David R. Martinez, PhD
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Assistant Professor
Biography
David R. Martinez, Ph.D. studies immunity to viral pathogens of global health importance. David grew up in El Salvador until age 13. As a young child, David became interested in emerging viruses because of innate curiosity in viruses and vaccines as well as his exposure to public health campaigns to fight arthropod-borne viruses (e.g., Dengue virus) and other infectious diseases. David received his Ph.D. from Duke University and trained with leading vaccine immunologist, Dr. Sallie R. Permar, at the Duke Human Vaccine Institute. Following the completion of his doctoral studies, David trained as a postdoctoral scholar with one of the world’s leading coronavirologists, Dr. Ralph Baric, at UNC Chapel Hill before and during the COVID-19 pandemic studying immunity to flaviviruses and coronaviruses. Dr. Martinez was part of the teams that contributed to the development of the FDA-approved and widely used Moderna COVID-19 vaccine and the Johnson & Johnson COVID-19 vaccine which was used under Emergency Use Authorization. Dr. Martinez also contributed to the pre-clinical development of COVID-19 human monoclonal antibody therapies from Eli Lilly and AstraZeneca which also received FDA Emergency Use Authorization. Dr. Martinez is a Hanna H. Gray Faculty Fellow of the Howard Hughes Medical Institute.
Appointments
Immunobiology
Assistant ProfessorPrimary
Other Departments & Organizations
- Center for Infection and Immunity
- Human and Translational Immunology Program
- Immunobiology
- Immunology
- Janeway Society
- Microbiology
- Virology Laboratories
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- Postdoctoral Scholar
- University of North Carolina at Chapel Hill (2023)
- PhD
- Duke University, Molecular Genetics and Microbiology (2018)
- BS
- University of Oklahoma, Microbiology (2013)
Research
Overview
Medical Research Interests
Public Health Interests
The Martinez laboratory
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Research at a Glance
Publications Timeline
Publications
Featured Publications
Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice.
Martinez DR, Schäfer A, Leist SR, De la Cruz G, West A, Atochina-Vasserman EN, Lindesmith LC, Pardi N, Parks R, Barr M, Li D, Yount B, Saunders KO, Weissman D, Haynes BF, Montgomery SA, Baric RS. Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice. Science 2021, 373: 991-998. PMID: 34214046, DOI: 10.1126/science.abi4506.Peer-Reviewed Original ResearchFc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women.
Martinez DR, Fong Y, Li SH, Yang F, Jennewein MF, Weiner JA, Harrell EA, Mangold JF, Goswami R, Seage GR 3rd, Alter G, Ackerman ME, Peng X, Fouda GG, Permar SR. Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women. Cell 2019, 178: 190-201.e11. PMID: 31204101, DOI: 10.1016/j.cell.2019.05.046.Peer-Reviewed Original Research
2024
The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.
Martinez DR, Moreira FR, Catanzaro NJ, Diefenbacher MV, Zweigart MR, Gully KL, De la Cruz G, Brown AJ, Adams LE, Yount B, Baric TJ, Mallory ML, Conrad H, May SR, Dong S, Scobey DT, Nguyen C, Montgomery SA, Perry JK, Babusis D, Barrett KT, Nguyen AH, Nguyen AQ, Kalla R, Bannister R, Feng JY, Cihlar T, Baric RS, Mackman RL, Bilello JP, Schäfer A, Sheahan TP. The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses. Sci Transl Med 2024, 16: eadj4504. PMID: 38776389, DOI: 10.1126/scitranslmed.adj4504.Peer-Reviewed Original Research
2023
Vaccine-mediated protection against Merbecovirus and Sarbecovirus challenge in mice.
Martinez DR, Schäfer A, Gavitt TD, Mallory ML, Lee E, Catanzaro NJ, Chen H, Gully K, Scobey T, Korategere P, Brown A, Smith L, Parks R, Barr M, Newman A, Bowman C, Powers JM, Soderblom EJ, Mansouri K, Edwards RJ, Baric RS, Haynes BF, Saunders KO. Vaccine-mediated protection against Merbecovirus and Sarbecovirus challenge in mice. Cell Rep 2023, 113248. PMID: 37858337, DOI: 10.1016/j.celrep.2023.113248.Peer-Reviewed Original Research
2022
Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine.
Li D, Martinez DR, Schäfer A, Chen H, Barr M, Sutherland LL, Lee E, Parks R, Mielke D, Edwards W, Newman A, Bock KW, Minai M, Nagata BM, Gagne M, Douek DC, DeMarco CT, Denny TN, Oguin TH 3rd, Brown A, Rountree W, Wang Y, Mansouri K, Edwards RJ, Ferrari G, Sempowski GD, Eaton A, Tang J, Cain DW, Santra S, Pardi N, Weissman D, Tomai MA, Fox CB, Moore IN, Andersen H, Lewis MG, Golding H, Seder R, Khurana S, Baric RS, Montefiori DC, Saunders KO, Haynes BF. Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine. Nat Commun 2022, 13: 6309. PMID: 36274085, DOI: 10.1038/s41467-022-33985-4.Peer-Reviewed Original ResearchTherapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice.
Schäfer A, Martinez DR, Won JJ, Meganck RM, Moreira FR, Brown AJ, Gully KL, Zweigart MR, Conrad WS, May SR, Dong S, Kalla R, Chun K, Du Pont V, Babusis D, Tang J, Murakami E, Subramanian R, Barrett KT, Bleier BJ, Bannister R, Feng JY, Bilello JP, Cihlar T, Mackman RL, Montgomery SA, Baric RS, Sheahan TP. Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice. Sci Transl Med 2022, 14: eabm3410. PMID: 35315683, DOI: 10.1126/scitranslmed.abm3410.Peer-Reviewed Original ResearchA broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice.
Martinez DR, Schäfer A, Gobeil S, Li D, De la Cruz G, Parks R, Lu X, Barr M, Stalls V, Janowska K, Beaudoin E, Manne K, Mansouri K, Edwards RJ, Cronin K, Yount B, Anasti K, Montgomery SA, Tang J, Golding H, Shen S, Zhou T, Kwong PD, Graham BS, Mascola JR, Montefiori DC, Alam SM, Sempowski G, Sempowski GD, Khurana S, Wiehe K, Saunders KO, Acharya P, Haynes BF, Baric RS. A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice. Sci Transl Med 2022, 14: eabj7125. PMID: 34726473, DOI: 10.1126/scitranslmed.abj7125.Peer-Reviewed Original Research
2021
Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines.
Collier AY, Yu J, McMahan K, Liu J, Chandrashekar A, Maron JS, Atyeo C, Martinez DR, Ansel JL, Aguayo R, Rowe M, Jacob-Dolan C, Sellers D, Barrett J, Ahmad K, Anioke T, VanWyk H, Gardner S, Powers O, Bondzie EA, Wan H, Baric RS, Alter G, Hacker MR, Barouch DH. Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines. N Engl J Med 2021, 385: 2010-2012. PMID: 34648703, DOI: 10.1056/NEJMc2115596.Peer-Reviewed Original ResearchIn vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.
Li D, Edwards RJ, Manne K, Martinez DR, Schäfer A, Alam SM, Wiehe K, Lu X, Parks R, Sutherland LL, Oguin TH 3rd, McDanal C, Perez LG, Mansouri K, Gobeil SMC, Janowska K, Stalls V, Kopp M, Cai F, Lee E, Foulger A, Hernandez GE, Sanzone A, Tilahun K, Jiang C, Tse LV, Bock KW, Minai M, Nagata BM, Cronin K, Gee-Lai V, Deyton M, Barr M, Von Holle T, Macintyre AN, Stover E, Feldman J, Hauser BM, Caradonna TM, Scobey TD, Rountree W, Wang Y, Moody MA, Cain DW, DeMarco CT, Denny TN, Woods CW, Petzold EW, Schmidt AG, Teng IT, Zhou T, Kwong PD, Mascola JR, Graham BS, Moore IN, Seder R, Andersen H, Lewis MG, Montefiori DC, Sempowski GD, Baric RS, Acharya P, Haynes BF, Saunders KO. In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies. Cell 2021, 184: 4203-4219.e32. PMID: 34242577, DOI: 10.1016/j.cell.2021.06.021.Peer-Reviewed Original ResearchImmunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans.
Alter G, Yu J, Liu J, Chandrashekar A, Borducchi EN, Tostanoski LH, McMahan K, Jacob-Dolan C, Martinez DR, Chang A, Anioke T, Lifton M, Nkolola J, Stephenson KE, Atyeo C, Shin S, Fields P, Kaplan I, Robins H, Amanat F, Krammer F, Baric RS, Le Gars M, Sadoff J, de Groot AM, Heerwegh D, Struyf F, Douoguih M, van Hoof J, Schuitemaker H, Barouch DH. Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans. Nature 2021, 596: 268-272. PMID: 34107529, DOI: 10.1038/s41586-021-03681-2.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
honor Early Career Researcher Award
National AwardElsevier VaccineDetails07/01/2024Portugalhonor AAI Aspire Award
National AwardAmerican Association of ImmunologistsDetails01/18/2024United Stateshonor Rising Stars Mentorship Program Awardee
National AwardGlobal Virus NetworkDetails11/01/2022United Stateshonor Dr. Eddie Mendez Award
National AwardFred Hutchinson Cancer CenterDetails06/09/2022United Stateshonor Hanna H. Gray Fellowship
National AwardHoward Hughes Medical InstituteDetails12/18/2020United States
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