2021
Executive functioning-specific behavioral impairments in a rat model of human third trimester binge drinking implicate prefrontal-thalamo-hippocampal circuitry in Fetal Alcohol Spectrum Disorders
Gursky ZH, Savage LM, Klintsova AY. Executive functioning-specific behavioral impairments in a rat model of human third trimester binge drinking implicate prefrontal-thalamo-hippocampal circuitry in Fetal Alcohol Spectrum Disorders. Behavioural Brain Research 2021, 405: 113208. PMID: 33640395, PMCID: PMC8005484, DOI: 10.1016/j.bbr.2021.113208.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBehavior, AnimalBinge DrinkingCentral Nervous System DepressantsCognitive DysfunctionDisease Models, AnimalEthanolExecutive FunctionFemaleFetal Alcohol Spectrum DisordersHypothalamusMaleNerve NetPrefrontal CortexPregnancyPregnancy Trimester, ThirdRatsRats, Long-EvansThalamusConceptsExecutive functioningFetal alcohol spectrum disordersNovel object recognitionPrenatal alcohol exposureBehavioral impairmentsSpectrum disorderAlcohol spectrum disordersPrefrontal cortexObject recognitionBehavioral flexibility tasksSpontaneous alternationPlus-maze taskMedial prefrontal cortexAlcohol exposureThalamic nucleus reuniensAlcohol-exposed ratsLong-Evans rat pupsFlexibility taskReversal learningDiscrimination learningSham intubationsBehavioral alterationsDevelopmental alcoholAssociative memoryMaze task
2020
Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function
Savage LM, Nunes PT, Gursky ZH, Milbocker KA, Klintsova AY. Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function. Neuropsychology Review 2020, 31: 447-471. PMID: 32789537, PMCID: PMC7878584, DOI: 10.1007/s11065-020-09450-8.Peer-Reviewed Original ResearchConceptsAlcohol-related brain damageBrain damageAlcohol use disorderMidline thalamusAlcohol-related cognitive dysfunctionCognitive dysfunctionDistinct thalamocortical pathwaysAlcohol-related damageLoss of neuronsThalamo-cortical circuitsDevelopmental ethanol exposureBehavioral outcomesCognition functionCentral brain structuresBehavioral interventionsLimbic nucleiThalamic pathologyThalamocortical pathwaysEthanol exposureThalamic damageUse disordersAnimal modelsThalamusBrain structuresFlexible adaptation
2019
Nucleus reuniens of the midline thalamus of a rat is specifically damaged after early postnatal alcohol exposure
Gursky ZH, Savage LM, Klintsova AY. Nucleus reuniens of the midline thalamus of a rat is specifically damaged after early postnatal alcohol exposure. Neuroreport 2019, 30: 748-752. PMID: 31095109, PMCID: PMC6599629, DOI: 10.1097/wnr.0000000000001270.Peer-Reviewed Original ResearchConceptsNon-neuronal cell numbersFetal alcohol spectrum disordersPostnatal day 4Alcohol spectrum disordersNeuroanatomical alterationsAlcohol exposureMidline thalamusFemale Long-Evans rat pupsNucleus reuniensDay 4Early postnatal alcohol exposureLong-Evans rat pupsNeuron numberCircuit-level alterationsPostnatal alcohol exposureTotal neuron numberMidline thalamic nucleiEthanol-induced changesCell numberThalamic nucleus reuniensAdministration of liquidsVentral midline thalamusThalamic nucleiNeuronal markersRat pups