2024
Cell-Free Fat Extract with Anti-melanogenic Property Improves the Appearance of Infraorbital Dark Circles: A Preliminary Clinical Study
Kang B, Cai Y, Jia Z, Yao L, Gu J, Li W, Zhang W. Cell-Free Fat Extract with Anti-melanogenic Property Improves the Appearance of Infraorbital Dark Circles: A Preliminary Clinical Study. Aesthetic Plastic Surgery 2024, 1-10. PMID: 39532743, DOI: 10.1007/s00266-024-04445-9.Peer-Reviewed Original ResearchCell-free fat extractInfraorbital dark circlesDark circlesFollow-upLevel of Evidence IVThis journalEvidence-Based Medicine ratingsPreliminary clinical studiesLevel of evidenceStatistically significant improvementIVThis journalClinical studiesIntradermal injectionClinical trialsPeriocular wrinklesClinical trial assessmentEvaluation of skin colorEffective treatmentMelanin contentConclusionOur studyPatientsTreatmentInhibited melanin synthesisOnline InstructionsZebrafish embryosSignificant improvementAnnexin A5 Derived from Cell-free Fat Extract Attenuates Osteoarthritis via Macrophage Regulation
Jia Z, Kang B, Dong Y, Fan M, Li W, Zhang W. Annexin A5 Derived from Cell-free Fat Extract Attenuates Osteoarthritis via Macrophage Regulation. International Journal Of Biological Sciences 2024, 20: 2994-3007. PMID: 38904008, PMCID: PMC11186356, DOI: 10.7150/ijbs.92802.Peer-Reviewed Original ResearchConceptsCell-free fat extractToll-like receptorsChondrocyte viabilityMacrophage polarizationOsteoarthritis rat modelChondrocyte necrosisRegulating macrophage polarizationAnnexin A5Pro-inflammatory mediator releaseCartilage damageInhibiting M1 macrophage polarizationChondrocytesM1 macrophage polarizationPain symptomsTherapeutic optionsMediator releaseRat modelTLR4 expressionMacrophage regulationProduction of reactive oxygen speciesIntra-articular administrationHistological analysisManagement of OAPolarizationAnxA5Recombinant human annexin A5 accelerates diabetic wounds healing by regulating skin inflammation
Kang B, Jia Z, Dong Y, Li W, Zhang W. Recombinant human annexin A5 accelerates diabetic wounds healing by regulating skin inflammation. Regenerative Therapy 2024, 27: 342-353. PMID: 38645281, PMCID: PMC11031805, DOI: 10.1016/j.reth.2024.03.013.Peer-Reviewed Original ResearchCell-free fat extractAnnexin A5Regulator of macrophage inflammationEpithelial cellsDiabetic wound healingHealing of diabetic woundsPromotion of epithelializationDiabetic woundsHuman annexin A5Anti-CD68 stainingWound healingAnti-inflammatory proteinReduced pro-inflammatory factorsRegulating skin inflammationMigration of epithelial cellsAnti-CD86Pro-inflammatory factorsPolarization of macrophagesQRT-PCRCell migration assayM1 to M2 phenotypeActive inflammationEpithelial regulationSkin inflammationTransition of macrophagesCell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy
Sun Y, Chen D, Dai T, Yu Z, Xie H, Wang X, Zhang W. Cell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy. Frontiers In Cellular Neuroscience 2024, 18: 1344853. PMID: 38515790, PMCID: PMC10954833, DOI: 10.3389/fncel.2024.1344853.Peer-Reviewed Original ResearchCell-free fat extractRate of retinal ganglion cellsEnzyme-linked immunosorbent assayCentral nervous systemOptic nerve crushSurvival rate of retinal ganglion cellsTherapeutic effectRetinal ganglion cell survivalInflammatory factorsAxonal regenerationTraumatic optic neuropathyGanglion cell survivalWestern blottingStaining of microgliaGene OntologyCentral nervous system injuryLevels of inflammatory factorsRetinal ganglion cellsOptic neuropathyWeeks post-injuryComprehensive gene ontologyOptic nerveNerve crushRetinal tissueClinical challengePro-vasculogenic Fibers by PDA-Mediated Surface Functionalization Using Cell-Free Fat Extract (CEFFE)
Li D, Li Q, Xu T, Guo X, Tang H, Wang W, Zhang W, Zhang Y. Pro-vasculogenic Fibers by PDA-Mediated Surface Functionalization Using Cell-Free Fat Extract (CEFFE). Biomacromolecules 2024, 25: 1550-1562. PMID: 38411008, DOI: 10.1021/acs.biomac.3c01124.Peer-Reviewed Original ResearchConceptsFunctional biomaterial scaffoldsFunctional electrospun fibersFunctional tissue regenerationEngineered three-dimensionalTissue regenerationFibrous scaffoldsElectrospun fibersBiomaterial scaffoldsFiber surfaceBiomaterial constructsSurface functionalizationPCL/GTThree-dimensionalAdequate vascular networkPolydopamineFibersScaffoldsSustained mannerBioactive agentsCytocompatibilityVascular networkCell-free fat extract
2023
Intradermal Local Injection of Autologous Cell‐Free Fat Extract for the Treatment of Refractory Postinflammatory Hyperpigmentation
Cai Y, Jia Z, Gu J, Kang B, Zheng H, Li W, Zhang W. Intradermal Local Injection of Autologous Cell‐Free Fat Extract for the Treatment of Refractory Postinflammatory Hyperpigmentation. Dermatologic Therapy 2023, 2023 DOI: 10.1155/2023/9561809.Peer-Reviewed Original ResearchCell-free fat extractTreatment of PIHPostinflammatory hyperpigmentationTreatment-related adverse eventsMonths of treatmentCurrent treatment modalitiesTransepidermal water lossAdverse eventsSerious complicationsTreatment modalitiesIntradermal injectionLocal injectionEfficacy assessmentFat extractTwo-week intervalsPatientsLesion colorSubjective parametersTreatmentSignificant reductionHyperpigmentationInjectionBS indexSkin lightnessSignificant improvement