Yu Sun
Associate Research Scientist in NeuroscienceCards
About
Research
Publications
2026
Recent Progress in Mechanism-Based Therapies for GJB2-Related Hearing Loss
Liu C, Wang X, Sun Y. Recent Progress in Mechanism-Based Therapies for GJB2-Related Hearing Loss. International Journal Of Molecular Sciences 2026, 27: 4313. PMID: 42196291, PMCID: PMC13206868, DOI: 10.3390/ijms27104313.Peer-Reviewed Original ResearchConceptsHearing lossGJB2-related hearing lossTherapeutic strategiesPharmacological modulationPathogenic mechanismsMechanism-based therapiesCochlear microenvironmentCochlear injuryChannel dysfunctionClinical presentationGene therapyClinical phenotypeEpithelial degenerationTherapeutic approachesMultiple pathological processesDevelopmental abnormalitiesDevelopmental windowJunction defectsHearingDamage pathwaysTherapyPathological processesBiological basisMechanism-basedTranscriptional regulationThe Impact of the “Healthy China 2030” planning outline strategy on the development of China’s medical and health resources—based on interrupted time series analysis from 1990 to 2023
Aximu N, Yimingniyazi B, Lin D, Wang X, Li M, Gao H, Zhang J, Han D, Sun Y. The Impact of the “Healthy China 2030” planning outline strategy on the development of China’s medical and health resources—based on interrupted time series analysis from 1990 to 2023. Scientific Reports 2026 PMID: 42045387, DOI: 10.1038/s41598-026-49076-z.Peer-Reviewed Original ResearchTotal health expenditureInterrupted time series analysisHealth resourcesInterrupted time seriesGovernment health expenditureHealth expenditureHealthy ChinaRegistered NursesHealth investmentHealth personnelHuman resource indicatorsHospital bedsChina Health Statistical YearbookHealth workforce trainingNational health strategyHealth technical personnelHealth Statistics YearbookQuasi-experimental analysisIntervention start pointsPer capita health expenditureSegmented regression analysisNational-level dataHealth strategiesIndicators of financial resourcesHealth techniciansGenetic Architecture and Molecular Mechanisms of Fusarium Crown Rot Resistance in Wheat
Shi X, Zhao S, Chen Y, Liu Y, Liu H, Sun Y, Li J, Shang J. Genetic Architecture and Molecular Mechanisms of Fusarium Crown Rot Resistance in Wheat. Plant Cell & Environment 2026 PMID: 42020957, DOI: 10.1111/pce.70553.Peer-Reviewed Original ResearchFusarium crown rot resistanceFusarium crown rotSoil-borne diseasesSoil-borne disease of wheatCrown rot resistanceDisease of wheatReactive oxygen species homeostasisMolecular mechanismsCell wall integrityWheat cultivarsCrown rotRot resistanceMulti-omics approachResistance breedingGenetic improvementWild relativesFeed safetyFusarium pseudograminearumFusarium culmorumResistance lociPrecision phenotypingFusarium graminearumPhytohormone pathwaysWheatGenetic architectureSARS-CoV-2 directly infects the inner ear and causes hearing dysfunction
Liu X, Zong Y, Liu K, Shi X, Zhao Z, Shan C, Sun Y. SARS-CoV-2 directly infects the inner ear and causes hearing dysfunction. Cell Reports 2026, 45: 117251. PMID: 41936052, DOI: 10.1016/j.celrep.2026.117251.Peer-Reviewed Original ResearchSpiral ganglion neuronsSARS-CoV-2 strainsIntranasal infectionStress granulesAberrant aggregationSARS-CoV-2Inner earIntracellular phase separationCell surface receptorsAuditory dysfunctionHearing lossMTOR Signaling PathwayHearing dysfunctionGanglion neuronsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Direct infectionTherapeutic strategiesHost cellsNeuronal cell apoptosisSyndrome coronavirus 2Signaling pathwayViral entryCell apoptosisMachine learning-enabled design of MOF-based membranes for efficient C3H8-selective separation
Zhang Z, Wang M, Tian W, Cao X, Zhao M, Sun Y, Qiao Z. Machine learning-enabled design of MOF-based membranes for efficient C3H8-selective separation. Journal Of Membrane Science 2026, 745: 125244. DOI: 10.1016/j.memsci.2026.125244.Peer-Reviewed Original ResearchMOF-based membranesHigh-throughput computational screeningCoRE-MOFsComposite membranesSeparation performanceEfficient C3H6/C3H8 separationConfigurational-bias Monte Carlo simulationsNext-generation membranesC3H6/C3H8 separationGas separationMachine learningIL@MOFMOFSeparationGeometric criteriaPerformance evaluationML modelsHigh performanceHierarchical strategyComputer screenMachinePerformanceA precision therapy paradigm for noise-induced hearing loss: integrating transcriptome-guided drug repurposing with in situ hydrogel delivery
Cai Q, Shi M, Chen J, Kong C, Wang X, Yuan Y, Lu J, Zheng D, Sun Y. A precision therapy paradigm for noise-induced hearing loss: integrating transcriptome-guided drug repurposing with in situ hydrogel delivery. Biomaterials Science 2026, 14: 1723-1737. PMID: 41770092, DOI: 10.1039/d6bm00030d.Peer-Reviewed Original ResearchConceptsNoise-induced hearing lossAuditory brainstem responseHearing lossGBR 12935Dopamine transporterMouse modelSevere acoustic traumaCochlear ribbon synapsesClinical translationRound window nicheCochlear synaptopathyBrainstem responseRobust functional recoveryNoise injuryGlobal health burdenThreshold shiftDrug residence timeAcoustic traumaIntratympanic administrationWindow nicheHealth burdenQuantitative immunofluorescenceTherapy strategiesCNS effectsMiddle earDual-chemokine-armed oncolytic Senecavirus A co-recruits cDC1 and CXCR3+ T cells to convert ‘cold’ melanoma and drive durable regression
Li W, Sun J, Tian H, Tang X, Gao L, Liang S, Zhang Z, Sun Y, Ma J, Zhao X. Dual-chemokine-armed oncolytic Senecavirus A co-recruits cDC1 and CXCR3+ T cells to convert ‘cold’ melanoma and drive durable regression. Journal For ImmunoTherapy Of Cancer 2026, 14: e014258. PMID: 41916730, PMCID: PMC13052620, DOI: 10.1136/jitc-2025-014258.Peer-Reviewed Original ResearchConceptsT cell infiltrationT cellsIntratumoral deliveryTherapeutic efficacyCD8+ T cell infiltrationCross-presenting dendritic cellsEngineered oncolytic virusesImmune-cold tumorsTumor immune landscapeDendritic cell activationImmune cell infiltrationB16-F10 melanoma cellsM1-polarized phenotypeTumor rechallengeTransgene capacityTumor controlTumor lysisImmunosuppressive microenvironmentTumor burdenTumor regressionOncolytic virusesImmune landscapeMouse survivalOncolytic virotherapyProlonged survivalA global-scale framework for quantifying the gut microbiomeʼs mediating role in environmental and personal determinants of health
Yuan Y, Ou J, Fu X, Tang Y, Chen Y, Deng Q, Deng Y, Sun Y. A global-scale framework for quantifying the gut microbiomeʼs mediating role in environmental and personal determinants of health. Eco-Environment & Health 2026, 5: 100236. PMID: 42004001, PMCID: PMC13087684, DOI: 10.1016/j.eehl.2026.100236.Peer-Reviewed Original ResearchPersistent organic pollutantsExposure to persistent organic pollutantsAlpha diversityExposure to pollutantsGlobal-scale analysisProtective effect of vegetable consumptionGlobal burdenEffect of vegetable consumptionSelf-reported health outcomesGut microbiomeOrganic pollutantsDeterminants of healthBurden of environmental diseasesMicrobial indicesHigh diversityHealth risksGut diversityMediation analysisIrritable bowel syndromeEnvironmental characteristicsVegetable consumptionPersonal determinantsHealth outcomesHuman gut microbiomePollutionLong-Term PM2.5 Constituents Exposure, Genetic Susceptibility, and Incident Sleep Apnea: A Prospective Cohort Study
Yin G, Cui F, Chen N, Xing M, Zheng L, Tang L, Yuan L, Tian Y, Zhu Y, Sun Y. Long-Term PM2.5 Constituents Exposure, Genetic Susceptibility, and Incident Sleep Apnea: A Prospective Cohort Study. Chest 2026 PMID: 41833808, DOI: 10.1016/j.chest.2026.02.025.Peer-Reviewed Original ResearchLong-term exposure to PMPMExposure to PMInterquartile range increaseEuropean MonitoringRange increaseEmission controlSleep apneaSA riskHazard ratioUK Biobank participantsWHO guidelinesModel meteorologyObese individualsProspective cohort studyGenome-wide significant SNPsTime-dependent Cox regressionBiobank participantsUK Biobank databaseStratified analysisUrban populationCohort studyEscherichia coli CueO Efficiently Detoxifies Aflatoxin B1 via a Mediator-Enhanced Two-Step Mechanism
Chen Q, Huang J, Song C, Chen T, Wu X, Sun Y, Mu P, Deng Y, Wang L. Escherichia coli CueO Efficiently Detoxifies Aflatoxin B1 via a Mediator-Enhanced Two-Step Mechanism. Journal Of Agricultural And Food Chemistry 2026, 74: 9749-9760. PMID: 41811361, DOI: 10.1021/acs.jafc.5c13936.Peer-Reviewed Original Research
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