2023
Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach
Valerio E, Stocchero M, Pirillo P, D’Errico I, Bonadies L, Galderisi A, Giordano G, Baraldi E. Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach. EBioMedicine 2023, 92: 104636. PMID: 37257315, PMCID: PMC10244906, DOI: 10.1016/j.ebiom.2023.104636.Peer-Reviewed Original ResearchConceptsAsphyctic infantsHypoxic-ischemic encephalopathyHealthy newbornsPerinatal asphyxiaMetabolic effectsSingle-center longitudinal studyDays of lifeTherapeutic hypothermiaUrinary metabolomePathobiological mechanismsSteroid levelsInfantsHypothermiaSteroidogenesis pathwayUntargeted metabolomics approachNewbornsSteroid contentTranslational researchLongitudinal studyPotential roleAsphyxiaEncephalopathyMetabolomics approachPathway analysisUntargeted metabolomics
2022
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study
Galderisi A, Tordin M, Suppiej A, Cainelli E, Baraldi E, Trevisanuto D. Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study. European Journal Of Pediatrics 2022, 182: 837-844. PMID: 36484862, PMCID: PMC9899169, DOI: 10.1007/s00431-022-04694-3.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyTherapeutic hypothermiaNeurodevelopmental outcomesLactate ratioDay 1Severe hypoxic-ischemic encephalopathyNew risk markerSevere hypoNeonatal hypoglycemiaMetabolic outcomesRisk markersObservational studyMetabolic variablesDay 2InfantsLactate concentrationEncephalopathyLactate kineticsNeurodevelopmentMetabolic fuelsNeonatesStrongest predictorHypothermiaOutcomesGlucose