Human mesenchymal stem‐derived extracellular vesicles improve body growth and motor function following severe spinal cord injury in rat
Nakazaki M, Lankford K, Yamamoto H, Mae Y, Kocsis J. Human mesenchymal stem‐derived extracellular vesicles improve body growth and motor function following severe spinal cord injury in rat. Clinical And Translational Medicine 2023, 13: e1284. PMID: 37323108, PMCID: PMC10272923, DOI: 10.1002/ctm2.1284.Peer-Reviewed Original ResearchConceptsSpinal cord injurySevere spinal cord injuryFunctional motor recoveryYoung adult ratsMotor recoveryMesenchymal stem/stromal cellsSmall extracellular vesiclesMSC-sEVsCord injuryM2 macrophagesMotor functionAdult ratsBody growthPro-inflammatory cytokine tumor necrosisAdult spinal cord injuryDay 7 post-SCISystemic pro-inflammatory cytokinesIGF-1 levelsPro-inflammatory cytokinesCytokine tumor necrosisSystemic serum levelsBroad therapeutic benefitsNormal body growthExtracellular vesiclesDifferent treatment groups