Identification of multi-loci hubs from 4C-seq demonstrates the functional importance of simultaneous interactions
Jiang T, Raviram R, Snetkova V, Rocha PP, Proudhon C, Badri S, Bonneau R, Skok JA, Kluger Y. Identification of multi-loci hubs from 4C-seq demonstrates the functional importance of simultaneous interactions. Nucleic Acids Research 2016, 44: 8714-8725. PMID: 27439714, PMCID: PMC5062970, DOI: 10.1093/nar/gkw568.Peer-Reviewed Original ResearchConceptsMulti-locus interactionsDNA FISHGene regulationChromosome conformation capture techniquesFunctional importancePairwise chromatin interactionsChromatin interactionsTranscriptional outputRegulatory elementsEnhancer elementsBiological settingsSame cellsSimultaneous interactionFishNew insightsEnhancerRegulationReceptor enhancerCapture techniquesInteractionTCRB