Hui Jing Lim, PhD
Postdoctoral AssociateAbout
Research
Publications
2022
A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells.
Lim HJ, Wubben JM, Garcia CP, Cruz-Gomez S, Deng J, Mak JYW, Hachani A, Anderson RJ, Painter GF, Goyette J, Amarasinghe SL, Ritchie ME, Roquilly A, Fairlie DP, Gaus K, Rossjohn J, Villadangos JA, McWilliam HEG. A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells. The Journal Of Cell Biology 2022, 221 PMID: 36129434, DOI: 10.1083/jcb.202110125.Peer-Reviewed Original ResearchUbiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86.
Liu H, Wilson KR, Firth AM, Macri C, Schriek P, Blum AB, Villar J, Wormald S, Shambrook M, Xu B, Lim HJ, McWilliam HEG, Hill AF, Edgington-Mitchell LE, Caminschi I, Lahoud MH, Segura E, Herold MJ, Villadangos JA, Mintern JD. Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86. Nature Communications 2022, 13: 1934. PMID: 35411049, PMCID: PMC9001657, DOI: 10.1038/s41467-022-29524-w.Peer-Reviewed Original Research
2020
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens.
McWilliam HEG, Mak JYW, Awad W, Zorkau M, Cruz-Gomez S, Lim HJ, Yan Y, Wormald S, Dagley LF, Eckle SBG, Corbett AJ, Liu H, Li S, Reddiex SJJ, Mintern JD, Liu L, McCluskey J, Rossjohn J, Fairlie DP, Villadangos JA. Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 24974-24985. PMID: 32958637, PMCID: PMC7547156, DOI: 10.1073/pnas.2011260117.Peer-Reviewed Original ResearchAbsence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1.
Howson LJ, Awad W, von Borstel A, Lim HJ, McWilliam HEG, Sandoval-Romero ML, Majumdar S, Hamzeh AR, Andrews TD, McDermott DH, Murphy PM, Le Nours J, Mak JYW, Liu L, Fairlie DP, McCluskey J, Villadangos JA, Cook MC, Turner SJ, Davey MS, Ojaimi S, Rossjohn J. Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1. Science Immunology 2020, 5 PMID: 32709702, PMCID: PMC8581949, DOI: 10.1126/sciimmunol.abc9492.Peer-Reviewed Original Research
2016
Temporal proteomic profiling of Chlamydia trachomatis-infected HeLa-229 human cervical epithelial cells.
Tan GM, Lim HJ, Yeow TC, Movahed E, Looi CY, Gupta R, Arulanandam BP, Abu Bakar S, Sabet NS, Chang LY, Wong WF. Temporal proteomic profiling of Chlamydia trachomatis-infected HeLa-229 human cervical epithelial cells. Proteomics 2016, 16: 1347-60. PMID: 27134121, DOI: 10.1002/pmic.201500219.Peer-Reviewed Original Research