Kill HIV by Starvation–Mechanism of Allosteric Activation of SAMHD1
Ji X, Wu Y, Yan J, Mehrens J, DeLucia M, Hao C, Gronenborn A, Skowronski J, Anh J, Xiong Y. Kill HIV by Starvation–Mechanism of Allosteric Activation of SAMHD1. Acta Crystallographica Section A: Foundations And Advances 2014, 70: c121-c121. DOI: 10.1107/s2053273314098787.Peer-Reviewed Original ResearchCellular dNTP poolsCellular dNTP levelsDNTP poolsDNTP levelsDeoxyribonucleoside triphosphate triphosphohydrolaseActive tetrameric formMammalian cellsAllosteric activationSAMHD1 functionAllosteric mechanismMajor regulatorAllosteric siteInactive dimerAllosteric bindingTetrameric formAicardi-Goutières syndromeTetrameric complexMechanistic understandingCongenital viral infectionViral reverse transcriptionMonomers/dimersSAMHD1Reverse transcriptionHIV restrictionClinical manifestations