Annexin-A5 monomer as a membrane repair agent for the treatment of renal ischemia-reperfusion injury
Dong Y, Jia Z, Kang B, Zhang W. Annexin-A5 monomer as a membrane repair agent for the treatment of renal ischemia-reperfusion injury. Molecular Biology Reports 2024, 51: 679. PMID: 38796668, DOI: 10.1007/s11033-024-09606-2.Peer-Reviewed Original ResearchConceptsRenal ischemia-reperfusion injuryIschemia-reperfusion injuryEffect of anxA5Bilateral renal IRIBackgroundRenal ischemia-reperfusion injuryProtective effectTreatment of renal ischemia-reperfusion injuryAcute kidney injurySimulated ischemia-reperfusion injuryEpithelial cell membranesHK-2 cellsMechanism of actionKidney injurySD ratsIn vitro experimentsTherapeutic effectPrevent cell deathMeasure cellular activityKidney structureAnnexin A5HK-2AnxA5In vitroCell deathCell membrane integrityAnnexin A5 Derived from Cell-free Fat Extract Attenuates Osteoarthritis via Macrophage Regulation
Jia Z, Kang B, Dong Y, Fan M, Li W, Zhang W. Annexin A5 Derived from Cell-free Fat Extract Attenuates Osteoarthritis via Macrophage Regulation. International Journal Of Biological Sciences 2024, 20: 2994-3007. PMID: 38904008, PMCID: PMC11186356, DOI: 10.7150/ijbs.92802.Peer-Reviewed Original ResearchConceptsCell-free fat extractToll-like receptorsChondrocyte viabilityMacrophage polarizationOsteoarthritis rat modelChondrocyte necrosisRegulating macrophage polarizationAnnexin A5Pro-inflammatory mediator releaseCartilage damageInhibiting M1 macrophage polarizationChondrocytesM1 macrophage polarizationPain symptomsTherapeutic optionsMediator releaseRat modelTLR4 expressionMacrophage regulationProduction of reactive oxygen speciesIntra-articular administrationHistological analysisManagement of OAPolarizationAnxA5Recombinant human annexin A5 accelerates diabetic wounds healing by regulating skin inflammation
Kang B, Jia Z, Dong Y, Li W, Zhang W. Recombinant human annexin A5 accelerates diabetic wounds healing by regulating skin inflammation. Regenerative Therapy 2024, 27: 342-353. PMID: 38645281, PMCID: PMC11031805, DOI: 10.1016/j.reth.2024.03.013.Peer-Reviewed Original ResearchCell-free fat extractAnnexin A5Regulator of macrophage inflammationEpithelial cellsDiabetic wound healingHealing of diabetic woundsPromotion of epithelializationDiabetic woundsHuman annexin A5Anti-CD68 stainingWound healingAnti-inflammatory proteinReduced pro-inflammatory factorsRegulating skin inflammationMigration of epithelial cellsAnti-CD86Pro-inflammatory factorsPolarization of macrophagesQRT-PCRCell migration assayM1 to M2 phenotypeActive inflammationEpithelial regulationSkin inflammationTransition of macrophages