Chiayu Chiu, PhD
Associate Research Scientist in NeuroscienceCards
About
Research
Publications
2024
Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina
Estay S, Morales-Moraga C, Vielma A, Palacios-Muñoz A, Chiu C, Chávez A. Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina. IScience 2024, 27: 109920. PMID: 38799553, PMCID: PMC11126983, DOI: 10.1016/j.isci.2024.109920.Peer-Reviewed Original ResearchA17 amacrine cellsRod bipolar cellsVisual processingType 1 cannabinoid receptorGABAergic feedback inhibitionNon-canonical mechanismRat retinal slicesAmacrine cellsCB1R activationRetinal slicesGlutamate releaseInner retinaRat retinaRetinal neuronsRod pathwayCB1RExchange proteinFeedback inhibitionBipolar cellsRod-drivenAxon terminalsTime courseGABAVisual responsesRetina
2023
Microbiota and Diapause-Induced Neuroprotection Share a Dependency on Calcium But Differ in Their Effects on Mitochondrial Morphology
Delgado S, Urrutia A, Gutzwiller F, Chiu C, Calixto A. Microbiota and Diapause-Induced Neuroprotection Share a Dependency on Calcium But Differ in Their Effects on Mitochondrial Morphology. ENeuro 2023, 10: eneuro.0424-22.2023. PMID: 37385728, PMCID: PMC10368204, DOI: 10.1523/eneuro.0424-22.2023.Peer-Reviewed Original ResearchConceptsCaenorhabditis elegans</i>Length of mitochondriaDiapause entryLactate-producing bacteriaReverse geneticsGut microbiotaMitochondrial morphologyTranscriptomic approachMitochondrial sizeMitochondrial functionMicrobiotaMechanistic commonalitiesEnvironmental variablesBacteriaMCU-1GenesNeuronal functionMultiple mechanismsCalcium homeostasisDiapauseNeuronal degenerationNeuronal protectionRegeneration of damaged neuronsFood deprivationTranscriptome
2022
Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease
Meza R, Ancatén-González C, Chiu C, Chávez A. Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease. Frontiers In Cellular Neuroscience 2022, 16: 864828. PMID: 35518644, PMCID: PMC9062234, DOI: 10.3389/fncel.2022.864828.Peer-Reviewed Original ResearchTransient receptor potential vanilloid 1Synaptic plasticityTRPV1 functionActivity-dependent synaptic changesLigand-gated nonselective cation channelCentral synapsesNonselective cation channelsRegulate synaptic functionVanilloid 1Pain sensationCation channelsHealth and DiseaseSynaptic efficacySynaptic changesBrain regionsPostsynaptic compartmentsNeurotransmitter releasePresynaptic terminalsTherapeutic treatmentSynaptic functionBrain disordersPotential roleSynapsesBrainPainLong-Range GABAergic Projections of Cortical Origin in Brain Function
Urrutia-Piñones J, Morales-Moraga C, Sanguinetti-González N, Escobar A, Chiu C. Long-Range GABAergic Projections of Cortical Origin in Brain Function. Frontiers In Systems Neuroscience 2022, 16: 841869. PMID: 35392440, PMCID: PMC8981584, DOI: 10.3389/fnsys.2022.841869.Peer-Reviewed Original Research
2020
Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus
Fuenzalida M, Chiu C, Chávez A. Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus. Neuroscience 2020, 456: 50-59. PMID: 32828940, DOI: 10.1016/j.neuroscience.2020.08.015.Peer-Reviewed Original ResearchConceptsSpike timing dependent synaptic plasticityTiming-dependent plasticityCellular basis of learningMagnitude of long-term changesMuscarinic receptorsInhibitory synapsesMuscarinic regulationSynaptic transmissionSynaptic plasticityShape learningCentral synapsesBasis of learningCellular basisNetwork activityBrain network activityLong-term changesAcetylcholineHippocampusLearningSynapsesSTDPBrainMuscarinicMemoryReceptors
2019
Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity
Chiu CQ, Barberis A, Higley MJ. Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity. Nature Reviews Neuroscience 2019, 20: 272-281. PMID: 30837689, DOI: 10.1038/s41583-019-0141-5.Peer-Reviewed Original ResearchConceptsGABAergic synaptic plasticityInhibitory GABAergic synapsesPostsynaptic action potentialsInhibitory synaptic strengthGABAergic synapsesSynaptic excitationLong-term plasticityGlutamatergic signalingNeuronal activitySynaptic plasticityNeuronal circuitsAction potentialsSynaptic strengthIndividual neuronsCellular mechanismsLines of evidenceBody of literaturePlasticityNeuronsFunctional stabilitySynapses
2018
Input-Specific NMDAR-Dependent Potentiation of Dendritic GABAergic Inhibition
Chiu CQ, Martenson JS, Yamazaki M, Natsume R, Sakimura K, Tomita S, Tavalin SJ, Higley MJ. Input-Specific NMDAR-Dependent Potentiation of Dendritic GABAergic Inhibition. Neuron 2018, 97: 368-377.e3. PMID: 29346754, PMCID: PMC5777295, DOI: 10.1016/j.neuron.2017.12.032.Peer-Reviewed Original ResearchConceptsDendritic inhibitionInput-specific long-term potentiationNMDA-type glutamate receptorsGABAergic inhibitory synapsesSomatostatin-expressing interneuronsGABA-A receptorsNormal brain functionLong-term potentiationForms of plasticityHomeostatic cellular mechanismsGABAergic inhibitionSynaptic excitationPerisomatic inhibitionPostsynaptic spikingInhibitory synapsesLong-term plasticityGlutamate receptorsInhibitory inputsSynaptic transmissionDependent potentiationCortical circuitsGenetic deletionBrain functionNeuronal dendritesCellular mechanisms
2013
Wavelength-Selective One- and Two-Photon Uncaging of GABA
Amatrudo JM, Olson JP, Lur G, Chiu CQ, Higley MJ, Ellis-Davies GC. Wavelength-Selective One- and Two-Photon Uncaging of GABA. ACS Chemical Neuroscience 2013, 5: 64-70. PMID: 24304264, PMCID: PMC3894722, DOI: 10.1021/cn400185r.Peer-Reviewed Original ResearchCompartmentalization of GABAergic Inhibition by Dendritic Spines
Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ. Compartmentalization of GABAergic Inhibition by Dendritic Spines. Science 2013, 340: 759-762. PMID: 23661763, PMCID: PMC3752161, DOI: 10.1126/science.1234274.Peer-Reviewed Original ResearchConceptsGABAergic inhibitionDendritic spinesPerisomatic inhibitory synapsesPyramidal cell dendritesTwo-photon calcium imagingAction potential outputAcid-mediated inhibitionIndividual dendritic spinesGABAergic controlGABAergic synapsesPyramidal neuronsCell dendritesInhibitory synapsesNeuronal activityCalcium imagingSpine headsInhibitory actionNeocortexInhibitionSpineSynapsesCompartmentalized controlCritical roleSignalingPostsynapticOptically Selective Two-Photon Uncaging of Glutamate at 900 nm
Olson JP, Kwon HB, Takasaki KT, Chiu CQ, Higley MJ, Sabatini BL, Ellis-Davies GC. Optically Selective Two-Photon Uncaging of Glutamate at 900 nm. Journal Of The American Chemical Society 2013, 135: 5954-5957. PMID: 23577752, PMCID: PMC4079120, DOI: 10.1021/ja4019379.Peer-Reviewed Original ResearchConceptsTwo-photon excitation