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David J Leffell, MD, MDCM

David P. Smith Professor Emeritus of Dermatology
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Additional Titles

Section Chief, Dermatologic Surgery and Cutaneous Oncology

Contact Info

Dermatology

40 Temple Street,

New Haven, CT 06510

United States

About

Titles

David P. Smith Professor Emeritus of Dermatology

Section Chief, Dermatologic Surgery and Cutaneous Oncology

Biography

A graduate of Yale College and the McGill University Faculty of Medicine in Montreal, Leffell completed his residency training in internal medicine at Cornell Cooperating Hospitals and then in dermatology at Yale-New Haven Hospital. He completed an NIH post-doctoral research fellowship in dermatology at Yale followed by a clinical fellowship in dermatologic surgery at the University of Michigan Medical School in Ann Arbor. Author of the popular book "Total Skin," Leffell is an expert clinician, specializing in skin cancer and melanoma diagnosis and surgical treatment using the Mohs micrographic technique. The Cutaneous Oncology Unit that he founded in 1988 now performs specialized surgical treatment on more than 3,500 patients annually. His major clinical interest is the management of skin cancer, including basal cell cancer, squamous cell cancer and melanoma. In 1996 Leffell was a member of the research group that discovered the skin cancer gene known as PTCH. In addition, he has conducted collaborative research clarifying the role of ultraviolet radiation in skin cancer and skin aging. Author of more than 200 publications, Leffell has also done research on epidemiologic aspects of skin cancer and wound healing. Dr. Leffell was the first CEO of the Yale Medical Group (now Yale Medicine) and served as Deputy Dean for Clinical Affairs at Yale for almost a decade.

Last Updated on November 18, 2022.

Appointments

Other Departments & Organizations

Education & Training

Fellow
University of Michigan Medical School, Ann Arbor, MI (1988)
N.I.H Postdoctoral Fellow
Yale University School of Medicine, New Haven, CT (1987)
Resident
Yale-New Haven Hospital, New Haven, CT (1986)
Resident
Cornell Cooperating Hospitals (1984)
Intern
Cornell Cooperating Hospitals (1982)
MDCM
McGill University (1981)
BS
Yale College, Biology (1977)

Board Certifications

  • Micrographic Dermatologic Surgery

    Certification Organization
    American College of MOHS Surgery
    Original Certification Date
    1988
  • Dermatology

    Certification Organization
    AB of Dermatology
    Latest Certification Date
    2009
    Original Certification Date
    1987
  • Internal Medicine

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    1984

Research

Overview

When I founded the Dermatologic Surgery program at Yale in 1988, my goal was to combine state of the art patient care with clinical research. We often talk about bench to bedside as the framework for discovery in medicine but in fact most innovations related to disease proceed the other way: from bedside to bench. A doctor recognizes a pattern in a particular disease or makes a novel observation in a patient and that raises questions for investigation in the laboratory. Early in my career I observed an increase in basal cell cancer in young women. This was unusual for a disease typically noted in older men. Investigation into sun practices and related issues became the basis for a component of a SPORE grant that the department was awarded. Because we treat a very large number of skin cancers and melanoma and perform reconstructive surgery, a large focus of our research has also been on wound healing. We have published on the use of artificial skin substitutes to facilitate healing and I am involved with a commercial entity with a connexin43 molecule currently in clinical trials. In a broad sense my research collaborations extend from skin cancer in the immune compromised, to the biology of skin cancer in general and its epidemiology to the development of innovative treatments.

Medical Research Interests

Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Epidermis; Genes, p53; Head and Neck Neoplasms; Keratosis, Actinic; Melanoma; Mohs Surgery; Skin Neoplasms; Ultraviolet Rays; Wound Healing

Research at a Glance

Yale Co-Authors

Frequent collaborators of David J Leffell's published research.

Publications

2025

2024

2023

2022

2020

2019

2018

Academic Achievements & Community Involvement

Activities

  • activity

    Society for Investigative Dermatology, Committee on Resident/ Fellow Programs

  • activity

    Women's Dermatologic Society, Networking Committee

  • activity

    Women's Dermatologic Society, Mentorship Award Committee

Honors

  • honor

    Best Doctors in America

  • honor

    Connecticut Magazine Top Docs 2016

  • honor

    Best Cancer Doctors in America

  • honor

    Best Doctors in New York

Get In Touch

Contacts

Appointment Number
Clinic Fax Number
Mailing Address

Dermatology

40 Temple Street,

New Haven, CT 06510

United States

Administrative Support

Locations

  • Yale Dermatologic Surgery

    Academic Office

    Temple Medical Center

    40 Temple Street, Ste 5A

    New Haven, CT 06510