Annexin-A5 monomer as a membrane repair agent for the treatment of renal ischemia-reperfusion injury
Dong Y, Jia Z, Kang B, Zhang W. Annexin-A5 monomer as a membrane repair agent for the treatment of renal ischemia-reperfusion injury. Molecular Biology Reports 2024, 51: 679. PMID: 38796668, DOI: 10.1007/s11033-024-09606-2.Peer-Reviewed Original ResearchConceptsRenal ischemia-reperfusion injuryIschemia-reperfusion injuryEffect of anxA5Bilateral renal IRIBackgroundRenal ischemia-reperfusion injuryProtective effectTreatment of renal ischemia-reperfusion injuryAcute kidney injurySimulated ischemia-reperfusion injuryEpithelial cell membranesHK-2 cellsMechanism of actionKidney injurySD ratsIn vitro experimentsTherapeutic effectPrevent cell deathMeasure cellular activityKidney structureAnnexin A5HK-2AnxA5In vitroCell deathCell membrane integrityCell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy
Sun Y, Chen D, Dai T, Yu Z, Xie H, Wang X, Zhang W. Cell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy. Frontiers In Cellular Neuroscience 2024, 18: 1344853. PMID: 38515790, PMCID: PMC10954833, DOI: 10.3389/fncel.2024.1344853.Peer-Reviewed Original ResearchCell-free fat extractRate of retinal ganglion cellsEnzyme-linked immunosorbent assayCentral nervous systemOptic nerve crushSurvival rate of retinal ganglion cellsTherapeutic effectRetinal ganglion cell survivalInflammatory factorsAxonal regenerationTraumatic optic neuropathyGanglion cell survivalWestern blottingStaining of microgliaGene OntologyCentral nervous system injuryLevels of inflammatory factorsRetinal ganglion cellsOptic neuropathyWeeks post-injuryComprehensive gene ontologyOptic nerveNerve crushRetinal tissueClinical challenge