2023
Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach
Valerio E, Stocchero M, Pirillo P, D’Errico I, Bonadies L, Galderisi A, Giordano G, Baraldi E. Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach. EBioMedicine 2023, 92: 104636. PMID: 37257315, PMCID: PMC10244906, DOI: 10.1016/j.ebiom.2023.104636.Peer-Reviewed Original ResearchConceptsAsphyctic infantsHypoxic-ischemic encephalopathyHealthy newbornsPerinatal asphyxiaMetabolic effectsSingle-center longitudinal studyDays of lifeTherapeutic hypothermiaUrinary metabolomePathobiological mechanismsSteroid levelsInfantsHypothermiaSteroidogenesis pathwayUntargeted metabolomics approachNewbornsSteroid contentTranslational researchLongitudinal studyPotential roleAsphyxiaEncephalopathyMetabolomics approachPathway analysisUntargeted metabolomics
2020
Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study
Galderisi A, Tricò D, Man C, Santoro N, Pierpont B, Groop L, Cobelli C, Caprio S. Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgz207. PMID: 31972003, PMCID: PMC6977541, DOI: 10.1210/clinem/dgz207.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAllelesChildCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseGenotypeGlucoseGlucose IntoleranceGlucose Tolerance TestHumansInsulin SecretionInsulin-Secreting CellsLongitudinal StudiesMalePediatric ObesityPrediabetic StateTime FactorsTranscription Factor 7-Like 2 ProteinYoung AdultConceptsOral glucose tolerance testTCF7L2 rs7903146 variantΒ-cell responsivenessObese youthT risk alleleDisposition indexGlucose peakRs7903146 variantTCF7L2 rs7903146Lower disposition indexGlucose tolerance testOral minimal modelGlucose toleranceOral challengeDiabetes riskTolerance testInsulin sensitivityHigh glucose concentrationsLate peak groupMetabolic phenotypeGlucose concentrationLongitudinal studyReproducible markerPrevalenceRs7903146
2016
High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004–2013
Cherubini V, Skrami E, Ferrito L, Zucchini S, Scaramuzza A, Bonfanti R, Buono P, Cardella F, Cauvin V, Chiari G, d′Annunzio G, Frongia A, Iafusco D, Patera I, Toni S, Tumini S, Rabbone I, Lombardo F, Carle F, Gesuita R, Lera R, De Luna L, Gualtieri A, Zecchino C, Piccinno E, Reinstadler P, Prandi E, Gallo F, Morganti G, Ripoli C, La Loggia A, Scanu P, Cardinale G, Tomaselli L, Citriniti F, Lazzaro N, De Donno V, Mainetti B, Coccioli M, Maccioni R, Marongiu U, Bruzzese M, Iannilli A, Pardi D, Confetto S, Zanfardino A, Iughetti L, Franzese A, Cadario F, Milia A, Piredda G, Soro M, Correddu A, Galderisi A, De Berardinis F, Federico G, Zanette G, Suprani T, Pedini A, Bitti M, Delvecchio M, Trada M, Meloni G, Gaiero A, Bulciolu P, Guerraggio L, Faleschini E, Zanatta M, Salvatoni A, Maffeis C, Arnaldi C. High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004–2013. Scientific Reports 2016, 6: 38844. PMID: 27991500, PMCID: PMC5171855, DOI: 10.1038/srep38844.Peer-Reviewed Original ResearchConceptsSevere diabetic ketoacidosisDiabetic ketoacidosisType 1 diabetesDKA frequencyAge groupsLongitudinal population-based studyType 1 diabetes diagnosisMultiple logistic regression modelPopulation-based studyNationwide longitudinal studyYears of ageLogistic regression modelsItalian childrenFamily historyHigh riskMild/Diabetes diagnosisKetoacidosisHealthcare strategiesYoung age childrenDiabetesEarly detectionDiagnosisLongitudinal studyTime trends