2022
Representation of prefrontal axonal efferents in the thalamic nucleus reuniens in a rodent model of fetal alcohol exposure during third trimester
Smith IF, Gursky ZH, Klintsova AY. Representation of prefrontal axonal efferents in the thalamic nucleus reuniens in a rodent model of fetal alcohol exposure during third trimester. Frontiers In Behavioral Neuroscience 2022, 16: 993601. PMID: 36160686, PMCID: PMC9493097, DOI: 10.3389/fnbeh.2022.993601.Peer-Reviewed Original ResearchMedial prefrontal cortexFetal alcohol spectrum disordersAlcohol exposureThalamic nucleus reuniensRodent modelsNucleus reuniensBinge alcohol exposureThird-trimester exposureFetal alcohol exposurePostnatal day 4Alcohol spectrum disordersLong-Evans ratsExecutive functioningAE animalsTrimester exposureThird trimesterDisynaptic pathwayMPFC neuronsAxons synapseFemale ratsMale ratsAxon terminalsAxonal projectionsControl animalsHippocampal cellsRat Model of Late Gestational Alcohol Exposure Produces Similar Life-Long Changes in Thalamic Nucleus Reuniens Following Moderate- Versus High-Dose Insult
Gursky ZH, Klintsova AY. Rat Model of Late Gestational Alcohol Exposure Produces Similar Life-Long Changes in Thalamic Nucleus Reuniens Following Moderate- Versus High-Dose Insult. Alcohol And Alcoholism 2022, 57: 413-420. PMID: 35258554, PMCID: PMC9270984, DOI: 10.1093/alcalc/agac008.Peer-Reviewed Original ResearchConceptsBrain growth spurtBlood alcohol concentrationPeak blood alcohol concentrationAlcohol exposureThalamic nucleus reuniensRat modelNucleus reuniensSubstantial neuron lossBinge alcohol exposureFetal alcohol spectrum disordersGestational alcohol exposureNon-neuronal cellsLife-long changesAlcohol spectrum disordersNeuron lossIntragastric intubationRat pupsThalamic damageAE groupBehavioral alterationsCell lossLow dosesPrefrontal cortexUnbiased stereological estimationGrowth spurt
2021
Changes in Representation of Thalamic Projection Neurons within Prefrontal-Thalamic-Hippocampal Circuitry in a Rat Model of Third Trimester Binge Drinking
Gursky ZH, Klintsova AY. Changes in Representation of Thalamic Projection Neurons within Prefrontal-Thalamic-Hippocampal Circuitry in a Rat Model of Third Trimester Binge Drinking. Brain Sciences 2021, 11: 323. PMID: 33806485, PMCID: PMC8001051, DOI: 10.3390/brainsci11030323.Peer-Reviewed Original ResearchFetal alcohol spectrum disordersAlcohol exposureMedial prefrontal cortexVentral hippocampusProjection neuronsShort-term alcohol exposureLong-Evans rat pupsPrefrontal cortexBrain growth spurtThalamic projection neuronsDevelopmental alcohol exposureAlcohol spectrum disordersThalamic nucleus reuniensExecutive functioningRE neuronsNeuron lossThird trimesterThalamic connectivityRat modelRat pupsHippocampal circuitryRodent modelsBinge drinkingNucleus reuniensNeuron number
2020
Single-day Postnatal Alcohol Exposure Induces Apoptotic Cell Death and Causes long-term Neuron Loss in Rodent Thalamic Nucleus Reuniens
Gursky ZH, Spillman EC, Klintsova AY. Single-day Postnatal Alcohol Exposure Induces Apoptotic Cell Death and Causes long-term Neuron Loss in Rodent Thalamic Nucleus Reuniens. Neuroscience 2020, 435: 124-134. PMID: 32251710, PMCID: PMC7236664, DOI: 10.1016/j.neuroscience.2020.03.046.Peer-Reviewed Original ResearchConceptsFetal alcohol spectrum disordersAlcohol exposureThalamic nucleus reuniensCell lossAlcohol administrationFemale Long-Evans rat pupsNucleus reuniensApoptotic cell deathNon-neuronal cell numbersThird trimester alcohol exposureLong-Evans rat pupsCell deathPostnatal alcohol exposureAlcohol-exposed animalsFunction of hippocampusDevelopmental alcohol exposurePostnatal day 7Evans rat pupsEarly life stressAlcohol spectrum disordersCell numberCell type-dependent mannerNeuron lossRat pupsRodent models
2019
Nucleus reuniens of the midline thalamus of a rat is specifically damaged after early postnatal alcohol exposure
Gursky ZH, Savage LM, Klintsova AY. Nucleus reuniens of the midline thalamus of a rat is specifically damaged after early postnatal alcohol exposure. Neuroreport 2019, 30: 748-752. PMID: 31095109, PMCID: PMC6599629, DOI: 10.1097/wnr.0000000000001270.Peer-Reviewed Original ResearchConceptsNon-neuronal cell numbersFetal alcohol spectrum disordersPostnatal day 4Alcohol spectrum disordersNeuroanatomical alterationsAlcohol exposureMidline thalamusFemale Long-Evans rat pupsNucleus reuniensDay 4Early postnatal alcohol exposureLong-Evans rat pupsNeuron numberCircuit-level alterationsPostnatal alcohol exposureTotal neuron numberMidline thalamic nucleiEthanol-induced changesCell numberThalamic nucleus reuniensAdministration of liquidsVentral midline thalamusThalamic nucleiNeuronal markersRat pups