2022
Catch the Rhythm!
Eid T, Zaveri HP. Catch the Rhythm! Epilepsy Currents 2022, 22: 249-251. PMID: 36187149, PMCID: PMC9483758, DOI: 10.1177/15357597221099066.Peer-Reviewed Original ResearchPerspectives on Understanding Aberrant Brain Networks in Epilepsy
Sinha N, Joshi R, Sandhu M, Netoff T, Zaveri H, Lehnertz K. Perspectives on Understanding Aberrant Brain Networks in Epilepsy. Frontiers In Network Physiology 2022, 2: 868092. PMID: 36926081, PMCID: PMC10013006, DOI: 10.3389/fnetp.2022.868092.Peer-Reviewed Original ResearchDiscrete cortical areasAberrant brain networksGeneralized seizuresAdjacent cortexSeizure progressionCortical areasEpilepsyNeurological disordersSeizuresAnatomical configurationNetwork diseaseNeural activityBrainAberrant activityBrain networksHuman brainWidespread neural activityPatientsSurgeryCortexDiseaseNovel studyProgression331 Role of Functional Network Formation in Epilepsy
Boddeti U, Bachani M, Moyer M, Owotade J, Serra R, Zaveri H, Ksendzovsky A. 331 Role of Functional Network Formation in Epilepsy. Neurosurgery 2022, 68: 75-76. DOI: 10.1227/neu.0000000000001880_331.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEpileptogenic focusFocal epilepsyTetanic stimulationGood surgical outcomePrimary mixed culturesMulti-electrode arraysCortical epilepsyRefractory seizuresSurgical resectionSurgical outcomesEpileptogenic networksVitro stimulationCortical neuronsRat pupsSeizure onsetAxonal boutonsEpilepsy patientsSurgery decisionDaily stimulationDendritic spinesSeizure formationEpilepsyVitro modelStimulationNetwork disorder
2021
Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity
Farina MG, Sandhu MRS, Parent M, Sanganahalli BG, Derbin M, Dhaher R, Wang H, Zaveri HP, Zhou Y, Danbolt NC, Hyder F, Eid T. Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity. Epilepsia 2021, 62: 2858-2870. PMID: 34536233, PMCID: PMC9006438, DOI: 10.1111/epi.17072.Peer-Reviewed Original ResearchConceptsPostnatal brainFunctional connectivityContinuous video-electroencephalographic recordingSpontaneous recurrent seizuresPathogenesis of epilepsyGlutamine synthetase deficiencyVideo-electroencephalographic recordingsSpecific animal modelsEx vivo studySeizure thresholdAdult patientsRecurrent seizuresFocal epilepsyAdeno-associated virusHippocampal formationAnimal modelsFocal mannerEpileptic seizuresGS deficiencySmall lociSynthetase deficiencyEpilepsyGradual returnVivo studiesBrainIncreased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain
Ong C, Damisah EC, Gruenbaum SE, Dhaher R, Deng Y, Sandhu MRS, Zaveri HP, Spencer DD, Eid T. Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain. Epilepsia 2021, 62: e88-e97. PMID: 33949690, PMCID: PMC11259155, DOI: 10.1111/epi.16920.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acids, Branched-ChainBrain ChemistryChildChild, PreschoolChromatography, High Pressure LiquidDrug Resistant EpilepsyElectrocorticographyElectroencephalographyEpilepsies, PartialExtracellular SpaceFemaleGlutamic AcidHumansIsoleucineMaleMicrodialysisMiddle AgedSeizuresTandem Mass SpectrometryYoung AdultConceptsSpontaneous seizuresDrug-resistant focal epilepsyExtracellular brain glutamateHuman epileptic brainBranched-chain amino acidsBranched chain amino acids valineRefractory epilepsyBrain microdialysisGlutamatergic neurotransmissionFocal epilepsySeizure onsetBrain glutamateEpileptic brainHuman patientsSeizuresBrain regionsDialysis samplesMammalian targetEpilepsyLiquid chromatography-tandem mass spectrometryBaselineBCAAIntracranial electroencephalographyChromatography-tandem mass spectrometryPatientsAstroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy
Sandhu MRS, Gruenbaum BF, Gruenbaum SE, Dhaher R, Deshpande K, Funaro MC, Lee TW, Zaveri HP, Eid T. Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy. Frontiers In Neurology 2021, 12: 665334. PMID: 33927688, PMCID: PMC8078591, DOI: 10.3389/fneur.2021.665334.Peer-Reviewed Original ResearchMesial temporal lobe epilepsyAstroglial glutamine synthetaseTemporal lobe epilepsyLobe epilepsyIntractable mesial temporal lobe epilepsyAstrocytic glutamine synthetaseDepressive-like featuresPathogenesis of epilepsyType of epilepsyDiscrete brain regionsNeocortical epilepsyHippocampal neuronsEpilepsyBrain regionsGlutamate-ammonia ligaseLaboratory animalsPathogenesisPossible roleExperimental inhibitionGlutamine synthetaseEnzyme glutamine synthetaseDysfunctionSeizuresAstrocytesSyndrome
2020
Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy
Sandhu MRS, Dhaher R, Gruenbaum SE, Raaisa R, Spencer DD, Pavlova MK, Zaveri HP, Eid T. Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy. Frontiers In Neurology 2020, 11: 398. PMID: 32499751, PMCID: PMC7242976, DOI: 10.3389/fneur.2020.00398.Peer-Reviewed Original ResearchMesial temporal lobe epilepsyExtracellular brain glutamateSeizure onset regionTemporal lobe epilepsyType of epilepsyExcitatory neurotransmitter glutamateSeizure onset areaTranslational rodent modelEpileptogenic hippocampusLobe epilepsyIntracerebral microdialysisExtracellular glutamateBrain glutamateIndividual patientsRodent modelsControl animalsNeurotransmitter glutamateExtracellular levelsEpilepsySeizuresOnset areaCircadian-like rhythmGlutamateEssential modulatorPatientsOral glutamine supplementation increases seizure severity in a rodent model of mesial temporal lobe epilepsy
Dhaher R, Chen EC, Perez E, Rapuano A, Sandhu MRS, Gruenbaum SE, Deshpande K, Dai F, Zaveri HP, Eid T. Oral glutamine supplementation increases seizure severity in a rodent model of mesial temporal lobe epilepsy. Nutritional Neuroscience 2020, 25: 64-69. PMID: 31900092, PMCID: PMC8970572, DOI: 10.1080/1028415x.2019.1708568.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyOral glutamine supplementationSeverity of seizuresTemporal lobe epilepsyGlutamine supplementationSeizure severityLobe epilepsyRefractory mesial temporal lobe epilepsyMale Sprague-DawleySeizure frequencyConvulsive seizuresSeizure propagationEpilepsy modelSprague-DawleyEffective treatmentRodent modelsSeizuresSupplementationSeverityPotential roleEpilepsyFunction mutationsHippocampusGlutamine synthetaseDays
2018
Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker
Marino AC, Yang GJ, Tyrtova E, Wu K, Zaveri HP, Farooque P, Spencer DD, Bandt SK. Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker. Clinical Neurophysiology 2018, 130: 280-288. PMID: 30605890, DOI: 10.1016/j.clinph.2018.11.016.Peer-Reviewed Original ResearchConceptsLocalization related epilepsyEpilepsy networkSeizure onset locationSingle-patient levelCorrelated network activityPatient-specific biomarkersRelated epilepsyConnectivity patternsNeocortical epilepsyPatient levelSeizure onsetInterictal periodAnatomic locationPatientsPossible biomarkersState connectivityCortical regionsSingle-subject levelTopographic distributionCohortNetwork disorderBrain networksEpilepsyNetwork activityBiomarkersExpanding Brain–Computer Interfaces for Controlling Epilepsy Networks: Novel Thalamic Responsive Neurostimulation in Refractory Epilepsy
Gummadavelli A, Zaveri HP, Spencer DD, Gerrard JL. Expanding Brain–Computer Interfaces for Controlling Epilepsy Networks: Novel Thalamic Responsive Neurostimulation in Refractory Epilepsy. Frontiers In Neuroscience 2018, 12: 474. PMID: 30108472, PMCID: PMC6079216, DOI: 10.3389/fnins.2018.00474.Peer-Reviewed Original ResearchResponsive neurostimulationRefractory epilepsyThalamic nucleiComplex network disorderIntralaminar thalamic nucleiSubcortical brain structuresCortical onsetSeizure controlGeneralized epilepsySeizure networkSeizure onsetEpilepsy networkNeuromodulatory techniquesEpilepsyExcitatory eventsClinical treatmentBrain regionsBrain structuresSeizuresPotential targetIntracranial electroencephalographyNetwork disorderPatientsFeasible targetNeurostimulationAstrocytes and Glutamine Synthetase in Epileptogenesis
Eid T, Lee T, Patrylo P, Zaveri HP. Astrocytes and Glutamine Synthetase in Epileptogenesis. Journal Of Neuroscience Research 2018, 97: 1345-1362. PMID: 30022509, PMCID: PMC6338538, DOI: 10.1002/jnr.24267.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyLobe epilepsyAstrocytic glutamine synthetaseRole of astrocytesPotassium channel Kir4.1Important causative factorExcitatory amino acid transporters EAAT1Antiepileptogenic interventionsEpileptogenic insultAntiepileptogenic therapiesEpilepsy developmentChannel Kir4.1Aquaporin-4EpilepsyCausative factorsTransporters EAAT1New targetsSuch interventionsTransporters MCT1DysfunctionAstrocytesMetabolic mechanismsGlutamine synthetaseDownstream effectsThe roles of surgery and technology in understanding focal epilepsy and its comorbidities
Spencer DD, Gerrard JL, Zaveri HP. The roles of surgery and technology in understanding focal epilepsy and its comorbidities. The Lancet Neurology 2018, 17: 373-382. PMID: 29553383, DOI: 10.1016/s1474-4422(18)30031-0.Peer-Reviewed Original ResearchConceptsFocal epilepsyNeuropsychiatric disordersComplete seizure controlPoor postsurgical outcomeRole of surgeryRefractory focal epilepsyOnset areaComorbid neuropsychiatric disordersSeizure onset areaBehavioral seizuresSeizure controlSurgical outcomesPostsurgical outcomesEpileptogenic tissueEpilepsy networkHigh prevalenceStructural brain networksIndividualised therapyPatientsBrain regionsEpilepsyElectrophysiological recordingsIntracranial electrophysiological recordingsStructural MRIGold standard
2017
(Invited) Conjoint Measurement of Brain Electrophysiology and Neurochemistry
Zaveri H, Ganesh N, Goncharova I, Damisah E, Ong C, Perez E, Staib L, Hirsch L, Petroff O, Spencer D, Eid T. (Invited) Conjoint Measurement of Brain Electrophysiology and Neurochemistry. ECS Meeting Abstracts 2017, MA2017-02: 2329-2329. DOI: 10.1149/ma2017-02/55/2329.Peer-Reviewed Original ResearchInterictal EEG spikesBasal glutamateBrain excitabilityIntractable epilepsyEEG spikesBrain electrophysiologySpike rateBasal extracellular glutamate concentrationsIntracranial EEG monitoringExtracellular glutamate concentrationCo-localized measurementsPossible epilepsy surgeryBrain extracellular glutamateInterictal electroencephalographyMicrodialysis catheterEpilepsy surgeryExtracellular glutamateBrain neurochemistryDialysis probeNeurochemical basisEEG monitoringGlutamate concentrationBrain regionsEpilepsyPatients
2015
Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy
Gruenbaum SE, Wang H, Zaveri HP, Tang AB, Lee TS, Eid T, Dhaher R. Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy. Epilepsy & Behavior 2015, 51: 96-103. PMID: 26262937, PMCID: PMC4663049, DOI: 10.1016/j.yebeh.2015.07.015.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnalysis of VarianceAnhedoniaAnimalsBrainCentral Amygdaloid NucleusComorbidityDepressive DisorderDisease Models, AnimalElectroencephalographyEnzyme InhibitorsEpilepsy, Temporal LobeGlutamate-Ammonia LigaseHippocampusMaleMethionine SulfoximineNeuronsRatsRats, Sprague-DawleySeizuresConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyRecurrent seizuresLobe epilepsyCentral nucleusMale Sprague-Dawley ratsPrevalence of depressionSprague-Dawley ratsGlutamine synthetase inhibitor methionine sulfoximineMeasures of anhedoniaRight CeA.Seizure activityAnhedonic behaviorDentate gyrusMedial amygdalaSucrose preferenceRat modelCommon causeAstrocytic enzymeBasolateral amygdalaLateral amygdalaOsmotic pumpPatientsEpilepsyAmygdala
2013
Intracranial EEG evaluation of relationship within a resting state network
Duncan D, Duckrow RB, Pincus SM, Goncharova I, Hirsch LJ, Spencer DD, Coifman RR, Zaveri HP. Intracranial EEG evaluation of relationship within a resting state network. Clinical Neurophysiology 2013, 124: 1943-1951. PMID: 23790525, DOI: 10.1016/j.clinph.2013.03.028.Peer-Reviewed Original ResearchConceptsDefault mode networkIntracranial EEG evaluationMode networkLocalization-related epilepsyCross-approximate entropyNeuronal involvementHemodynamic measurementsIntracranial EEG recordingsEEG evaluationBackground activityGamma powerFMRI studyIntracranial EEGBrain activityPatientsEEG recordingsLow levelsT2EpilepsyMagnitude squared coherenceT1
2012
Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy
Perez EL, Lauritzen F, Wang Y, Lee TS, Kang D, Zaveri HP, Chaudhry FA, Ottersen OP, Bergersen LH, Eid T. Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy. Neurobiology Of Disease 2012, 47: 331-337. PMID: 22659305, PMCID: PMC3392431, DOI: 10.1016/j.nbd.2012.05.010.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyRecurrent seizuresConcentration of glutamateHippocampal formationLobe epilepsyExtracellular glutamateRefractory temporal lobe epilepsyEpileptogenic hippocampal formationExtracellular brain glutamateSubset of patientsSaline-treated ratsStart of infusionRatio of glutamateExcessive glutamateGlutamate excessBrain glutamateExtracellular brainAstrocytesExcessive releaseGS deficiencyRatsSeizuresGlutamateSeparate groupsEpilepsy
2009
Intracranial EEG power and metabolism in human epilepsy
Pan JW, Zaveri HP, Spencer DD, Hetherington HP, Spencer SS. Intracranial EEG power and metabolism in human epilepsy. Epilepsy Research 2009, 87: 18-24. PMID: 19699059, PMCID: PMC2783857, DOI: 10.1016/j.eplepsyres.2009.07.006.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyNAA/CrMesial temporal lobeNeocortical epilepsySeizure onset zoneN-acetyl aspartateHigh-frequency activityTemporal lobeOnset zoneFrequency activityMetabolic imagingIntracranial EEG analysisTemporal lobe epilepsyEEG powerQuantitative EEG measuresLobe epilepsySame anatomical regionMTLE groupSeizure localizationHuman epilepsyTissue injuryEpilepsy patientsHuman studiesAbnormal manifestationsEpilepsySpatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsies
Goncharova II, Zaveri HP, Duckrow RB, Novotny EJ, Spencer SS. Spatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsies. Epilepsia 2009, 50: 2575-2585. PMID: 19674048, DOI: 10.1111/j.1528-1167.2009.02258.x.Peer-Reviewed Original ResearchConceptsMedial temporal structuresInterictal spikesLT patientsCortical areasNeocortical seizure onsetsSleep-related increaseSpike rateLateral temporal epilepsyExtratemporal areasTemporal epilepsySeizure onsetIntracranial monitoringLT groupMT groupPatientsFrontal spikesSeizuresGreater numberSleepGroupTemporal structureEpilepsySpikesLocalization-related epilepsy exhibits significant connectivity away from the seizure-onset area
Zaveri HP, Pincus SM, Goncharova II, Duckrow RB, Spencer DD, Spencer SS. Localization-related epilepsy exhibits significant connectivity away from the seizure-onset area. Neuroreport 2009, 20: 891-895. PMID: 19424095, DOI: 10.1097/wnr.0b013e32832c78e0.Peer-Reviewed Original ResearchConceptsSeizure onset areaLocalization-related epilepsyControl of seizuresDiscrete cortical areasStandard clinical proceduresBeta frequency bandsUnselected patientsComplete resectionEpilepsy surgeryCortical areasFunctional connectivitySeizuresClinical proceduresEpilepsyIntracranial electroencephalogramSignificant connectivityResectionPatientsSurgeryIMAGING | Physiologic Correlates of Metabolic Imaging in Human Epilepsy
Pan J, Williamson A, Cavus I, Zaveri H, Spencer D, Hetherington H. IMAGING | Physiologic Correlates of Metabolic Imaging in Human Epilepsy. 2009, 1568-1573. DOI: 10.1016/b978-012373961-2.00222-8.Peer-Reviewed Original ResearchHuman epilepsyNAA/Cr ratioMetabolic imagingPCr/ATP ratioLocalization/lateralizationMR spectroscopic studiesEpileptic hippocampusMicrodialysis measuresPathophysiologic correlatesSeizure focusNeuropsychologic dataExtracellular glutamateMetabolic dysfunctionMetabolic pathophysiologyVivo MR spectroscopyElectrophysiological functionPhysiologic correlatesEpilepsyMR spectroscopic measurementsMR spectroscopyCr ratioMitochondrial functionMR spectroscopicMemory functionHuman brain