2001
Preoperative Anxiolysis and Postoperative Recovery in Women Undergoing Abdominal Hysterectomy
Kain Z, Sevarino F, Rinder C, Pincus S, Alexander G, Ivy M, Heninger G. Preoperative Anxiolysis and Postoperative Recovery in Women Undergoing Abdominal Hysterectomy. Anesthesiology 2001, 94: 415-422. PMID: 11374599, DOI: 10.1097/00000542-200103000-00009.Peer-Reviewed Original ResearchConceptsMorning of surgeryAbdominal hysterectomyPostoperative painAnalgesia useTreatment groupsGroup differencesLate postoperative time pointsPatient-controlled analgesia consumptionSelf-reported postoperative painPatient-controlled analgesia usePostoperative clinical courseTime pointsPostoperative time pointsMillions of patientsMinimal beneficial effectsLittle objective dataAnalgesic consumptionRecovery parametersAnalgesia consumptionIntramuscular midazolamPostoperative outcomesPostoperative periodPostoperative recoveryAbdominal surgeryClinical course
2000
Preoperative anxiety and postoperative pain in women undergoing hysterectomy A repeated-measures design
Kain Z, Sevarino F, Alexander G, Pincus S, Mayes L. Preoperative anxiety and postoperative pain in women undergoing hysterectomy A repeated-measures design. Journal Of Psychosomatic Research 2000, 49: 417-422. PMID: 11182434, DOI: 10.1016/s0022-3999(00)00189-6.Peer-Reviewed Original ResearchConceptsPostoperative pain responsePreoperative state anxietyPostoperative painPreoperative anxietyPain responseElective abdominal hysterectomyImmediate postoperative painPostoperative pain managementState anxietyAnalgesic consumptionAbdominal hysterectomyPositive predictorPerioperative periodPain managementSurgical managementMultiple time pointsPainRepeated-measures designTime pointsStudy sampleHysterectomySignificant positive predictorPerceived stressWardsAnxiety
1999
Leptin and the Perioperative Neuroendocrinological Stress Response1
Kain Z, Zimolo Z, Heninger G. Leptin and the Perioperative Neuroendocrinological Stress Response1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 2438-2442. PMID: 10404818, DOI: 10.1210/jcem.84.7.5850.Peer-Reviewed Original ResearchConceptsSurgical stressLeptin decreaseHigh-dose opioid techniqueCortisol increasePhase IHigh-dose fentanylSurgical stress responseTotal abdominal hysterectomyCardiac surgery patientsBaseline 2 hPossible adverse outcomesBaseline 24 hPhase IIAcute stress responseDose fentanylAbdominal hysterectomyPostoperative morbiditySurgery patientsHysterectomy patientsLeptin levelsAnesthetic techniqueAdverse outcomesAdrenocortical axisCardiac patientsNeuroendocrine hormones