMolecular featuresStem cellsPluripotent stem cells
2014
Transplantation of Schwann cells and olfactory ensheathing cells as a therapeutic strategy in spinal cord injury
Kocsis J, Bunge M. Transplantation of Schwann cells and olfactory ensheathing cells as a therapeutic strategy in spinal cord injury. 2014, 496-513. DOI: 10.1017/cbo9780511995583.036.Peer-Reviewed Original ResearchNervous systemNeural repairNormal central nervous systemSpinal cord damageSpinal cord injuryRecovery of functionCentral nervous systemNeuron replacementCerebral palsyCord damageCord injuryAxonal regenerationNeuronal deathSchwann cellsTherapeutic strategiesAxon regenerationNeurological rehabilitationBrain disordersCell therapyRehabilitation professionalsInjuryRepairRehabilitationBasic scienceStem cell biology
2008
18 MULTIPLE SCLEROSIS: REMYELINATION
KOCSIS J, SASAKI M, LANKFORD K, RADTKE C. 18 MULTIPLE SCLEROSIS: REMYELINATION. 2008, 413-435. DOI: 10.1016/b978-012373994-0.50020-8.Peer-Reviewed Original ResearchMyelin-forming cellsMultiple sclerosisConduction abnormalitiesPotential neuroprotective effectsProminent pathological featurePeripheral nervous systemEndogenous progenitor cellsPotassium channel distributionRemyelinated axonsIon channel organizationDemyelinated lesionsNeuroprotective effectsAxonal transectionPathological featuresFunctional deficitsMyelin repairAxonal repairMyelin resultsNervous systemImpulse conductionProgenitor cellsRemyelinationSclerosisTransectionAbnormalities
1995
Competition in the Synaptic Marketplace: Activity Is Important
Kocsis J. Competition in the Synaptic Marketplace: Activity Is Important. The Neuroscientist 1995, 1: 185-187. DOI: 10.1177/107385849500100401.Peer-Reviewed Original ResearchNervous systemMotor neuronsSynaptic connectionsMultiple motor neuronsMuscle fibersNerve impulse activityMature nervous systemRedundant synaptic connectionsAdult nervous systemMammalian nervous systemImpulse activityNeonatal miceSynaptic organizationMotor endplatesNeuronal plasticitySynaptic connectivityMultiple synapsesNeuromuscular junctionSynaptic interactionsNeuronsSynapsesMemory processesPrimary roleInnervationMiceModulation of axonal excitability by neurotransmitter receptors
KOCSIS J, SAKATANI K. Modulation of axonal excitability by neurotransmitter receptors. 1995, 281-295. DOI: 10.1093/acprof:oso/9780195082937.003.0014.Peer-Reviewed Original ResearchNeurotransmitter receptorsGABAA receptorsAxonal GABAA receptorsFunctional GABAA receptorsOptic nerve developmentOptic nerve axonsGABAA receptor activationPossible modulatory roleMammalian nervous systemAxonal excitabilityTrophic influenceNervous systemNerve developmentModulatory roleElectrophysiological propertiesReceptor activationImpulse conductionNerve axonsCertain axonsAxonal regionsReceptorsPossible functional significanceAxonsTransient presenceFunctional significance
1992
Transient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve
Sakatani K, Black J, Kocsis J. Transient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve. Proceedings Of The Royal Society B 1992, 247: 155-161. PMID: 1349183, DOI: 10.1098/rspb.1992.0022.Peer-Reviewed Original ResearchConceptsRat optic nerveOptic nerveCentral nervous systemGABAA receptorsIntact rat optic nerveCultured glia cellsFunctional GABAA receptorsGABAA receptor agonistNeonatal optic nerveNeuronal cell bodiesO-2A progenitor cellsNon-synaptic sitesPre-myelinated axonsWhite matter regionsSynthesis of GABAAxonal excitabilityReceptor agonistEndogenous GABAGABA uptakeGlia cellsSynaptic neurotransmittersNervous systemEndogenous neurotransmittersType 2Nerve
1990
Elevated extracellular potassium concentration enhances synaptic activation of N-methyl-d-aspartate receptors in hippocampus
Poolos N, Kocsis J. Elevated extracellular potassium concentration enhances synaptic activation of N-methyl-d-aspartate receptors in hippocampus. Brain Research 1990, 508: 7-12. PMID: 2159824, DOI: 10.1016/0006-8993(90)91110-3.Peer-Reviewed Original ResearchConceptsNMDA receptor activationNMDA receptorsReceptor activationNMDA receptor-mediated componentN-methyl-D-aspartate receptorsElevated extracellular potassium concentrationReceptor-mediated componentReceptor-mediated conductanceChannel blocker tetraethylammoniumCentral nervous systemExtracellular potassium concentrationExtracellular potassium ion concentrationSlowed repolarizationOrthodromic stimulationPotassium equilibrium potentialCA1 regionPyramidal cellsRat hippocampusSynaptic activationBlocker tetraethylammoniumPostsynaptic activityRepetitive stimulationNeuronal activityNervous systemReceptors
1985
Aminopyridine-sensitivity of spinal cord white matter studied in vitro
Kocsis J. Aminopyridine-sensitivity of spinal cord white matter studied in vitro. Experimental Brain Research 1985, 57: 620-624. PMID: 2984039, DOI: 10.1007/bf00237849.Peer-Reviewed Original ResearchConceptsCentral nervous system extensionSpinal cord white matterAction potential dischargeDorsal column axonsSucrose gap chamberCompound action potentialPeripheral nervous systemCord white matterVentral root fibersAction potential characteristicsSensory fibersDorsal columnsDorsal rootsSpinal cordNervous systemWhite matterAction potentialsPotential dischargeRoot fibersPotassium channelsCourse of maturationOcclusion experimentsAxonsPronounced increaseCord