2011
The impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers
Chen Z, Roberts K, Decker R, Pathare P, Rockwell S, Nath R. The impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers. Physics In Medicine And Biology 2011, 56: 4895-4912. PMID: 21772076, PMCID: PMC3154133, DOI: 10.1088/0031-9155/56/15/016.Peer-Reviewed Original ResearchConceptsPermanent interstitial brachytherapyProstate edemaProstate cancerEffects of edemaTumor control probabilityImpact of edemaInterstitial brachytherapyCell survivalEarly-stage prostate cancerControl probabilityStage prostate cancerCurrent clinical practiceProstate cancer cellsTumor cell proliferationInterstitial brachytherapy treatmentSublethal damage repairDose variationTumor cell survivalTumor characteristicsTumor controlClinical impactEdemaEdema evolutionClinical practiceProstate gland
2007
On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy
Chen ZJ, Deng J, Roberts K, Nath R. On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy. International Journal Of Radiation Oncology • Biology • Physics 2007, 70: 303-310. PMID: 17980500, PMCID: PMC2289996, DOI: 10.1016/j.ijrobp.2007.09.007.Peer-Reviewed Original ResearchConceptsDose reductionProstate brachytherapyDose compensationLarge edemaBiochemical recurrence-free survivalRecurrence-free survivalSignificant dose reductionEffects of edemaSublethal damage repairAdditional irradiationPrescription doseProstate cancerIndividual patientsEdemaEdema evolutionPrescribed doseProstate edemaEffective doseRadiobiologic effectsBrachytherapyDoseProstate implantsDose responseImplants
2006
Potential impact of prostate edema on the dosimetry of permanent seed implants using the new (model CS‐1) seeds
Chen Z, Deng J, Roberts K, Nath R. Potential impact of prostate edema on the dosimetry of permanent seed implants using the new (model CS‐1) seeds. Medical Physics 2006, 33: 968-975. PMID: 16696473, DOI: 10.1118/1.2179170.Peer-Reviewed Original Research
2002
Edema-induced increase in tumour cell survival for 125I and 103Pd prostate permanent seed implants—a bio-mathematical model
Yue N, Chen Z, Nath R. Edema-induced increase in tumour cell survival for 125I and 103Pd prostate permanent seed implants—a bio-mathematical model. Physics In Medicine And Biology 2002, 47: 1185-1204. PMID: 11996063, DOI: 10.1088/0031-9155/47/7/313.Peer-Reviewed Original ResearchConceptsTumor potential doubling timeContinuous low dose rate irradiationTumor cell survivalSeed implantsBio-mathematical modelCell survivalExternal beam radiotherapyPresence of edemaProstate seed implantationLow dose rate irradiationEdema magnitudeEffects of edemaPotential doubling timeTypical edemaDose rate irradiationProstate volumeSurgical traumaPermanent seed implantsSeed implantationSignificant edemaTreatment strategiesSurgical proceduresBeam radiotherapyEdemaDose coverage
1999
Optimum timing for image-based dose evaluation of 125I and 103Pd prostate seed implants
Yue N, Chen Z, Peschel R, Dicker A, Waterman F, Nath R. Optimum timing for image-based dose evaluation of 125I and 103Pd prostate seed implants. International Journal Of Radiation Oncology • Biology • Physics 1999, 45: 1063-1072. PMID: 10571216, DOI: 10.1016/s0360-3016(99)00282-5.Peer-Reviewed Original ResearchConceptsDose-volume histogramsProstate volumeDose coverageConventional dose-volume histogramsSeed implantsEdema magnitudeMagnitude of edemaOptimum timingPostimplant dose-volume histogramDose evaluationOptimal patient managementProstate seed implantationPreimplant planImplant patientsPermanent brachytherapy implantsProstate seed implantsPatient managementProstate cancerSeed implantationSurgical proceduresEdemaProstateDose distributionDays postimplantationPatients