2024
Developing expert consensus for the use of hedgehog inhibitors in basal cell nevus syndrome
Lukowiak T, Cahn B, Samie F, Leffell D, Oro A, Kibbi N, Kheterpal M, Babakoohi S, Khushalani N, Stephenson A, Ma M, Shi V, Ahmed A, Koza E, Haq M, Yi M, Nadir U, Yoo S, Brieva J, Lucas J, Haber R, Alam M. Developing expert consensus for the use of hedgehog inhibitors in basal cell nevus syndrome. Archives Of Dermatological Research 2024, 316: 453. PMID: 38967654, DOI: 10.1007/s00403-024-03157-z.Peer-Reviewed Original Research
2022
Artificial intelligence in the detection of skin cancer
Beltrami E, Brown A, Salmon P, Leffell D, Ko J, Grant-Kels J. Artificial intelligence in the detection of skin cancer. Journal Of The American Academy Of Dermatology 2022, 87: 1336-1342. PMID: 35998842, DOI: 10.1016/j.jaad.2022.08.028.Peer-Reviewed Original ResearchConceptsArtificial intelligenceReduce health care costsSkin cancerHealth care costsImprove quality of lifeReducing physician concernsLimitations of AIQuality of lifeReducing unnecessary proceduresManagement of skin cancerDetection of skin cancerAI capabilitiesSkin cancer detectionPatient careSkin assessmentCare costsPhysician concernsAI technologyImprove qualityPromote greater accessUnnecessary proceduresClinical settingFundamental terminologyCancerCancer detection
2020
Predicting outcomes following second intent healing of periocular surgical defects
Kibbi N, Khan Y, Leffell DJ, Christensen SR, Suozzi KC. Predicting outcomes following second intent healing of periocular surgical defects. Archives Of Dermatological Research 2020, 313: 483-489. PMID: 32833078, DOI: 10.1007/s00403-020-02122-w.Peer-Reviewed Original ResearchConceptsMohs micrographic surgeryMedial canthusSingle academic surgical centerAcademic surgical centerConclusionsThis retrospective studyMedial canthal lesionAverage defect diameterMethodsRetrospective analysisTumor characteristicsPeriocular tumorsRetrospective studyPoor outcomePeriocular lesionsSurgical centersMicrographic surgeryWorse outcomesAnatomic locationAimThe purposeScar outcomeLarge lesionsUpper eyelidEyelid marginLid marginSurgical defectsLower eyelidMelanoma in situ: Don't make the cure worse than the disease
Prassinos A, Glusac E, Leffell DJ. Melanoma in situ: Don't make the cure worse than the disease. Journal Of The American Academy Of Dermatology 2020, 85: 520. PMID: 32387662, DOI: 10.1016/j.jaad.2020.04.168.Peer-Reviewed Original Research
2019
Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness
Kibbi N, Zhang Y, Leffell DJ, Christensen SR. Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness. Journal Of The American Academy Of Dermatology 2019, 82: 1124-1130. PMID: 31712171, DOI: 10.1016/j.jaad.2019.10.079.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAminolevulinic AcidAnalysis of VarianceBiopsy, NeedleCarcinoma in SituCarcinoma, Squamous CellCohort StudiesDisease-Free SurvivalFemaleHumansImmunohistochemistryLogistic ModelsMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingPhotochemotherapyPrognosisRetrospective StudiesSkin NeoplasmsSurvival AnalysisTreatment OutcomeTumor BurdenConceptsCutaneous squamous cell carcinomaALA incubation timeSquamous cell carcinomaTumor diameterALA-PDTSubsequent recurrenceCell carcinomaAnatomic locationInitial complete response ratePhotodynamic therapyCases of SCCISMultivariate analysis factorsComplete response rateMedical record reviewEffectiveness of PDTPatient demographicsClinical responseMedian timeRetrospective reviewRecord reviewRetrospective studyTreatment detailsSingle institutionEffective treatmentResponse rateOptical Spectroscopy as a Method for Skin Cancer Risk Assessment
Rodriguez‐Diaz E, Manolakos D, Christman H, Bonning MA, Geisse JK, A'Amar OM, Leffell DJ, Bigio IJ. Optical Spectroscopy as a Method for Skin Cancer Risk Assessment. Photochemistry And Photobiology 2019, 95: 1441-1445. PMID: 31287160, DOI: 10.1111/php.13140.Peer-Reviewed Original ResearchSquamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease
Kibbi N, Suozzi KC, Ko CJ, Leffell DJ. Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease. Dermatologic Surgery 2019, Publish Ahead of Print: &na;. PMID: 31260417, DOI: 10.1097/dss.0000000000001706.Peer-Reviewed Original Research
2018
Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma
Totonchy MB, Leventhal JS, Ko CJ, Leffell DJ. Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma. Dermatologic Surgery 2018, 44: 1466-1470. PMID: 29360655, DOI: 10.1097/dss.0000000000001465.Peer-Reviewed Original ResearchCutaneous immunohistochemical staining pattern of p53β isoforms
Ko CJ, Myung P, Leffell DJ, Bourdon JC. Cutaneous immunohistochemical staining pattern of p53β isoforms. Journal Of Clinical Pathology 2018, 71: 1120. PMID: 30305316, DOI: 10.1136/jclinpath-2018-205098.Peer-Reviewed Original ResearchConceptsSquamous tumorsMarkers of differentiationSquamous proliferationIsoforms of p53Mutational statusHair folliclesP53 pathwayDomain mutationsExact biological significanceP53Differentiated layersSkinP53 isoformsSuch mutationsIsoformsDifferent isoformsNumerous functionsTumorsCancerMutationsFolliclesBiological significanceTransparency and Dermatologic Device Approval by the US Food and Drug Administration
Ezaldein HH, Scott JF, Yin ES, Ventura A, DeRuyter NP, Leffell DJ. Transparency and Dermatologic Device Approval by the US Food and Drug Administration. JAMA Dermatology 2018, 154: 273-280. PMID: 29365020, PMCID: PMC5885836, DOI: 10.1001/jamadermatol.2017.5757.Peer-Reviewed Original Research
2017
Cross-sectional assessment of ultraviolet radiation–related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma
Ferrucci LM, Cartmel B, Clare RA, Choy CC, Kershaw T, Leffell DJ, Mayne ST. Cross-sectional assessment of ultraviolet radiation–related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma. Journal Of The American Academy Of Dermatology 2017, 79: 149-152. PMID: 29291957, PMCID: PMC6004335, DOI: 10.1016/j.jaad.2017.12.056.Peer-Reviewed Original ResearchSquamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases
Ko CJ, Glusac EJ, McNiff JM, Rodic N, Leffell DJ. Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases. Journal Of The American Academy Of Dermatology 2017, 77: 1126-1132.e1. PMID: 28709693, DOI: 10.1016/j.jaad.2017.04.1119.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaProminent cytologic atypiaMultiple squamous cell carcinomasCytologic atypiaSquamous proliferationTP53 mutationsDetectable TP53 mutationsLegs of womenFollicle-like structuresCell carcinomaHistopathologic findingsMultiple lesionsSCC lesionsHistopathologic analysisTP53 sequencingNumerous tumorsSmall seriesTP53 variantsClinical phenotypeKeratoacanthomaLesionsTumorsDifferent patientsAtypiaReactive phenomenonWell‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63
Panse G, Cowper SE, Leffell DJ, Pulitzer M, Ko CJ. Well‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63. Journal Of Cutaneous Pathology 2017, 44: 557-562. PMID: 28417484, DOI: 10.1111/cup.12952.Peer-Reviewed Original ResearchConceptsCutaneous adnexal neoplasmsAdnexal neoplasmsNeuroendocrine tumorsAdnexal tumorsBenign skin adnexal tumorCutaneous adnexal tumorsAggressive metastatic diseaseLow-grade tumorsSkin adnexal tumorsMajority of casesMetastatic diseaseMetastatic adenocarcinomaCarcinoid tumorsCytokeratin 5/6Diagnostic challengeDifferential diagnosisImmunohistochemical stainsCK5/6Diagnostic utilityPrimary siteTumorsNeoplasmsFirst signWDNETsP63Predictors of tanning dependence in white non‐Hispanic females and males
Cartmel B, Bale AE, Mayne ST, Gelernter JE, DeWan AT, Spain P, Leffell DJ, Pagoto S, Ferrucci LM. Predictors of tanning dependence in white non‐Hispanic females and males. Journal Of The European Academy Of Dermatology And Venereology 2017, 31: 1223-1228. PMID: 28129487, PMCID: PMC5522341, DOI: 10.1111/jdv.14138.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaCase-control studyBasal cell carcinomaWhite non-Hispanic femalesSymptoms of dependenceCell carcinomaNon-Hispanic femalesAlcohol dependenceMental disordersAppropriate interventionsHost factorsNon-HispanicsStatistical ManualMultivariate modelIndoor tanningSignificant predictorsOnline surveyFourth EditionPredictorsEuropean ancestryQuestionnaireEye openerEye colorParticipantsCarcinoma
2016
Body mass index, height and early-onset basal cell carcinoma in a case-control study
Zhang Y, Cartmel B, Choy CC, Molinaro AM, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Body mass index, height and early-onset basal cell carcinoma in a case-control study. Cancer Epidemiology 2016, 46: 66-72. PMID: 28039770, PMCID: PMC5272867, DOI: 10.1016/j.canep.2016.12.007.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaBody mass indexBasal cell carcinomaMass indexCell carcinomaInverse associationOdds ratioAdult heightUnconditional logistic regression modelsAdult body mass indexBenign skin conditionsMultivariate odds ratiosSimilar inverse associationsConfidence intervalsCase-control studySignificant inverse associationLogistic regression modelsUltraviolet radiation exposurePrior UV exposureCommon malignancyControl subjectsUV exposureBiopsy siteMedical characteristicsSkin conditionsHistopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity
Munday WR, Leffell DJ, McNiff JM, Ko CJ. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity. Journal Of Cutaneous Pathology 2016, 43: 759-765. PMID: 27220356, DOI: 10.1111/cup.12738.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaMultiple squamous cell carcinomasCutaneous squamous cell carcinomaHistopathologic featuresCell carcinomaLower extremitiesMultiple cutaneous squamous cell carcinomasRetrospective chart reviewAmerican Joint CommitteeCancer staging criteriaDistinct clinical subtypesChart reviewPerineural invasionActinic keratosisStaging criteriaClinical subtypesMost lesionsStage IJoint CommitteeStage IIKeratoacanthomaPatientsCarcinomaTumorsSubtypes
2015
Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach
Christensen SR, McNiff JM, Cool AJ, Aasi SZ, Hanlon AM, Leffell DJ. Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach. Journal Of The American Academy Of Dermatology 2015, 74: 356-362. PMID: 26670714, DOI: 10.1016/j.jaad.2015.09.060.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaHair follicle infundibulumFollicular invasionCell carcinomaMohs micrographic surgeryHair follicle epitheliumAdditional patientsIntraoperative pathologyOptimal therapyRetrospective reviewTreatment failureProspective evaluationSingle institutionHistopathologic assessmentMicrographic surgeryMost tumorsDeep invasionTreatment approachesPathology specimensFollicle epitheliumLower follicleSCCISSurgeryCarcinomaInvasionRandomized comparison of the safety of Flublok® versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥50 years of age
Izikson R, Leffell DJ, Bock SA, Patriarca PA, Post P, Dunkle LM, Cox MM. Randomized comparison of the safety of Flublok® versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥50 years of age. Vaccine 2015, 33: 6622-6628. PMID: 26529070, DOI: 10.1016/j.vaccine.2015.10.097.Peer-Reviewed Original ResearchConceptsYears of ageVaccine groupInfluenza vaccineHypersensitivity reactionsPossible hypersensitivityOverall adverse event profileUnsolicited adverse eventsInactivated influenza vaccineAdverse event profileSeasonal influenza vaccineIncidence of hypersensitivityAdverse event termsAdverse eventsRandomized comparisonEvent profileClinical criteriaClinical trialsStable adultsAfluriaCase recordsHealthy adultsTreatment assignmentHypersensitivityVaccineFlublokFamily history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype
Berlin NL, Cartmel B, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype. Cancer Epidemiology 2015, 39: 1078-1083. PMID: 26381319, PMCID: PMC4679454, DOI: 10.1016/j.canep.2015.09.005.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaBasal cell carcinomaFamily historySkin cancerAge of onsetLifestyle factorsBenign skin conditionsStrong risk factorFirst-degree relativesMC1R genotypeCell carcinomaRisk factorsAge 40High riskLifestyle characteristicsAge 50Particular malignancySkin conditionsBCC casesCancerGenetic susceptibilitySaliva samplesMultivariate modelIndividual riskAffected relativesMelanoma in situ Part I. Epidemiology, screening, and clinical features
Higgins HW, Lee KC, Galan A, Leffell DJ. Melanoma in situ Part I. Epidemiology, screening, and clinical features. Journal Of The American Academy Of Dermatology 2015, 73: 181-190. PMID: 26183967, DOI: 10.1016/j.jaad.2015.04.014.Peer-Reviewed Original ResearchConceptsClinical featuresPart I. EpidemiologyReview of melanomaUnderstanding of melanomaIncidence of melanomaMedical education articleI. EpidemiologyClinical outcomesTreatment optionsClinical managementRisk factorsMalignant melanomaBiologic behaviorClinical studiesMelanomaEpidemiologyIncidenceHigh percentageEducation articlesHistopathologyPathology