2023
Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRats
2022
Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus
Xue Y, Gursky Z, Monte B, Koundal S, Liu X, Lee H, Michurina TV, Mellanson KA, Zhao L, Nemajerova A, Kahle KT, Takemaru KI, Enikolopov G, Peunova NI, Benveniste H. Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus. Fluids And Barriers Of The CNS 2022, 19: 20. PMID: 35248089, PMCID: PMC8898469, DOI: 10.1186/s12987-022-00319-x.Peer-Reviewed Original ResearchConceptsGlymphatic transportIntracranial pressureMagnetic resonance imagingNasal cavityCribriform plateMouse modelFluid homeostasisOlfactory bulb hypoplasiaDistinct mouse modelsNormal intracranial pressureAquaporin-4 expressionKnock-out (KO) miceWild-type littermatesConditional knockout miceChronic rhinitisCommon findingSeparate cohortAQP4 expressionAQP4 polarizationKnockout miceHydrocephalusResonance imagingConclusionsThe combinationGadoteric acidBrain morphometry