2020
Predicting outcomes following second intent healing of periocular surgical defects
Kibbi N, Khan Y, Leffell DJ, Christensen SR, Suozzi KC. Predicting outcomes following second intent healing of periocular surgical defects. Archives Of Dermatological Research 2020, 313: 483-489. PMID: 32833078, DOI: 10.1007/s00403-020-02122-w.Peer-Reviewed Original ResearchConceptsMohs micrographic surgeryMedial canthusSingle academic surgical centerAcademic surgical centerConclusionsThis retrospective studyMedial canthal lesionAverage defect diameterMethodsRetrospective analysisTumor characteristicsPeriocular tumorsRetrospective studyPoor outcomePeriocular lesionsSurgical centersMicrographic surgeryWorse outcomesAnatomic locationAimThe purposeScar outcomeLarge lesionsUpper eyelidEyelid marginLid marginSurgical defectsLower eyelid
2019
Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness
Kibbi N, Zhang Y, Leffell DJ, Christensen SR. Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness. Journal Of The American Academy Of Dermatology 2019, 82: 1124-1130. PMID: 31712171, DOI: 10.1016/j.jaad.2019.10.079.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAminolevulinic AcidAnalysis of VarianceBiopsy, NeedleCarcinoma in SituCarcinoma, Squamous CellCohort StudiesDisease-Free SurvivalFemaleHumansImmunohistochemistryLogistic ModelsMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingPhotochemotherapyPrognosisRetrospective StudiesSkin NeoplasmsSurvival AnalysisTreatment OutcomeTumor BurdenConceptsCutaneous squamous cell carcinomaALA incubation timeSquamous cell carcinomaTumor diameterALA-PDTSubsequent recurrenceCell carcinomaAnatomic locationInitial complete response ratePhotodynamic therapyCases of SCCISMultivariate analysis factorsComplete response rateMedical record reviewEffectiveness of PDTPatient demographicsClinical responseMedian timeRetrospective reviewRecord reviewRetrospective studyTreatment detailsSingle institutionEffective treatmentResponse rate
2018
Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma
Totonchy MB, Leventhal JS, Ko CJ, Leffell DJ. Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma. Dermatologic Surgery 2018, 44: 1466-1470. PMID: 29360655, DOI: 10.1097/dss.0000000000001465.Peer-Reviewed Original Research
2017
Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases
Ko CJ, Glusac EJ, McNiff JM, Rodic N, Leffell DJ. Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases. Journal Of The American Academy Of Dermatology 2017, 77: 1126-1132.e1. PMID: 28709693, DOI: 10.1016/j.jaad.2017.04.1119.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaProminent cytologic atypiaMultiple squamous cell carcinomasCytologic atypiaSquamous proliferationTP53 mutationsDetectable TP53 mutationsLegs of womenFollicle-like structuresCell carcinomaHistopathologic findingsMultiple lesionsSCC lesionsHistopathologic analysisTP53 sequencingNumerous tumorsSmall seriesTP53 variantsClinical phenotypeKeratoacanthomaLesionsTumorsDifferent patientsAtypiaReactive phenomenonWell‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63
Panse G, Cowper SE, Leffell DJ, Pulitzer M, Ko CJ. Well‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63. Journal Of Cutaneous Pathology 2017, 44: 557-562. PMID: 28417484, DOI: 10.1111/cup.12952.Peer-Reviewed Original ResearchConceptsCutaneous adnexal neoplasmsAdnexal neoplasmsNeuroendocrine tumorsAdnexal tumorsBenign skin adnexal tumorCutaneous adnexal tumorsAggressive metastatic diseaseLow-grade tumorsSkin adnexal tumorsMajority of casesMetastatic diseaseMetastatic adenocarcinomaCarcinoid tumorsCytokeratin 5/6Diagnostic challengeDifferential diagnosisImmunohistochemical stainsCK5/6Diagnostic utilityPrimary siteTumorsNeoplasmsFirst signWDNETsP63
2016
Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity
Munday WR, Leffell DJ, McNiff JM, Ko CJ. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity. Journal Of Cutaneous Pathology 2016, 43: 759-765. PMID: 27220356, DOI: 10.1111/cup.12738.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaMultiple squamous cell carcinomasCutaneous squamous cell carcinomaHistopathologic featuresCell carcinomaLower extremitiesMultiple cutaneous squamous cell carcinomasRetrospective chart reviewAmerican Joint CommitteeCancer staging criteriaDistinct clinical subtypesChart reviewPerineural invasionActinic keratosisStaging criteriaClinical subtypesMost lesionsStage IJoint CommitteeStage IIKeratoacanthomaPatientsCarcinomaTumorsSubtypes
2015
Randomized comparison of the safety of Flublok® versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥50 years of age
Izikson R, Leffell DJ, Bock SA, Patriarca PA, Post P, Dunkle LM, Cox MM. Randomized comparison of the safety of Flublok® versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥50 years of age. Vaccine 2015, 33: 6622-6628. PMID: 26529070, DOI: 10.1016/j.vaccine.2015.10.097.Peer-Reviewed Original ResearchConceptsYears of ageVaccine groupInfluenza vaccineHypersensitivity reactionsPossible hypersensitivityOverall adverse event profileUnsolicited adverse eventsInactivated influenza vaccineAdverse event profileSeasonal influenza vaccineIncidence of hypersensitivityAdverse event termsAdverse eventsRandomized comparisonEvent profileClinical criteriaClinical trialsStable adultsAfluriaCase recordsHealthy adultsTreatment assignmentHypersensitivityVaccineFlublokFamily history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype
Berlin NL, Cartmel B, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype. Cancer Epidemiology 2015, 39: 1078-1083. PMID: 26381319, PMCID: PMC4679454, DOI: 10.1016/j.canep.2015.09.005.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaBasal cell carcinomaFamily historySkin cancerAge of onsetLifestyle factorsBenign skin conditionsStrong risk factorFirst-degree relativesMC1R genotypeCell carcinomaRisk factorsAge 40High riskLifestyle characteristicsAge 50Particular malignancySkin conditionsBCC casesCancerGenetic susceptibilitySaliva samplesMultivariate modelIndividual riskAffected relativesA Strategy for the Successful Management of Dermatofibrosarcoma Protuberans
Goldberg C, Hoang D, McRae M, Chung C, Leffell DJ, Narayan D. A Strategy for the Successful Management of Dermatofibrosarcoma Protuberans. Annals Of Plastic Surgery 2015, 74: 80-84. PMID: 23788146, DOI: 10.1097/sap.0b013e3182898692.Peer-Reviewed Original ResearchConceptsSurgical excisionPositive marginsDermatofibrosarcoma protuberansMohs surgeryNational Comprehensive Cancer Network guidelinesDisease recurrence/persistenceMargin sizeClear histological marginsComplications of reconstructionInitial surgical resectionRecurrence/persistenceTraditional surgical excisionSoft tissue sarcomasMethod of treatmentExcision patientsHistological marginsSurgery groupSubclinical involvementSurgical resectionMargin statusDistant metastasisNetwork guidelinesTissue sarcomasClinical variablesTumor resection
2013
Intralesional interferon alfa-2b for refractory, recurrent squamous cell carcinoma of the face
Hanlon A, Kim J, Leffell DJ. Intralesional interferon alfa-2b for refractory, recurrent squamous cell carcinoma of the face. Journal Of The American Academy Of Dermatology 2013, 69: 1070-1072. PMID: 24238178, DOI: 10.1016/j.jaad.2013.02.032.Peer-Reviewed Original ResearchCutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas
Kim C, Ko CJ, Leffell DJ. Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas. Journal Of The American Academy Of Dermatology 2013, 70: 70-74. PMID: 24210370, DOI: 10.1016/j.jaad.2013.09.026.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaSquamous cell carcinomaLower extremitiesCell carcinomaClinical featuresIncidence of SCCPrevalence of SCCDistinct subsetsDistinctive clinical featuresNumber of patientsBasal cell carcinomaClinical outcomesSquamous cellsBiologic behaviorSame patientGeneral populationPatientsCarcinomaStudy periodAdditional studiesDefinitive conclusionsIncidenceExtremitiesOutcomesTreatmentSingle v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status
Scarmo S, Cartmel B, Lin H, Leffell DJ, Ermakov IV, Gellermann W, Bernstein PS, Mayne ST. Single v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status. British Journal Of Nutrition 2013, 110: 911-917. PMID: 23351238, PMCID: PMC3696054, DOI: 10.1017/s000711451200582x.Peer-Reviewed Original ResearchConceptsSkin carotenoid statusRecent sun exposureCarotenoid statusSkin carotenoidsSun exposureRR measuresFruit/vegetable intakeLower carotenoid statusSeason of measurementMean ageNon-invasive methodVegetable intakeInverse associationDietary dataTime pointsSignificant predictorsMultiple measuresPositive associationIntakeBiomarkersPresent studyStatusPredictorsAssociationExposure
2012
Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases
Jedrych J, Leffell D, McNiff JM. Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases. Journal Of Cutaneous Pathology 2012, 39: 317-323. PMID: 22335590, DOI: 10.1111/j.1600-0560.2012.01876.x.Peer-Reviewed Original ResearchConceptsDesmoplastic trichoepitheliomaPerineural involvementDesmoplastic stromaMicrocystic adnexal carcinomaBasal cell carcinomaBenign epithelial proliferationsP75 neurotrophin receptorMiddle-aged womenBenign follicular tumorsCK20-positive cellsSmall dermal nervesAdnexal carcinomaCell carcinomaTumor recurrenceTypical presentationBasaloid epitheliumDermal nervesPerineural spaceNeurotrophin receptorBasaloid cellsEpithelial proliferationDermal proliferationDiffuse expressionFollicular tumorsPatients
2010
Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake
Mayne ST, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W. Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake. American Journal Of Clinical Nutrition 2010, 92: 794-800. PMID: 20685953, PMCID: PMC3133234, DOI: 10.3945/ajcn.2010.29707.Peer-Reviewed Original ResearchConceptsIntraclass correlation coefficientDermal carotenoidsDermal biopsiesRR measuresBiomarkers of fruitDietary carotenoid intakeVegetable intakeCarotenoid statusCarotenoid intakeStudy of nutritionNoninvasive assessmentBiopsyBiomarkersSkin pigmentationTotal carotenoidsHuman skinIntakeWkInner armLycopeneValid methodArmSignificant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults
Scarmo S, Cartmel B, Lin H, Leffell DJ, Welch E, Bhosale P, Bernstein PS, Mayne ST. Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults. Archives Of Biochemistry And Biophysics 2010, 504: 34-39. PMID: 20637178, PMCID: PMC2957565, DOI: 10.1016/j.abb.2010.07.004.Peer-Reviewed Original ResearchConceptsHuman skin photoprotectionRespective plasma levelsHigh-performance liquid chromatographyHuman skinPlasma levelsBlood samplesHealthy humansHealthy adultsHydrocarbon carotenoidsDermal biopsiesSkin photoprotectionSimilar proportionsSkinSignificant correlationPerformance liquid chromatographyIndividual carotenoid contentTotal carotenoidsRelative levelsLycopeneLiquid chromatographyBiopsyPlasmaLutein
2009
Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining
Ko CJ, Leffell DJ, McNiff JM. Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining. Journal Of Cutaneous Pathology 2009, 36: 448-452. PMID: 19278431, DOI: 10.1111/j.1600-0560.2008.01083.x.Peer-Reviewed Original ResearchConceptsCytokeratin 5/6Adenosquamous carcinomaPrimary cutaneous originSubset of casesCutaneous originMetastatic adenocarcinomaAppropriate therapyRare tumorGlandular differentiationCytokeratin 7Such tumorsDiffuse positivityLuminal areaTumorsCarcinomaAggressive behaviorP63StainClose associationAdenocarcinomaTherapyLesionsCasesPositivity
2007
Correlation of Embryonic Fusion Planes with the Anatomical Distribution of Basal Cell Carcinoma
NEWMAN JC, LEFFELL DJ. Correlation of Embryonic Fusion Planes with the Anatomical Distribution of Basal Cell Carcinoma. Dermatologic Surgery 2007, 33: 957-965. PMID: 17661939, DOI: 10.1111/j.1524-4725.2007.33198.x.Peer-Reviewed Original Research
2005
Bilobed transposition flap
Aasi SZ, Leffell DJ. Bilobed transposition flap. Dermatologic Clinics 2005, 23: 55-64. PMID: 15620619, DOI: 10.1016/j.det.2004.08.004.Peer-Reviewed Original Research
2002
Clinical Efficacy of Devices for Nonablative Photorejuvenation
Leffell DJ. Clinical Efficacy of Devices for Nonablative Photorejuvenation. JAMA Dermatology 2002, 138: 1503-1508. PMID: 12437458, DOI: 10.1001/archderm.138.11.1503.Peer-Reviewed Original ResearchHuman Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery
Carucci JA, Kolenik SA, Leffell DJ. Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery. Dermatologic Surgery 2002, 28: 340-343. PMID: 11966793, DOI: 10.1046/j.1524-4725.2002.01143.x.Peer-Reviewed Original ResearchConceptsHuman cadaveric allograftMohs micrographic surgeryBasal cell carcinomaCadaveric allograftsCell carcinomaMicrographic surgeryHealing timeSkin cancerInfiltrative basal cell carcinomaNasal defectsAverage healing timeWound infectionHypergranulation tissueCancer histologyImmediate reconstructionMedical statusPatientsExtensive proceduresUseful alternativeAllograftsSurgeryCarcinomaCosmesisCancerDefect size