2022
Rat Model of Late Gestational Alcohol Exposure Produces Similar Life-Long Changes in Thalamic Nucleus Reuniens Following Moderate- Versus High-Dose Insult
Gursky ZH, Klintsova AY. Rat Model of Late Gestational Alcohol Exposure Produces Similar Life-Long Changes in Thalamic Nucleus Reuniens Following Moderate- Versus High-Dose Insult. Alcohol And Alcoholism 2022, 57: 413-420. PMID: 35258554, PMCID: PMC9270984, DOI: 10.1093/alcalc/agac008.Peer-Reviewed Original ResearchConceptsBrain growth spurtBlood alcohol concentrationPeak blood alcohol concentrationAlcohol exposureThalamic nucleus reuniensRat modelNucleus reuniensSubstantial neuron lossBinge alcohol exposureFetal alcohol spectrum disordersGestational alcohol exposureNon-neuronal cellsLife-long changesAlcohol spectrum disordersNeuron lossIntragastric intubationRat pupsThalamic damageAE groupBehavioral alterationsCell lossLow dosesPrefrontal cortexUnbiased stereological estimationGrowth spurt
2021
Executive functioning-specific behavioral impairments in a rat model of human third trimester binge drinking implicate prefrontal-thalamo-hippocampal circuitry in Fetal Alcohol Spectrum Disorders
Gursky ZH, Savage LM, Klintsova AY. Executive functioning-specific behavioral impairments in a rat model of human third trimester binge drinking implicate prefrontal-thalamo-hippocampal circuitry in Fetal Alcohol Spectrum Disorders. Behavioural Brain Research 2021, 405: 113208. PMID: 33640395, PMCID: PMC8005484, DOI: 10.1016/j.bbr.2021.113208.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBehavior, AnimalBinge DrinkingCentral Nervous System DepressantsCognitive DysfunctionDisease Models, AnimalEthanolExecutive FunctionFemaleFetal Alcohol Spectrum DisordersHypothalamusMaleNerve NetPrefrontal CortexPregnancyPregnancy Trimester, ThirdRatsRats, Long-EvansThalamusConceptsExecutive functioningFetal alcohol spectrum disordersNovel object recognitionPrenatal alcohol exposureBehavioral impairmentsSpectrum disorderAlcohol spectrum disordersPrefrontal cortexObject recognitionBehavioral flexibility tasksSpontaneous alternationPlus-maze taskMedial prefrontal cortexAlcohol exposureThalamic nucleus reuniensAlcohol-exposed ratsLong-Evans rat pupsFlexibility taskReversal learningDiscrimination learningSham intubationsBehavioral alterationsDevelopmental alcoholAssociative memoryMaze task
2020
Postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat
Gursky ZH, Johansson JR, Klintsova AY. Postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat. International Journal Of Developmental Neuroscience 2020, 80: 558-571. PMID: 32681672, PMCID: PMC8246316, DOI: 10.1002/jdn.10051.Peer-Reviewed Original ResearchConceptsPostnatal alcohol exposureEarly postnatal alcohol exposureAlcohol exposureAdolescent exerciseCerebellar volumeMicroglial densityCerebellar microgliaRodent modelsAberrant cerebellar connectivityMicroglia-specific proteinsFetal alcohol spectrum disordersPotential therapeutic effectsDevelopmental alcohol exposurePostnatal day 42Female Long-EvansAlcohol spectrum disordersExercise interventionMicroglial dysfunctionNeuroimmune dysfunctionNeuroimmune cellsNeuroimmune functionVoluntary exerciseTherapeutic effectMicrogliaCerebellar connectivitySingle-day Postnatal Alcohol Exposure Induces Apoptotic Cell Death and Causes long-term Neuron Loss in Rodent Thalamic Nucleus Reuniens
Gursky ZH, Spillman EC, Klintsova AY. Single-day Postnatal Alcohol Exposure Induces Apoptotic Cell Death and Causes long-term Neuron Loss in Rodent Thalamic Nucleus Reuniens. Neuroscience 2020, 435: 124-134. PMID: 32251710, PMCID: PMC7236664, DOI: 10.1016/j.neuroscience.2020.03.046.Peer-Reviewed Original ResearchConceptsFetal alcohol spectrum disordersAlcohol exposureThalamic nucleus reuniensCell lossAlcohol administrationFemale Long-Evans rat pupsNucleus reuniensApoptotic cell deathNon-neuronal cell numbersThird trimester alcohol exposureLong-Evans rat pupsCell deathPostnatal alcohol exposureAlcohol-exposed animalsFunction of hippocampusDevelopmental alcohol exposurePostnatal day 7Evans rat pupsEarly life stressAlcohol spectrum disordersCell numberCell type-dependent mannerNeuron lossRat pupsRodent models
2019
Nucleus reuniens of the midline thalamus of a rat is specifically damaged after early postnatal alcohol exposure
Gursky ZH, Savage LM, Klintsova AY. Nucleus reuniens of the midline thalamus of a rat is specifically damaged after early postnatal alcohol exposure. Neuroreport 2019, 30: 748-752. PMID: 31095109, PMCID: PMC6599629, DOI: 10.1097/wnr.0000000000001270.Peer-Reviewed Original ResearchConceptsNon-neuronal cell numbersFetal alcohol spectrum disordersPostnatal day 4Alcohol spectrum disordersNeuroanatomical alterationsAlcohol exposureMidline thalamusFemale Long-Evans rat pupsNucleus reuniensDay 4Early postnatal alcohol exposureLong-Evans rat pupsNeuron numberCircuit-level alterationsPostnatal alcohol exposureTotal neuron numberMidline thalamic nucleiEthanol-induced changesCell numberThalamic nucleus reuniensAdministration of liquidsVentral midline thalamusThalamic nucleiNeuronal markersRat pups
2017
Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD.
Gursky ZH, Klintsova AY. Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD. Journal Of Visualized Experiments 2017 PMID: 28190057, PMCID: PMC5407705, DOI: 10.3791/54947.Peer-Reviewed Original ResearchConceptsAnimal modelsTherapeutic interventionsAge-related neurodegenerationAdult hippocampusNeurotrophic factorAdult neurogenesisAerobic exercisePrenatal exposureRodent modelsPowerful therapeutic interventionNeuroplastic potentialNeurological disordersSubcortical structuresNeuroanatomical aspectsWheel runningInterventionRodentsHippocampusRatsNeurogenesisNew cellsNeurodegenerationBrain