2001
Preoperative Anxiolysis and Postoperative Recovery in Women Undergoing Abdominal Hysterectomy
Kain Z, Sevarino F, Rinder C, Pincus S, Alexander G, Ivy M, Heninger G. Preoperative Anxiolysis and Postoperative Recovery in Women Undergoing Abdominal Hysterectomy. Anesthesiology 2001, 94: 415-422. PMID: 11374599, DOI: 10.1097/00000542-200103000-00009.Peer-Reviewed Original ResearchConceptsMorning of surgeryAbdominal hysterectomyPostoperative painAnalgesia useTreatment groupsGroup differencesLate postoperative time pointsPatient-controlled analgesia consumptionSelf-reported postoperative painPatient-controlled analgesia usePostoperative clinical courseTime pointsPostoperative time pointsMillions of patientsMinimal beneficial effectsLittle objective dataAnalgesic consumptionRecovery parametersAnalgesia consumptionIntramuscular midazolamPostoperative outcomesPostoperative periodPostoperative recoveryAbdominal surgeryClinical course
2000
Midazolam: Effects on Amnesia and Anxiety in Children
Kain Z, Hofstadter M, Mayes L, Krivutza D, Alexander G, Wang S, Reznick J. Midazolam: Effects on Amnesia and Anxiety in Children. Anesthesiology 2000, 93: 676. PMID: 10969300, DOI: 10.1097/00000542-200009000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAmnesiaAnti-Anxiety AgentsAnxietyChildChild, PreschoolDouble-Blind MethodFemaleHumansMaleMemoryMental RecallMidazolamTime FactorsConceptsOral midazolamMidazolam administrationAnterograde amnesiaGood anterograde amnesiaSignificant anterograde amnesiaInduction of anesthesiaSignificant anxiolytic effectMidazolam groupGeneral anesthesiaSignificant group differencesAnxiolytic effectsBusy operating roomSurgical proceduresPostintervention testingDrug AdministrationControl groupMidazolamBaseline testingAnxiety measurement toolAnxiety of childrenOperating roomAdministrationGroup differencesPicture cardsAnesthesiaAttenuation of the Preoperative Stress Response with Midazolam
Kain Z, Sevarino F, Pincus S, Alexander G, Wang S, Ayoub C, Kosarussavadi B. Attenuation of the Preoperative Stress Response with Midazolam. Anesthesiology 2000, 93: 141-147. PMID: 10861157, DOI: 10.1097/00000542-200007000-00024.Peer-Reviewed Original ResearchConceptsPlacebo groupTreatment groupsPostoperative anxietyPreoperative sedativesPreoperative stress responsePlacebo-controlled trialFirst postoperative weekGreater reductionGlobal health indexAnalgesic consumptionIbuprofen usePlacebo injectionsPostoperative painClinical recoveryIntramuscular midazolamSurgery lengthPain recoveryPostoperative weekAnesthetic techniqueGeneral anesthesiaOutpatient surgeryPreoperative outcomesClinical significanceMidazolamSurgery
1999
An alternative method to alleviate postoperative nausea and vomiting in children
Wang S, Hofstadter M, Kain Z. An alternative method to alleviate postoperative nausea and vomiting in children. Journal Of Clinical Anesthesia 1999, 11: 231-234. PMID: 10434220, DOI: 10.1016/s0952-8180(99)00035-5.Peer-Reviewed Original ResearchConceptsPostoperative nauseaGeneral anesthesiaTreatment groupsControl groupASA physical status IPediatric surgery centersPhysical status IElective outpatient surgeryVisual analog scaleChildren ages 6Intravenous ondansetronAntiemetic effectRescue therapyStatus IRecurrent nauseaAnalog scaleOutpatient surgerySurgery centersNauseaVomitingEffective treatmentTreatment sequenceAge 6SurgeryAnesthesiaPostoperative Behavioral Outcomes in Children
Kain Z, Mayes L, Wang S, Hofstadter M. Postoperative Behavioral Outcomes in Children. Anesthesiology 1999, 90: 758-765. PMID: 10078677, DOI: 10.1097/00000542-199903000-00018.Peer-Reviewed Original ResearchConceptsPostoperative behavioral outcomesPostoperative day 1Induction of anesthesiaNegative behavioral changesPlacebo groupDay 1Multivariate logistic regression modelRecent stressful life eventsBehavioral changesFirst postoperative weekPostoperative behavioral changesPaucity of dataLogistic regression modelsPost Hospitalization Behavior QuestionnaireBehavioral outcomesMidazolam groupStressful life eventsPostoperative weekBehavioral recoveryIntervention groupPreoperative anxietyWeek 2Lower anxiety levelsSedative premedicationMeasures of anxiety