2011
The impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers
Chen Z, Roberts K, Decker R, Pathare P, Rockwell S, Nath R. The impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers. Physics In Medicine And Biology 2011, 56: 4895-4912. PMID: 21772076, PMCID: PMC3154133, DOI: 10.1088/0031-9155/56/15/016.Peer-Reviewed Original ResearchConceptsPermanent interstitial brachytherapyProstate edemaProstate cancerEffects of edemaTumor control probabilityImpact of edemaInterstitial brachytherapyCell survivalEarly-stage prostate cancerControl probabilityStage prostate cancerCurrent clinical practiceProstate cancer cellsTumor cell proliferationInterstitial brachytherapy treatmentSublethal damage repairDose variationTumor cell survivalTumor characteristicsTumor controlClinical impactEdemaEdema evolutionClinical practiceProstate gland
2010
A systematic evaluation of the dose-rate constant determined by photon spectrometry for 21 different models of low-energy photon-emitting brachytherapy sources
Chen Z, Nath R. A systematic evaluation of the dose-rate constant determined by photon spectrometry for 21 different models of low-energy photon-emitting brachytherapy sources. Physics In Medicine And Biology 2010, 55: 6089-6104. PMID: 20871136, PMCID: PMC3265933, DOI: 10.1088/0031-9155/55/20/004.Peer-Reviewed Original ResearchResponse to “Comment on ‘AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137’” [Med. Phys. 36, 5310–5322 (2009)]
Nath R, Bice WS, Butler WM, Chen Z, Meigooni AS, Narayana V, Rivard MJ, Yu Y. Response to “Comment on ‘AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137’” [Med. Phys. 36, 5310–5322 (2009)]. Medical Physics 2010, 37: 1933-1933. PMID: 20443515, DOI: 10.1118/1.3358143.Peer-Reviewed Original ResearchA photon spectrometric dose‐rate constant determination for the Advantage™ Pd‐103 brachytherapy source
Chen ZJ, Bongiorni P, Nath R. A photon spectrometric dose‐rate constant determination for the Advantage™ Pd‐103 brachytherapy source. Medical Physics 2010, 37: 672-674. PMID: 20229876, PMCID: PMC2821420, DOI: 10.1118/1.3298011.Peer-Reviewed Original Research
2009
Time dependence of energy spectra of brachytherapy sources and its impact on the half and the tenth value layers
Yue NJ, Chen Z, Hearn RA, Rodgers JJ, Nath R. Time dependence of energy spectra of brachytherapy sources and its impact on the half and the tenth value layers. Medical Physics 2009, 36: 5175-5182. PMID: 19994527, DOI: 10.1118/1.3246843.Peer-Reviewed Original Research
2008
Photon energy spectrum emitted by a novel polymer‐encapsulated source and its effect on the dose rate constant
Khan S, Chen ZJ, Nath R. Photon energy spectrum emitted by a novel polymer‐encapsulated source and its effect on the dose rate constant. Medical Physics 2008, 35: 1403-1406. PMID: 18491535, PMCID: PMC2673625, DOI: 10.1118/1.2870231.Peer-Reviewed Original Research
2005
Relative Biological Effectiveness of 103Pd and 125I Photons for Continuous Low-Dose-Rate Irradiation of Chinese Hamster Cells
Nath R, Bongiorni P, Chen Z, Gragnano J, Rockwell S. Relative Biological Effectiveness of 103Pd and 125I Photons for Continuous Low-Dose-Rate Irradiation of Chinese Hamster Cells. Radiation Research 2005, 163: 501-509. PMID: 15850411, DOI: 10.1667/rr3363.Peer-Reviewed Original ResearchConceptsContinuous low doseRate irradiationDose-rate effectInverse dose-rate effectCGy/hInitial dose rateChinese hamster lung cellsHigher initial dose rateLow doseHamster lung cellsLung cellsDose rateCell survivalX-ray beamRelative biological effectivenessChinese hamster cellsCellsImplantsAverage RBEHamster cellsBiological responsesBiological effectivenessMonoenergetic X-ray beamDose rate dependence of the relative biological effectiveness of 103Pd for continuous low dose rate irradiation of BA1112 rhabdomyosarcoma cells in vitro relative to acute exposures
Nath R, Bongiorni P, Chen Z, Gragnano J, Rockwell S. Dose rate dependence of the relative biological effectiveness of 103Pd for continuous low dose rate irradiation of BA1112 rhabdomyosarcoma cells in vitro relative to acute exposures. International Journal Of Radiation Biology 2005, 81: 689-699. PMID: 16368647, DOI: 10.1080/09553000500401551.Peer-Reviewed Original ResearchConceptsContinuous low dose rate irradiationDose rate irradiationLow dose rate irradiationRate irradiationInterstitial brachytherapyHigh dose rate irradiationAcute exposureRhabdomyosarcoma cellsPermanent interstitial brachytherapyRelative biological effectivenessBA1112 tumorsSame dose rateSurvival curvesHigh linear energy transferAcute irradiationTumor cellsCell survival curvesBiological effectivenessLow dose rateDose-rate effectDose rateBrachytherapy
2004
Iodine 125 Versus Palladium 103 Implants for Prostate Cancer
Peschel RE, Colberg JW, Chen Z, Nath R, Wilson LD. Iodine 125 Versus Palladium 103 Implants for Prostate Cancer. The Cancer Journal 2004, 10: 170-174. PMID: 15285926, DOI: 10.1097/00130404-200405000-00006.Peer-Reviewed Original ResearchConceptsExternal beam radiation therapyMinimum tumor doseDisease-free survival ratesComplication rateTumor doseProstate cancerRadiation therapyClinical outcomesPrognostic groupsBiochemical disease-free survival ratesSurvival rateBiochemical disease-free survivalDisease-free survivalHigh complication ratePoor prognostic groupProstate-specific antigenHormonal therapyT stageGleason scoreSingle institutionTransperineal implantationFavorable groupGrade 3Treatment groupsPatientsDevelopment of a rat solid tumor model for continuous low-dose-rate irradiation studies using 125I and 103Pd sources
Nath R, Bongiorni P, Chen Z, Gragnano J, Rockwell S. Development of a rat solid tumor model for continuous low-dose-rate irradiation studies using 125I and 103Pd sources. Brachytherapy 2004, 3: 159-172. PMID: 15533809, DOI: 10.1016/j.brachy.2004.08.004.Peer-Reviewed Original Research
2003
Biologically effective dose (BED) for interstitial seed implants containing a mixture of radionuclides with different half-lives
Chen Z, Nath R. Biologically effective dose (BED) for interstitial seed implants containing a mixture of radionuclides with different half-lives. International Journal Of Radiation Oncology • Biology • Physics 2003, 55: 825-834. PMID: 12573770, DOI: 10.1016/s0360-3016(02)04282-7.Peer-Reviewed Original Research
2002
Edema-induced increase in tumour cell survival for 125I and 103Pd prostate permanent seed implants—a bio-mathematical model
Yue N, Chen Z, Nath R. Edema-induced increase in tumour cell survival for 125I and 103Pd prostate permanent seed implants—a bio-mathematical model. Physics In Medicine And Biology 2002, 47: 1185-1204. PMID: 11996063, DOI: 10.1088/0031-9155/47/7/313.Peer-Reviewed Original ResearchConceptsTumor potential doubling timeContinuous low dose rate irradiationTumor cell survivalSeed implantsBio-mathematical modelCell survivalExternal beam radiotherapyPresence of edemaProstate seed implantationLow dose rate irradiationEdema magnitudeEffects of edemaPotential doubling timeTypical edemaDose rate irradiationProstate volumeSurgical traumaPermanent seed implantsSeed implantationSignificant edemaTreatment strategiesSurgical proceduresBeam radiotherapyEdemaDose coverage
2001
Dose rate constant and energy spectrum of interstitial brachytherapy sources
Chen Z, Nath R. Dose rate constant and energy spectrum of interstitial brachytherapy sources. Medical Physics 2001, 28: 86-96. PMID: 11213926, DOI: 10.1118/1.1333748.Peer-Reviewed Original Research
2000
Dosimetric effects of edema in permanent prostate seed implants: a rigorous solution
Chen Z, Yue N, Wang X, Roberts K, Peschel R, Nath R. Dosimetric effects of edema in permanent prostate seed implants: a rigorous solution. International Journal Of Radiation Oncology • Biology • Physics 2000, 47: 1405-1419. PMID: 10889396, DOI: 10.1016/s0360-3016(00)00549-6.Peer-Reviewed Original ResearchDosimetric effects of needle divergence in prostate seed implant using and radioactive seeds
Nath S, Chen Z, Yue N, Trumpore S, Peschel R. Dosimetric effects of needle divergence in prostate seed implant using and radioactive seeds. Medical Physics 2000, 27: 1058-1066. PMID: 10841410, DOI: 10.1118/1.598971.Peer-Reviewed Original ResearchConceptsMinimum target doseIodine-125 implantsTarget doseDose coverageTumor biological effective doseTarget dose coverageBiological effective doseBase of prostateRadioactive seedsProstate seed implantsProstate seedPalladium-103Target volumeEffective doseDosimetric qualityDosePatient implantsDosimetric effectsSeed implantsProstateImplantsMagnitude of degradationActual implantationNeedle orientationActual configuration
1999
Optimum timing for image-based dose evaluation of 125I and 103Pd prostate seed implants
Yue N, Chen Z, Peschel R, Dicker A, Waterman F, Nath R. Optimum timing for image-based dose evaluation of 125I and 103Pd prostate seed implants. International Journal Of Radiation Oncology • Biology • Physics 1999, 45: 1063-1072. PMID: 10571216, DOI: 10.1016/s0360-3016(99)00282-5.Peer-Reviewed Original ResearchConceptsDose-volume histogramsProstate volumeDose coverageConventional dose-volume histogramsSeed implantsEdema magnitudeMagnitude of edemaOptimum timingPostimplant dose-volume histogramDose evaluationOptimal patient managementProstate seed implantationPreimplant planImplant patientsPermanent brachytherapy implantsProstate seed implantsPatient managementProstate cancerSeed implantationSurgical proceduresEdemaProstateDose distributionDays postimplantationPatientsLong‐term complications with prostate implants: Iodine‐125 vs. palladium‐103
Peschel R, Chen Z, Roberts K, Nath R. Long‐term complications with prostate implants: Iodine‐125 vs. palladium‐103. International Journal Of Cancer 1999, 7: 278-288. PMID: 10580897, DOI: 10.1002/(sici)1520-6823(1999)7:5<278::aid-roi3>3.0.co;2-3.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisBrachytherapyCell DeathFollow-Up StudiesForecastingHumansIodine RadioisotopesLongitudinal StudiesMaleModels, BiologicalNeoplasm StagingPalladiumProbabilityProstatic NeoplasmsRadioisotopesRadiopharmaceuticalsRadiotherapy DosageRelative Biological EffectivenessRetrospective StudiesTreatment OutcomeConceptsLong-term complicationsMinimum tumor dosesComplication ratePd-103Lower overall complication ratePalladium-103Long-term complication rateIodine-125Overall complication rateHigh complication rateProstate cancer patientsProstate implantsActuarial probabilityGrade IIILog10 cell killCancer patientsVs. 6Tumor dosesClinical practiceCell killProstate cancer brachytherapyEffective doseNormal tissuesPatientsTissue beds