2020
Predicting outcomes following second intent healing of periocular surgical defects
Kibbi N, Khan Y, Leffell DJ, Christensen SR, Suozzi KC. Predicting outcomes following second intent healing of periocular surgical defects. Archives Of Dermatological Research 2020, 313: 483-489. PMID: 32833078, DOI: 10.1007/s00403-020-02122-w.Peer-Reviewed Original ResearchConceptsMohs micrographic surgeryMedial canthusSingle academic surgical centerAcademic surgical centerConclusionsThis retrospective studyMedial canthal lesionAverage defect diameterMethodsRetrospective analysisTumor characteristicsPeriocular tumorsRetrospective studyPoor outcomePeriocular lesionsSurgical centersMicrographic surgeryWorse outcomesAnatomic locationAimThe purposeScar outcomeLarge lesionsUpper eyelidEyelid marginLid marginSurgical defectsLower eyelid
2019
Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease
Kibbi N, Suozzi KC, Ko CJ, Leffell DJ. Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease. Dermatologic Surgery 2019, Publish Ahead of Print: &na;. PMID: 31260417, DOI: 10.1097/dss.0000000000001706.Peer-Reviewed Original Research
2018
Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma
Totonchy MB, Leventhal JS, Ko CJ, Leffell DJ. Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma. Dermatologic Surgery 2018, 44: 1466-1470. PMID: 29360655, DOI: 10.1097/dss.0000000000001465.Peer-Reviewed Original Research
2015
Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach
Christensen SR, McNiff JM, Cool AJ, Aasi SZ, Hanlon AM, Leffell DJ. Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach. Journal Of The American Academy Of Dermatology 2015, 74: 356-362. PMID: 26670714, DOI: 10.1016/j.jaad.2015.09.060.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaHair follicle infundibulumFollicular invasionCell carcinomaMohs micrographic surgeryHair follicle epitheliumAdditional patientsIntraoperative pathologyOptimal therapyRetrospective reviewTreatment failureProspective evaluationSingle institutionHistopathologic assessmentMicrographic surgeryMost tumorsDeep invasionTreatment approachesPathology specimensFollicle epitheliumLower follicleSCCISSurgeryCarcinomaInvasionMelanoma in situ Part II. Histopathology, treatment, and clinical management
Higgins HW, Lee KC, Galan A, Leffell DJ. Melanoma in situ Part II. Histopathology, treatment, and clinical management. Journal Of The American Academy Of Dermatology 2015, 73: 193-203. PMID: 26183968, DOI: 10.1016/j.jaad.2015.03.057.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAminoquinolinesBiopsy, NeedleCarcinoma in SituFemaleHumansImiquimodImmunohistochemistryImmunotherapyInjections, IntralesionalInterferon-alphaLaser TherapyMaleMelanomaMohs SurgeryNeoplasm InvasivenessNeoplasm StagingPrognosisRandomized Controlled Trials as TopicSkin NeoplasmsTreatment OutcomeA Strategy for the Successful Management of Dermatofibrosarcoma Protuberans
Goldberg C, Hoang D, McRae M, Chung C, Leffell DJ, Narayan D. A Strategy for the Successful Management of Dermatofibrosarcoma Protuberans. Annals Of Plastic Surgery 2015, 74: 80-84. PMID: 23788146, DOI: 10.1097/sap.0b013e3182898692.Peer-Reviewed Original ResearchConceptsSurgical excisionPositive marginsDermatofibrosarcoma protuberansMohs surgeryNational Comprehensive Cancer Network guidelinesDisease recurrence/persistenceMargin sizeClear histological marginsComplications of reconstructionInitial surgical resectionRecurrence/persistenceTraditional surgical excisionSoft tissue sarcomasMethod of treatmentExcision patientsHistological marginsSurgery groupSubclinical involvementSurgical resectionMargin statusDistant metastasisNetwork guidelinesTissue sarcomasClinical variablesTumor resection
2010
Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature
Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R. Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature. American Journal Of Dermatopathology 2010, 32: 287-292. PMID: 20010402, DOI: 10.1097/dad.0b013e3181b623c4.Peer-Reviewed Case Reports and Technical NotesConceptsDuctal carcinomaShave biopsyEccrine ductal carcinomaInitial shave biopsySuperficial shave biopsiesMohs micrographic surgeryRare adnexal tumorTreatment guidelinesCase reportDiagnostic challengeMicrographic surgeryBiologic behaviorComplete excisionAdnexal tumorsImmunohistochemical approachBiopsyCarcinomaRare variantsTumorsDiagnostic purposesPatientsSurgeryNeoplasmsExcisionCancer
2009
Mohs micrographic surgery histopathology concordance
Mariwalla K, Aasi SZ, Glusac EJ, Leffell DJ. Mohs micrographic surgery histopathology concordance. Journal Of The American Academy Of Dermatology 2009, 60: 94-98. PMID: 19103361, PMCID: PMC2632938, DOI: 10.1016/j.jaad.2008.09.061.Peer-Reviewed Original ResearchMeSH KeywordsFrozen SectionsHumansMohs SurgeryObserver VariationPathologyRecordsRetrospective StudiesSkin Neoplasms
2005
Mohs micrographic surgery: established uses and emerging trends.
Pennington BE, Leffell DJ. Mohs micrographic surgery: established uses and emerging trends. Oncology 2005, 19: 1165-71; discussion 1171-2, 1175. PMID: 16255133.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaBasal cell carcinomaMohs micrographic surgeryCell carcinomaMicrographic surgeryCommon cutaneous neoplasmsConventional surgical excisionExtramammary Paget's diseaseMicrocystic adnexal carcinomaMerkel cell carcinomaCutaneous neoplasmsPaget's diseaseResidual tumorSurgical excisionAdnexal carcinomaCommon cancerCutaneous tumorsSurgical techniqueDermatofibrosarcoma protuberansCarcinomaDeep marginTissue conservationSurgeryTumorsDisease
2003
Complications in Dermatologic Surgery: How Safe Is Safe?
Aasi SZ, Leffell DJ. Complications in Dermatologic Surgery: How Safe Is Safe? JAMA Dermatology 2003, 139: 213-214. PMID: 12588228, DOI: 10.1001/archderm.139.2.213.Peer-Reviewed Original Research
2002
Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery
Carucci JA, Kolenik SA, Leffell DJ. Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery. Dermatologic Surgery 2002, 28: 340-343. PMID: 11966793, DOI: 10.1046/j.1524-4725.2002.01143.x.Peer-Reviewed Original ResearchConceptsHuman cadaveric allograftMohs micrographic surgeryBasal cell carcinomaCadaveric allograftsCell carcinomaMicrographic surgeryHealing timeSkin cancerInfiltrative basal cell carcinomaNasal defectsAverage healing timeWound infectionHypergranulation tissueCancer histologyImmediate reconstructionMedical statusPatientsExtensive proceduresUseful alternativeAllograftsSurgeryCarcinomaCosmesisCancerDefect size
1999
Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery.
McGovern T, Grossman D, Fitzgerald D, Glusac E, Leffell D. Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery. JAMA Dermatology 1999, 135: 1557-9. PMID: 10606080, DOI: 10.1001/archderm.135.12.1557.Peer-Reviewed Original ResearchMohs Surgery: The Informed View
McGovern T, Leffell D. Mohs Surgery: The Informed View. JAMA Dermatology 1999, 135: 1255-1259. PMID: 10522675, DOI: 10.1001/archderm.135.10.1255.Peer-Reviewed Original ResearchUse of a Lyophilized Bovine Collagen Matrix in Postoperative Wound Healing
Kolenik S, McGovern T, Leffell D. Use of a Lyophilized Bovine Collagen Matrix in Postoperative Wound Healing. Dermatologic Surgery 1999, 25: 303-307. PMID: 10417587, DOI: 10.1046/j.1524-4725.1999.08230.x.Peer-Reviewed Original ResearchConceptsMohs micrographic surgeryBovine collagen matrixMicrographic surgeryWound careControl groupWound healingMinority of patientsPostoperative wound healingSecond intention healingCollagen matrixManagement of defectsWound infectionDressing changesAdverse reactionsImmediate reconstructionAllergic reactionsComplete healingAnatomic sitesRapid wound healingSurgical defectsStudy woundsLarger studySecond intentionBiological dressingSurgery
1995
The Use of Cryopreserved Human Skin Allografts in Wound Healing following Mohs Surgery
KOLENIK S, LEFFELL D. The Use of Cryopreserved Human Skin Allografts in Wound Healing following Mohs Surgery. Dermatologic Surgery 1995, 21: 615-620. PMID: 7606373, DOI: 10.1111/j.1524-4725.1995.tb00517.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Basal CellCarcinoma, Squamous CellCryopreservationDermatologic Surgical ProceduresFemaleFollow-Up StudiesGraft RejectionGraft SurvivalGranulation TissueHumansMaleMiddle AgedMohs SurgerySkinSkin CareSkin NeoplasmsSkin TransplantationSurgical Wound InfectionTransplantation, HomologousTreatment OutcomeWound HealingConceptsHuman skin allograftsWound careSkin allograftsImmediate reconstructionMohs surgeryFull-thickness skin graftingMinority of patientsEvidence of infectionExcision of tumorSkin cancer patientsFull‐thickness cutaneous defectGranulation tissue productionFull-thickness skinCancer patientsSkin graftingReconstructive proceduresWound coverageSafe alternativeBiological dressingCutaneous defectsPatientsRapid healingWound healingHealingCare
1991
An educational device for Mohs micrographic surgery. A three-dimensional model of basal cell carcinoma.
Leffell D. An educational device for Mohs micrographic surgery. A three-dimensional model of basal cell carcinoma. Dermatologic Surgery 1991, 17: 498-501. PMID: 2040753.Peer-Reviewed Original Research