Lack of Evidence for a Causal Role of Hyperinsulinemia in the Progression of Obesity in Children and Adolescents: A Longitudinal Study.
Halloun R, Galderisi A, Caprio S, Weiss R. Lack of Evidence for a Causal Role of Hyperinsulinemia in the Progression of Obesity in Children and Adolescents: A Longitudinal Study. Diabetes Care 2022, 45: 1400-1407. PMID: 35235641, PMCID: PMC9210872, DOI: 10.2337/dc21-2210.Peer-Reviewed Original ResearchConceptsDegree of obesityOral glucose tolerance testCarbohydrate-insulin modelLower postprandial glucosePostprandial glucoseInsulin secretionMultivariate analysisPostprandial glucose levelsPediatric obesity clinicProgression of obesityGlucose tolerance testCurve of insulinDevelopment of obesityGreater insulin secretionGreater increaseLack of evidenceInsulinogenic indexObesity clinicLower BMIObesity managementTolerance testGlucose levelsPeak insulinHyperinsulinemiaObesityIntraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling
Presti J, Galderisi A, Doyle F, Zisser H, Dassau E, Renard E, Toffanin C, Cobelli C. Intraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling. Journal Of Diabetes Science And Technology 2022, 17: 751-756. PMID: 35144503, PMCID: PMC10210098, DOI: 10.1177/19322968221076559.Peer-Reviewed Original ResearchConceptsInsulin deliveryClosed-loop insulin deliveryInsulin kineticsIntraperitoneal insulin deliveryPeripheral hyperinsulinemiaGlycemic controlSubcutaneous routePeritoneal compartmentModel predictive controllerPhysiological routeArtificial pancreasCompartmental modelingDeliveryUVA/Padova T1D simulatorCompartmental modelProportional integral derivative (PID) controllerHyperinsulinemia