Annexin-A5 monomer as a membrane repair agent for the treatment of renal ischemia-reperfusion injury
Dong Y, Jia Z, Kang B, Zhang W. Annexin-A5 monomer as a membrane repair agent for the treatment of renal ischemia-reperfusion injury. Molecular Biology Reports 2024, 51: 679. PMID: 38796668, DOI: 10.1007/s11033-024-09606-2.Peer-Reviewed Original ResearchConceptsRenal ischemia-reperfusion injuryIschemia-reperfusion injuryEffect of anxA5Bilateral renal IRIBackgroundRenal ischemia-reperfusion injuryProtective effectTreatment of renal ischemia-reperfusion injuryAcute kidney injurySimulated ischemia-reperfusion injuryEpithelial cell membranesHK-2 cellsMechanism of actionKidney injurySD ratsIn vitro experimentsTherapeutic effectPrevent cell deathMeasure cellular activityKidney structureAnnexin A5HK-2AnxA5In vitroCell deathCell membrane integrityAnnexin A5 Derived from Cell-free Fat Extract Attenuates Osteoarthritis via Macrophage Regulation
Jia Z, Kang B, Dong Y, Fan M, Li W, Zhang W. Annexin A5 Derived from Cell-free Fat Extract Attenuates Osteoarthritis via Macrophage Regulation. International Journal Of Biological Sciences 2024, 20: 2994-3007. PMID: 38904008, PMCID: PMC11186356, DOI: 10.7150/ijbs.92802.Peer-Reviewed Original ResearchConceptsCell-free fat extractToll-like receptorsChondrocyte viabilityMacrophage polarizationOsteoarthritis rat modelChondrocyte necrosisRegulating macrophage polarizationAnnexin A5Pro-inflammatory mediator releaseCartilage damageInhibiting M1 macrophage polarizationChondrocytesM1 macrophage polarizationPain symptomsTherapeutic optionsMediator releaseRat modelTLR4 expressionMacrophage regulationProduction of reactive oxygen speciesIntra-articular administrationHistological analysisManagement of OAPolarizationAnxA5