2004
Lineage specificity of gene expression patterns
Kluger Y, Tuck DP, Chang JT, Nakayama Y, Poddar R, Kohya N, Lian Z, Nasr A, Halaban HR, Krause DS, Zhang X, Newburger PE, Weissman SM. Lineage specificity of gene expression patterns. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 6508-6513. PMID: 15096607, PMCID: PMC404075, DOI: 10.1073/pnas.0401136101.Peer-Reviewed Original ResearchConceptsGene expression patternsExpression patternsExpression dataGene Ontology databaseTree of relationshipsStem cellsBroad functional categoriesHematopoietic cell populationsMRNA expression dataHematopoietic programBioCarta databasesGenome databaseLineage choiceHematopoietic stem cellsKyoto EncyclopediaDifferent lineagesFunctional categoriesLineage developmentCell lineagesGene expressionLineage specificityOligonucleotide microarraysFunctional pathwaysLineage discriminationOntology database
2001
Genomic and proteomic analysis of the myeloid differentiation program
Lian Z, Wang L, Yamaga S, Bonds W, Beazer-Barclay Y, Kluger Y, Gerstein M, Newburger P, Berliner N, Weissman S. Genomic and proteomic analysis of the myeloid differentiation program. Blood 2001, 98: 513-524. PMID: 11468144, DOI: 10.1182/blood.v98.3.513.Peer-Reviewed Original ResearchConceptsNew transcription factorMammalian cell typesMurine bone marrow cellsGene expression patternsDominant-negative retinoic acid receptorGene expression changesTranscription regulatory factorsMyeloid differentiation programRetinoic acid receptorsTranscription factorsProteomic analysisDifferentiation programArray hybridizationDifferential displayExpression patternsExpression changesPromyelocytic cell lineRegulatory factorsMyeloid differentiationLevels of mRNACell typesMolecular levelExtensive catalogueMicroM retinoic acidBone marrow cells