David J Leffell, MD, MDCM
David P. Smith Professor Emeritus of DermatologyCards
About
Titles
David P. Smith Professor Emeritus of Dermatology
Section Chief, Dermatologic Surgery and Cutaneous Oncology
Biography
A graduate of Yale College and the McGill University Faculty of Medicine in Montreal, Leffell completed his residency training in internal medicine at Cornell Cooperating Hospitals and then in dermatology at Yale-New Haven Hospital. He completed an NIH post-doctoral research fellowship in dermatology at Yale followed by a clinical fellowship in dermatologic surgery at the University of Michigan Medical School in Ann Arbor. Author of the popular book "Total Skin," Leffell is an expert clinician, specializing in skin cancer and melanoma diagnosis and surgical treatment using the Mohs micrographic technique. The Cutaneous Oncology Unit that he founded in 1988 now performs specialized surgical treatment on more than 3,500 patients annually. His major clinical interest is the management of skin cancer, including basal cell cancer, squamous cell cancer and melanoma. In 1996 Leffell was a member of the research group that discovered the skin cancer gene known as PTCH. In addition, he has conducted collaborative research clarifying the role of ultraviolet radiation in skin cancer and skin aging. Author of more than 200 publications, Leffell has also done research on epidemiologic aspects of skin cancer and wound healing. Dr. Leffell was the first CEO of the Yale Medical Group (now Yale Medicine) and served as Deputy Dean for Clinical Affairs at Yale for almost a decade.
Appointments
Dermatology
EmeritusPrimaryDermatology
Senior Research ScientistSecondary
Other Departments & Organizations
- Cutaneous Oncology Program
- Dermatologic Laser Surgery Program
- Dermatologic Surgery
- Dermatology
- Genomics, Genetics, and Epigenetics
- Head and Neck Cancers Program
- Mohs Surgery
- Skin & Kidney Cancer Program
- Yale Cancer Center
- Yale New Haven Health System
Education & Training
- Fellow
- University of Michigan Medical School, Ann Arbor, MI (1988)
- N.I.H Postdoctoral Fellow
- Yale University School of Medicine, New Haven, CT (1987)
- Resident
- Yale-New Haven Hospital, New Haven, CT (1986)
- Resident
- Cornell Cooperating Hospitals (1984)
- Intern
- Cornell Cooperating Hospitals (1982)
- MDCM
- McGill University (1981)
- BS
- Yale College, Biology (1977)
Board Certifications
Micrographic Dermatologic Surgery
- Certification Organization
- American College of MOHS Surgery
- Original Certification Date
- 1988
Dermatology
- Certification Organization
- AB of Dermatology
- Latest Certification Date
- 2009
- Original Certification Date
- 1987
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1984
Research
Overview
When I founded the Dermatologic Surgery program at Yale in 1988, my goal was to combine state of the art patient care with clinical research. We often talk about bench to bedside as the framework for discovery in medicine but in fact most innovations related to disease proceed the other way: from bedside to bench. A doctor recognizes a pattern in a particular disease or makes a novel observation in a patient and that raises questions for investigation in the laboratory. Early in my career I observed an increase in basal cell cancer in young women. This was unusual for a disease typically noted in older men. Investigation into sun practices and related issues became the basis for a component of a SPORE grant that the department was awarded. Because we treat a very large number of skin cancers and melanoma and perform reconstructive surgery, a large focus of our research has also been on wound healing. We have published on the use of artificial skin substitutes to facilitate healing and I am involved with a commercial entity with a connexin43 molecule currently in clinical trials. In a broad sense my research collaborations extend from skin cancer in the immune compromised, to the biology of skin cancer in general and its epidemiology to the development of innovative treatments.
Medical Research Interests
Academic Achievements & Community Involvement
News & Links
News
- October 23, 2024
Four Faculty Members Honored for Clinical Excellence
- May 05, 2023
Yale Dermatologists Named Connecticut’s ‘Top Doctors’
- May 01, 2023
Connecticut Magazine’s 2023 “Top Doctors” issue recognizes 81 Smilow Cancer Hospital and Yale Cancer Center physicians
- January 11, 2023Source: WTNH News8
Yale expert familiar with procedure used on First Lady Jill Biden’s skin cancer
Get In Touch
Contacts
Dermatology
40 Temple Street,
New Haven, CT 06510
United States
Administrative Support
Locations
Yale Dermatologic Surgery
Academic Office
Temple Medical Center
40 Temple Street, Ste 5A
New Haven, CT 06510