2024
A surgical protocol for establishing spinal cord ischemia with extended lifespan and low complication rates in rats
Yasuda N, Sasaki M, Kocsis J, Kawaharada N, Honmou O. A surgical protocol for establishing spinal cord ischemia with extended lifespan and low complication rates in rats. World Neurosurgery 2024, 188: e349-e356. PMID: 38789035, DOI: 10.1016/j.wneu.2024.05.114.Peer-Reviewed Original ResearchIschemic spinal cord injurySpinal cord ischemiaCord ischemiaComplication rateRat modelTherapeutic strategiesEvaluate new therapeutic strategiesFunctional recoveryMale Sprague-Dawley ratsLow complication rateSprague-Dawley ratsSpecialized surgical equipmentExperimental animal modelsImprove functional recoveryPromote functional recoverySpinal cord injuryCross-clampingSevere neurological disordersAzygos veinSurgical protocolDescending aortaBulldog clampsLumbar levelsSpinal cordIschemic lesions
2022
Enhanced Network in Corticospinal Tracts after Infused Mesenchymal Stem Cells in Spinal Cord Injury
Hirota R, Sasaki M, Kataoka-Sasaki Y, Oshigiri T, Kurihara K, Fukushi R, Oka S, Ukai R, Yoshimoto M, Kocsis JD, Yamashita T, Honmou O. Enhanced Network in Corticospinal Tracts after Infused Mesenchymal Stem Cells in Spinal Cord Injury. Journal Of Neurotrauma 2022, 39: 1665-1677. PMID: 35611987, PMCID: PMC9734021, DOI: 10.1089/neu.2022.0106.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCorticospinal tractMesenchymal stem cellsCord injurySpinal cordSpontaneous recoveryInfused mesenchymal stem cellsLimited spontaneous recoveryDorsal corticospinal tractLateral corticospinal tractStem cellsCST pathwayCST projectionsSCI inductionMSC infusionAxonal sproutingFunctional recoveryLateral funiculusIntravenous infusionAxonal tracerLesion coreMotor pathwaysFunctional improvementCircuit reorganizationMajor projections
2013
Sciatic nerve regeneration is not inhibited by anti-NGF antibody treatment in the adult rat
Lankford K, Arroyo E, Liu C, Somps C, Zorbas M, Shelton D, Evans M, Hurst S, Kocsis J. Sciatic nerve regeneration is not inhibited by anti-NGF antibody treatment in the adult rat. Neuroscience 2013, 241: 157-169. PMID: 23531437, DOI: 10.1016/j.neuroscience.2013.03.024.Peer-Reviewed Original ResearchConceptsNerve growth factorAdult ratsNerve regenerationFunctional recoveryAnti-NGF antibody treatmentElevated nerve growth factorUnilateral sciatic nerve crushDorsal root ganglion neuronsAnti-NGF antibodySciatic nerve crushType of painVehicle-treated animalsSciatic nerve regenerationPost nerve injuryNovel therapeutic approachesCell body sizePeripheral nerve regenerationFluro-GoldPeripheral nervous system developmentNerve injuryPain modelNerve crushPain managementAntibody treatmentGait recovery
2005
28 Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons
Kocsis J, Sasaki M. 28 Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons. 2005, 421-433. DOI: 10.1016/b978-012738761-1/50029-8.Peer-Reviewed Original ResearchTransplantation of SCsTransplantation of OECsSpinal cord injuryCentral nervous systemSchwann cellsAxonal regenerationBone marrow cellsFunctional recoveryMultiple sclerosisCell transplantationCord injurySpinal cordHind limb locomotor functionContusive spinal cord injuryBone marrow cell transplantationMarrow cellsSpinal cord injury modelMarrow cell transplantationCerebral ischemia modelSpinal cord resultsGlobal neuroprotectionDemyelination modelCord resultsFunctional outcomeDemyelinated axons
1997
Spinal Cord Repair: Progress Towards a Daunting Goal
Waxman S, Kocsis J. Spinal Cord Repair: Progress Towards a Daunting Goal. The Neuroscientist 1997, 3: 263-269. DOI: 10.1177/107385849700300414.Peer-Reviewed Original ResearchSpinal cord repairSpinal cordHuman spinal cord injuryUse of neurotrophinsSpinal cord injuryMyelin-forming glial cellsSpinal cord tractsFunctional recoveryNerve graftsAnatomical repairCord injuryGlial cellsAnimal modelsWhite matterGray matterClinical goalsCordInjuryPartial restorationRepairDaunting goalTransplantationNeurotrophinsGraftCNS
1983
Long-term regenerated nerve fibres retain sensitivity to potassium channel blocking agents
Kocsis J, Waxman S. Long-term regenerated nerve fibres retain sensitivity to potassium channel blocking agents. Nature 1983, 304: 640-642. PMID: 6308475, DOI: 10.1038/304640a0.Peer-Reviewed Original ResearchConceptsNerve fibersPotassium channelsMyelinated peripheral nerve fibresAxon segmentsPeripheral nerve fibersAxon sproutsEndoneurial tubesNerve crushFunctional recoveryFunctional organizationMyelinated fibersAxon cylindersSchwann cellsBurst activityMyelinated axonsMammalian axonsAxonsPeripheral connectionsMembrane depolarizationBasement membraneK channelsRegenerated fibersAxon maturation