2024
Improvement in coping skills from culturally-adapted digital CBT for Spanish-speaking Hispanics with substance use disorder: Secondary analysis of a randomized clinical trial
Benitez B, Loya J, Jaramillo Y, Muro-Rodriguez N, Rojas Perez O, Nich C, Frankforter T, Paris M, Kiluk B. Improvement in coping skills from culturally-adapted digital CBT for Spanish-speaking Hispanics with substance use disorder: Secondary analysis of a randomized clinical trial. Journal Of Substance Use And Addiction Treatment 2024, 168: 209536. PMID: 39374899, DOI: 10.1016/j.josat.2024.209536.Peer-Reviewed Original ResearchMechanisms of cognitive behavioral therapyQuality of coping skillsCognitive behavioral therapySubstance use disordersPrimary substance useCoping skillsSubstance useCBT programOutpatient treatmentWeeks of outpatient treatmentDigital cognitive behavioral therapyMechanisms of behavior changeWithin-person increasesDaily substance useAdaptive coping skillsSecondary analysis of clinical trial dataTreatment mechanismsRandomized to 8Associated with reductionsBehavioral therapyAnalysis of clinical trial dataUse disorderGeneralizability of researchSecondary analysisSpanish-speaking Hispanic adultsA Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder
Kiluk B, Benitez B, DeVito E, Frankforter T, LaPaglia D, O’Malley S, Nich C. A Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder. JAMA Network Open 2024, 7: e2435205. PMID: 39325452, PMCID: PMC11428014, DOI: 10.1001/jamanetworkopen.2024.35205.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyDigital cognitive behavioral therapyAlcohol use disorderAlcohol useCBT programUse disorderCognitive behavioral therapy programCurrent alcohol use disorderTreatment-seeking adultsBehavioral therapy programEvidence-based treatmentsBaseline to 6-month follow-upRates of alcohol useReducing alcohol useTreatment periodRandomized clinical trialsBehavioral therapyOutpatient substancePercentage of daysOutpatient treatmentIntention-to-treat analysisIndividual counselingStudy periodFollow-upIntention-to-treatFrom alcohol and other drug treatment mediator to mechanism to implementation: A systematic review and the cases of self‐efficacy, social support, and craving
Maisto S, Moskal D, Firkey M, Bergman B, Borsari B, Hallgren K, Houck J, Hurlocker M, Kiluk B, Kuerbis A, Reid A, Magill M. From alcohol and other drug treatment mediator to mechanism to implementation: A systematic review and the cases of self‐efficacy, social support, and craving. Alcohol Clinical And Experimental Research 2024, 48: 1677-1692. PMID: 39182214, DOI: 10.1111/acer.15411.Peer-Reviewed Original ResearchMechanisms of behavior changeSelf-efficacySocial supportAdult samplesEmpirical supportAOD treatmentCase of self-efficacyCravingSystematic review of empirical studiesReview of empirical studiesBehavioral changesDrug useTreatment mechanismsKazdinClinical practiceSystematic reviewNockSystematic review of reviewsResearch evidenceTreatment effectsMeta-analysesAlcoholReview of reviewsPreferred Reporting ItemsMediatorsMeasurement invariance of the Perceived Stress Scale across race, sex, and time, and differential impacts on cocaine use treatment outcomes
Schick M, Kiluk B, Nich C, LaPaglia D, Haeny A. Measurement invariance of the Perceived Stress Scale across race, sex, and time, and differential impacts on cocaine use treatment outcomes. Journal Of Substance Use And Addiction Treatment 2024, 166: 209493. PMID: 39151798, PMCID: PMC11392621, DOI: 10.1016/j.josat.2024.209493.Peer-Reviewed Original ResearchCocaine use disorderPerceived Stress ScaleTreatment retentionMeasurement invarianceTreatment outcomesSubstance use treatment outcomesStress ScalePredicting treatment retentionSelf-efficacyCoping self-efficacyTwo-factor modelInfluence treatment outcomeCocaine abuse/dependenceDSM-IVUse disorderCocaine useBetween-group differencesMetric invarianceScalar invarianceTwo-factorCocainePharmacological treatmentFactor analysisDifferential impactAbuse/dependenceA smartphone app-based mindfulness intervention to enhance recovery from substance use disorders: Protocol for a pilot feasibility randomized controlled trial
Roos C, Bricker J, Kiluk B, Trull T, Bowen S, Witkiewitz K, Kober H. A smartphone app-based mindfulness intervention to enhance recovery from substance use disorders: Protocol for a pilot feasibility randomized controlled trial. Contemporary Clinical Trials Communications 2024, 41: 101338. PMID: 39233850, PMCID: PMC11372603, DOI: 10.1016/j.conctc.2024.101338.Peer-Reviewed Original ResearchTreatment-as-usualSubstance use disordersRecovery outcomesLong-term recovery outcomesFeasibility of study proceduresFeasibility randomized controlled trialMindfulness-based treatmentsUse disorderRandomized controlled trialsEcological momentary assessmentIn-personMindfulness interventionPilot trialStudy proceduresControlled trialsMomentary assessmentPublic healthEnhanced recoveryOutpatient treatmentMechanical variablesOutcomesTrialsAppsDelivery methodsIndividualsT166 Treatment Outcomes From Computerized CBT for Substance Use Disorders Among People With Criminal Justice Involvement
Loya J, Babuscio T, Nich C, Kiluk B. T166 Treatment Outcomes From Computerized CBT for Substance Use Disorders Among People With Criminal Justice Involvement. Drug And Alcohol Dependence 2024, 260: 110615. DOI: 10.1016/j.drugalcdep.2023.110615.Peer-Reviewed Original ResearchA Descriptive Review and Meta-Regression Study of Demographic and Study Context Factors in US Clinical Trials of Cognitive Behavioral Interventions for Alcohol or Other Drug Use
Burnett D, Trikalinos T, Kiluk B, Ray L, Misquith C, Magill M. A Descriptive Review and Meta-Regression Study of Demographic and Study Context Factors in US Clinical Trials of Cognitive Behavioral Interventions for Alcohol or Other Drug Use. Substance Use & Misuse 2024, 59: 1711-1721. PMID: 38946162, PMCID: PMC11421968, DOI: 10.1080/10826084.2024.2369167.Peer-Reviewed Original ResearchBetween-condition effect sizeStudy-level moderatorsCognitive behavioral interventionSubstance use outcomesEvidence-based treatmentsBetween-condition effectsMental health conditionsCognitive-behavioralBehavioral interventionsEffect sizeBiological sexContext factorsStudy publication dateDrug useParticipant ageSexual orientationTreatment effectsStandardized mean differenceModeratelyAlcoholClinical trialsPreliminary dataPopulation sub-groupsHealth conditionsAODStructural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment
McCurdy L, DeVito E, Loya J, Nich C, Zhai Z, Kiluk B, Potenza M. Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment. Drug And Alcohol Dependence Reports 2024, 11: 100246. PMID: 38966567, PMCID: PMC11222934, DOI: 10.1016/j.dadr.2024.100246.Peer-Reviewed Original ResearchCocaine use disorderCognitive behavioral therapyCocaine useBehavioral therapyBrain changesBrain structuresWhole-brain voxel-based morphometry analysisCocaine use disorder treatmentLevel of cocaine useWeeks of outpatient treatmentVoxel-based morphometry analysisDigital cognitive behavioral therapyT1-weighted magnetic resonance imaging scansRight caudate bodyAssociated with cocaine useMethadone-maintained individualsGray matter volumeStructural brain changesFunction of engagementCaudate bodyRight caudateCUD treatmentMatter volumeUse disorderBilateral cerebellumExamining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence
Votaw V, Tuchman F, Roos C, Hebden H, McKay J, Kiluk B, Witkiewitz K. Examining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence. Journal Of Substance Use And Addiction Treatment 2024, 163: 209394. PMID: 38735481, PMCID: PMC11180556, DOI: 10.1016/j.josat.2024.209394.Peer-Reviewed Original ResearchCocaine use disorderCocaine useAssociated with less cocaine useTelephone-based continuing careLevel of cocaine useFollow-upDrug use consequencesAssociated with lower levelsClinical trialsBaseline to 12-month follow-upCocaine dependenceTreatment entryProblem severityUse disorderTimeline FollowbackCocaineInitial treatment phaseAbstinenceLow-frequency useLong-term functional outcomeEffect sizeTreatment phaseLong-term outcomesRandomized clinical trialsNegative consequencesUnderstanding the patient and supporter journey in cocaine use disorder
Leclair D, Waye K, Gomez-Mancilla B, Kiluk B, Karanam A, Banerjee P, Muthusamy V, Maahs S. Understanding the patient and supporter journey in cocaine use disorder. Frontiers In Psychiatry 2024, 15: 1230626. PMID: 38659460, PMCID: PMC11040082, DOI: 10.3389/fpsyt.2024.1230626.Peer-Reviewed Original ResearchPatient perspectives on current and potential therapies and clinical trial approaches for cocaine use disorder
Maahs S, Leclair D, Gomez-Mancilla B, Kiluk B, Muthusamy V, Banerjee P, Dasgupta S, Waye K. Patient perspectives on current and potential therapies and clinical trial approaches for cocaine use disorder. Frontiers In Psychiatry 2024, 15: 1230699. PMID: 38487570, PMCID: PMC10937549, DOI: 10.3389/fpsyt.2024.1230699.Peer-Reviewed Original ResearchCocaine use disorderLong-term abstinenceSubstance use disordersBarriers to therapyWithdrawal symptomsUse disorderCraving controlClinical trialsCocaineClinical trial approachesDesign of clinical trialsCravingScreening questionnaireDisordersClinical trial outcomesTrial outcomesPerspectives of individualsRemissionParticipantsDrug seekersPotential therapiesTherapyIndividualsRecruited participantsAbstinenceDevelopment and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder
Roos C, Kiluk B, Carroll K, Bricker J, Mun C, Sala M, Kirouac M, Stein E, John M, Palmer R, DeBenedictis A, Frisbie J, Haeny A, Barry D, Fucito L, Bowen S, Witkiewitz K, Kober H. Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder. Annals Of Medicine 2024, 56: 2315228. PMID: 38382111, PMCID: PMC10883107, DOI: 10.1080/07853890.2024.2315228.Peer-Reviewed Original ResearchConceptsSubstance use disordersMindfulness-based interventionsPhone coachingQualitative feedbackPromote recoveryEvidence of feasibilityUse disorderPhase 2Promote long-term recoveryApp featuresUnmet needsAdjunctive interventionTen adultsSmartphone appLong-term recoveryInterventionTherapy videosMindfulness practiceParticipantsOutpatient treatmentMind toolPhase 1CoachingAcceptance dimensionQuantitative ratings
2023
A non-randomized pilot study protocol of a novel social support intervention for individuals in early recovery from hazardous alcohol use
McCurdy L, Kong G, Krishnan-Sarin S, Kiluk B, Potenza M. A non-randomized pilot study protocol of a novel social support intervention for individuals in early recovery from hazardous alcohol use. PLOS ONE 2023, 18: e0292293. PMID: 37796784, PMCID: PMC10553253, DOI: 10.1371/journal.pone.0292293.Peer-Reviewed Original ResearchConceptsRecovery support servicesHazardous alcohol useSocial support interventionsAlcohol usePilot studyEarly recoverySupport interventionsPilot study protocolMixed methods pilot studyOnline social support interventionQuality of lifeSupport servicesSelf-reported changesPrimary outcomeSecondary outcomesStudy protocolHazardous alcoholThe connection still matters: Therapeutic alliance with digital treatment for alcohol use disorder
Benitez B, Frankforter T, Nich C, Kiluk B. The connection still matters: Therapeutic alliance with digital treatment for alcohol use disorder. Alcohol Clinical And Experimental Research 2023, 47: 2197-2207. PMID: 38226756, PMCID: PMC10792249, DOI: 10.1111/acer.15199.Peer-Reviewed Original ResearchWorking Alliance InventoryAlliance ratingsAlcohol useMinimal clinical monitoringOutpatient AUD treatmentPatient-reported measuresAlcohol use disorderDisorder treatment outcomesDaily alcohol useCognitive behavioral therapy programBehavioral therapy programAlcohol use disorder treatment outcomesClinical trialsTreatment outcomesFuture drinkingUse disordersTreatment efficacyTreatment sessionsAUD treatmentClinical monitoringComputerized cognitive behavioural therapy programmeTherapy programFuture alcohol useTherapeutic allianceAlliance InventoryDistinct neural networks predict cocaine versus cannabis treatment outcomes
Lichenstein S, Kohler R, Ye F, Potenza M, Kiluk B, Yip S. Distinct neural networks predict cocaine versus cannabis treatment outcomes. Molecular Psychiatry 2023, 28: 3365-3372. PMID: 37308679, PMCID: PMC10713861, DOI: 10.1038/s41380-023-02120-0.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingCognitive behavior therapyCognitive behavioral therapySubstance use disordersCannabis abstinenceNeural mechanismsBehavior therapyDistinct neural networksComputer-based trainingCannabis use disorderFMRI scanningNeural predictorsStudy 1Study 2Treatment outcomesContingency managementPrior workComparison subjectsNetwork strengthUse disordersNovel treatment targetsAbstinenceIndependent samplesCocaine abstinenceTreatment respondersPercentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use
Loya J, Babuscio T, Nich C, Alessi S, Rash C, Kiluk B. Percentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use. Drug And Alcohol Dependence 2023, 248: 109947. PMID: 37276806, PMCID: PMC10498479, DOI: 10.1016/j.drugalcdep.2023.109947.Peer-Reviewed Original ResearchConceptsUrine drug screensClinical trialsMeaningful endpointsCocaine useLong-term clinical benefitBetter long-term outcomesDrug screensPsychosocial functioningNegative urine drug screensLong-term outcomesRandomized clinical trialsFuture clinical trialsBetter psychosocial functioningClinical benefitPharmacological treatmentContinuous abstinenceTreatment periodTreatment respondersSustained abstinenceSubstance useTrialsTreatmentMeaningful thresholdPooled datasetAbstinenceThe Effect of Cognitive Behavioral Therapy on Impulsivity in Addictive Disorders: a Narrative Review
Loya J, Benitez B, Kiluk B. The Effect of Cognitive Behavioral Therapy on Impulsivity in Addictive Disorders: a Narrative Review. Current Addiction Reports 2023, 10: 485-493. PMID: 38269068, PMCID: PMC10805411, DOI: 10.1007/s40429-023-00491-6.Peer-Reviewed Original ResearchCognitive behavioral therapyBehavioral therapySubstance useAddictive disordersFuture clinical trialsPoor treatment outcomesEvidence-based treatmentsMeasures of impulsivityCycle of addictionCBT effectsRisk factorsClinical trialsTreatment outcomesRecent FindingsThereNarrative reviewCharacteristics of addictionLimited evidenceRange of addictionsAssessment of impulsivityTherapyAddictionTrialsDisordersImpulsivityAddictive behaviorsSmartphone Apps for Problem Gambling: a Review of Content and Quality
McCurdy L, Loya J, Hart-Derrick V, Young G, Kiluk B, Potenza M. Smartphone Apps for Problem Gambling: a Review of Content and Quality. Current Addiction Reports 2023, 10: 178-186. PMID: 38463534, PMCID: PMC10919356, DOI: 10.1007/s40429-023-00479-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements42. Identification and External Validation of a Problem Cannabis Use Neural Network
Lichenstein S, Scheinost D, Kiluk B, Carroll K, Potenza M, Pearlson G, Yip S. 42. Identification and External Validation of a Problem Cannabis Use Neural Network. Biological Psychiatry 2023, 93: s87. DOI: 10.1016/j.biopsych.2023.02.225.Peer-Reviewed Original ResearchAddictions treatment mechanisms of change science and implementation science: A critical review
Magill M, Maisto S, Borsari B, Glass J, Hallgren K, Houck J, Kiluk B, Kuerbis A. Addictions treatment mechanisms of change science and implementation science: A critical review. Alcohol Clinical And Experimental Research 2023, 47: 827-839. PMID: 36913967, PMCID: PMC10314994, DOI: 10.1111/acer.15053.Peer-Reviewed Original Research